A5030988903- Pneumonia and Respiratory Infections
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Traffic and Road Safety
- Transportation Safety and Impact Analysis
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Pneumocystis jirovecii pneumonia detection and treatment
- Vitamin C and Antioxidants Research
- Automotive and Human Injury Biomechanics
- Tuberculosis Research and Epidemiology
- Asthma and respiratory diseases
- Blood disorders and treatments
- Respiratory viral infections research
- Nitric Oxide and Endothelin Effects
- Antibiotic Resistance in Bacteria
- S100 Proteins and Annexins
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Antioxidant Activity and Oxidative Stress
- Rheumatoid Arthritis Research and Therapies
- Occupational Health and Safety Research
- Transportation Systems and Infrastructure
- Immunotherapy and Immune Responses
- Cardiovascular Function and Risk Factors
University of Pretoria
2016-2025
The Medical Oncology Centre of Rosebank
2024
Tshwane University of Technology
2007-2024
Brooke Army Medical Center
2023
University College London
2003-2021
The George Institute for Global Health
2020-2021
University of the Witwatersrand
1977-2020
Université de Nîmes
2020
Université de Montpellier
2020
Royal Brisbane and Women's Hospital
2020
Endothelins are peptides, originally isolated from endothelial cells, with potent vasoactive and mitogenic properties. In this study, we demonstrate that human macrophages synthesize secrete endothelins. Cultured were found by immunocytochemistry to stain positively for endothelin 1 3. Their capability produce release these peptides was confirmed a combination of reverse-phase high-performance liquid chromatography radioimmunoassays, specific 3, respectively. Immunoreactive identified both...
All mammalian hepadnaviruses possess a gene, termed X, that encodes protein capable of transactivating virus gene expression. The X overlaps the polymerase and precore genes as well two newly identified open reading frames (ORFs) ORF5 ORF6. In this investigation, we examined whether ORF5, ORF6, were important for replication woodchuck hepatitis (WHV) in susceptible woodchucks. First, investigated proteins produced from ORF6 by vitro translation appropriate viral transcripts, searched...
Abstract CD8+ T lymphocytes (TCD8+) play an important role in cellular immune responses. TCD8+ recognize MHC class I molecules complexed to peptides of 8 10 residues derived largely from cytosolic proteins. Proteins are generally thought be fragmented the cytoplasm and delivered nascent endoplasmic reticulum (ER) by a peptide transporter encoded MHC. To explore extent which induction vivo is limited proteolysis or transport into ER, mice were immunized with recombinant vaccinia viruses...
The accuracy of coronal and sagittal magnetic resonance (MR) imaging was examined in the assessment rotational sideways displacements temporomandibular joint (TMJ) disk. Rotational disk displacement implies a combination anterior medial or lateral displacements, whereas pure without an component. Multiple 3-mm-thick MR images were obtained 18 fresh TMJ autopsy specimens compared with observations corresponding cryosections. correctly delineated mediolateral position 15 joints (83%)...
Cryothermia, a new technique for definitive treatment of the pre-excitation syndrome, is described in two patients. The first patient presented with normal P-R interval delta wave and reciprocating tachycardia. Preoperative electrophysiologic study suggested free-wall atrioventricular connection on left posterior (A-V) groove. At surgery, epicardial mapping confirmed site ventricular (LV) wall. An electrogram arising from accessory pathway (AP) was recorded at earliest activation....
A 37-year-old man with a benign variant of scleroderma (CRST syndrome: calcinosis circumscripta, Raynaud's phenomenon, sclerodactyly, and telangiectasia) presented recurrent ventricular tachycardia. Preoperative electrophysiologic study suggested that the mechanism tachycardia was an ectopic pacemaker focus in right ventricle. Right dilatation, tricuspid insufficiency, normal pulmonary pressures, coronary arteries were also demonstrated. At surgery, epicardial mapping localized site origin...
We report brachial plexus biopsy findings from two Australian and American patients with neuropathy. There were florid multifocal mononuclear inflammatory cell infiltrates. Present evidence suggests that these neuropathies have an immune basis.
Under most circumstances, cell surface MHC class I molecules display peptides derived from a cytosolic pool of proteins. The efficient presentation such requires the functioning two gene products [TAP1 and TAP2 (transporter-associated with Ag processing 1 2)] that form complex facilitates transmembrane movement cytosol to endoplasmic reticulum, site peptide association molecules. It has been previously shown can be presented in TAP-independent manner HLA A2.1 or H-2 Kd if they are expressed...