A cohort of 1472 patients who underwent both exercise stress testing and coronary angiography within six weeks was examined. The data indicated that a combination parameters is diagnostically prognostically important. Almost all (greater than 97%) had positive tests at Stage I or II significant artery disease. More half these 60%) three vessel disease over 25% narrowing 50%) the left main artery. Patients achieved IV greater durations with either negative indeterminate ST-segment response...

Physiological studies of the type we have described, when performed in patients with WPW syndrome, can yield diagnostic information regarding mechanism arrhythmia, demonstrate functional properties therapeutic import, facilitate decision-making about drug regimens and presumptively localize site pre-excitation as a basis for possible surgical intervention. Based on our experience, feel that selected patients, correction syndrome is entirely feasible, be accomplished majority whom free wall...

Recurrent supraventricular tachycardia is a frequent complication in patients with the Wolff-Parkinson-White (WPW) syndrome. Our patient was unusual that arrhythmia predominant rhythm, and it felt sustained responsible for signs symptoms of congestive heart failure. The could not be controlled adequately digitalis, quinidine, diphenylhydantoin, or propranolol. Atrial ventricular pacing also failed to prevent recurrent episodes tachycardia. Physiological pharmacological studies suggested an...

The maximal rate of left ventricular pressure development (max. dp/dt) was measured in an areflexic preparation which permitted independent control stroke volume, heart rate, and aortic pressure. Max. dp/dt increased as a result elevating end-diastolic Elevating mean increasing each resulted higher max. without change Aortic diastolic shown to influence the absence changes or contractility. Increasing contractility while changing manner activation decreased dp/dt. These findings demonstrate...

Previous research has documented high rates of noncompliance to prescribed medical therapy in patients recovering from myocardial infarction (MI). This study was undertaken determine if who subsequently drop out a structured cardiac rehabilitation program could be prospectively distinguished those remain the based upon their initial baseline characteristics. Thirty-five consecutive with recent MIs underwent comprehensive physical and psychological assessments at entry into program, were...

Serial plasma determinations of the isoenzymes CPK were performed in all patients (376) admitted to a coronary care unit during 12-month period with diagnosis possible acute myocardial infarction. Results compared data from other enzyme studies and electrocardiogram. An attempt was made determine incidence falsely positive CPK-MB (myocardial-specific form). "No infarction" diagnosed whom neither total nor LDH indicated necrosis, there no QRS changes on ECG. Incidence negative isoenzyme also...

This report describes a 45-year-old man who developed acute bacterial endocarditis involving the aortic valve due to Klebsiella type 19. Consequent infection patient insufficiency and congestive heart failure. The failed respond adequately antibiotic therapy alone rapid clinical deterioration required that be replaced despite presence of active infection. Excision appears have removed site replacement with Starr prosthesis has corrected insufficiency. been followed for 15 months since...

The effects of altering stroke volume, aortic pressure and heart rate on the duration each phase left ventricular systole were investigated in a denervated dog heart. Augmenting volume was found to prolong ejection, shorten isovolumic period had little or no effect total systole. Elevating mean blood shortened ejection time, prolonged either decreased slightly Increasing at constant reduced all phases Digitalis norepinephrine These findings demonstrate that is dependent upon existing...

A cryosurgical instrument was used to ablate atrioventricular conduction. The procedure carried out in 20 dogs and subsequently three patients with drug resistant, life-threatening supraventricular tachycardias. In patients, the unit lowered temperature of His bundle area 0 degrees C, effecting complete but reversible heart block. Rewarming resulted resumption normal region then cooled -60 C; block produced two or more 90-120 second freezes. Postoperative evaluations revealed persistent...

Cryothermia, a new technique for definitive treatment of the pre-excitation syndrome, is described in two patients. The first patient presented with normal P-R interval delta wave and reciprocating tachycardia. Preoperative electrophysiologic study suggested free-wall atrioventricular connection on left posterior (A-V) groove. At surgery, epicardial mapping confirmed site ventricular (LV) wall. An electrogram arising from accessory pathway (AP) was recorded at earliest activation....

We have studied 135 patients with the pre-excitation syndrome and demonstrated evidence of multiple accessory pathways in 20 patients. Five had two distinct atrioventricular (A-V) connections, associated enhanced A-V node conduction one patient. Twelve a single connection conduction. In these there was an additional fasciculo-ventricular connection. One patient nodoventricular bundle. Two connections combined The latter electrocardiograms suggestive complete Patients shorter cycle lengths...

The use of heart block dog preparations allowed an investigation at constant ventricular rates the hemodynamic effects which resulted when timing atrial systole was altered relative to systole. Ganglionic blockade and vagotomy precluded sympathetic reflex compensation in these animals. Lengthening or shortening interval between left (As-Vs interval) produced a decrease end-diastolic pressure (LVEDP), mean aortic pressure, flow. Mean (MLAP) increased as did relation MLAP LVEDP. absence...

An attempt was made to assess the effects of aerobic exercise on psychological functioning a nonclinical sample healthy middle-aged adults. Sixteen subjects participated in 10-week program regular walking-jogging, while matched control group maintained their sedentary life-styles. All completed battery tests, including Profile Mood States, State-Trait Anxiety Inventory and retrospective questionnaire regarding self-perceptions change. Examination test scores revealed that for almost always...

The effects of a 10-week physical-conditioning program on fibrinolytic activity at rest and after stimulation by venous occlusion were studied in 69 healthy adults 25 to years old. Physical conditioning was documented treadmill performance, fibrinolysis measured with newly developed radioenzymatic assay. Whereas declined from 16.2 +/- 1.3 11.4 0.8 units (mean S.E.M.) (P = 0.0017), the increment produced increased 21.7 2.9 33.8 4.7 0.0037). This augmentation most marked women, persons low...

A 37-year-old man with a benign variant of scleroderma (CRST syndrome: calcinosis circumscripta, Raynaud's phenomenon, sclerodactyly, and telangiectasia) presented recurrent ventricular tachycardia. Preoperative electrophysiologic study suggested that the mechanism tachycardia was an ectopic pacemaker focus in right ventricle. Right dilatation, tricuspid insufficiency, normal pulmonary pressures, coronary arteries were also demonstrated. At surgery, epicardial mapping localized site origin...

The hemodynamic responses to CNS ischemia and perfusing the with hypoxic or hypercapnic blood were observed in dog. A dual, rotating disc oxygenator system was employed separately perfuse brachiocephalic artery distribution following confirmed bilateral carotid sinus area denervation. Cerebral produced a marked increase of pressure, peripheral vascular resistance, heart rate, atrial ventricular contractility. These same also by lowering pO 2 raising pCO perfusate, but somewhat less marked....

The effects of heart rate on left-ventricular performance were studied in an areflexic dog right-heart bypass preparation which allowed independent control aortic pressure, cardiac output, and rate. When the was increased while stroke volume mean pressure maintained constant rise during isovolumic systole, maximal ejection all without any change end-diastolic pressure. Further, it shown that left ventricle performed same amount work over a wide range rates increase spite markedly shortened...

Ventricular fibrillation was induced in eight of 10 open-chest dogs by reperfusion after a 15-minute occlusion the proximal circumflex coronary artery. Simultaneous recordings were made from 27 epicardial electrodes spaced over both ventricles. Analysis initial 1.5--2.5 seconds transition sinus rhythm or ventricular tachycardia to revealed that activation occurred an orderly, rapidly repeating sequence all hearts. Each arose near border ischemic-reperfused region and passed across...