A5101426349- Natural product bioactivities and synthesis
- Phytochemistry Medicinal Plant Applications
- Retinoids in leukemia and cellular processes
- Psidium guajava Extracts and Applications
- Ocular Diseases and Behçet’s Syndrome
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Water Quality and Pollution Assessment
- Sesquiterpenes and Asteraceae Studies
- Click Chemistry and Applications
- Fungal Biology and Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis and Reactivity of Heterocycles
- Tannin, Tannase and Anticancer Activities
- Retinal Diseases and Treatments
- Healthcare Regulation
- Antioxidant Activity and Oxidative Stress
- Parasitic Infections and Diagnostics
- Plant-Derived Bioactive Compounds
- Retinal and Optic Conditions
- Phytochemicals and Antioxidant Activities
- Public Health in Brazil
- Phytochemical compounds biological activities
- Botany, Ecology, and Taxonomy Studies
- Chemical synthesis and alkaloids
Universidade Federal de Minas Gerais
2015-2024
Centro de Espectrometria de Massas Aplicada (Brazil)
2015
The genus Jacaranda Juss. (Bignoniaceae) is native to Central and South America are known have antioxidant, antimicrobial anticancer activities. This study aimed identify phenolic flavonoid compounds from leaves twigs of three species the using HPLC-DAD-MS, ESI-MS Tandem MS (ESI-MS/MS), as well evaluate inhibitory activity extracts on enzyme acetylcholinesterase. Leaves caroba, mimosifolia oxyphylla were dried subjected extraction with hexane, chloroform methanol obtain crude extracts. In...
Seventeen borneol esters (1-17) were synthesised by conventional and microwave-assisted methodology using DIC/DMAP, seven are described for the first time (8, 9, 10, 12, 13, 16 17). The was carried out without use of solvents, displayed short reaction times, showed equal or higher yields all long-chain three aromatic compounds (11, 12 14) when compared to approach. All evaluated against bacteria Streptococcus sanguinis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa fungus...
Infections caused by microorganisms are a major cause of morbidity and mortality worldwide, natural products continue to be important sources for the discovery new antimicrobial agents. Ursolic acid is triterpene with known antibacterial action, being naturally found in plants, such as Jaracanda oxyphylla Jacaranda caroba (Bignoniaceae). derivative esters have revealed potential biological activities, antitumor, antiviral, activity. In this study, sixteen (1-16) were synthesized from ursolic...
V.V. Pereiraab*, C.R. Borelc & R.R. Silvada Departamento de Química, Universidade Federal Minas Gerais, Belo Horizonte, Brazilb Faculdade Farmácia, 31270-901 Brazilc Viçosa, 36570-900 Brazild dos Vales do Jequitinhonha e Mucuri, 39100-000 Diamantina, Brazil
Digital de Espécies Byrsonima Utilizando Espectrometria Massas com Ionização por EletrosprayResumo: Extratos plantas apresentam uma grande diversidade química e, geralmente
Jacaranda oxyphylla Cham. (Bignoniaceae) is a shrub found in the Brazilian cerrado and used folk medicine to treat microbial infections. The aim of this study was carry out phytochemical screening evaluate antioedematogenic, antimicrobial antiacetylcholinesterase properties J. crude extracts. All extracts analysed showed presence terpenoids, which are potentially active chemical substances. A high AChE inhibitory activity for hexane extract from leaves twigs found. Ethanol against...
Jacaranda oxyphylla Cham. is popularly known as 'caroba-de-São-Paulo' and it used in traditional medicine for microbial infections. A new phytoquinoid (α/β-glucoside-4-phenylacetate-6-(1-hydroxy-4-oxo-2,5-cyclohexadiene-1-acetate) (1) was isolated from J. leaves, together with three compounds: quercetin-3-O-β-d-galactoside (2), verbascoside (3) polystyrene (4). Their chemical structures were elucidated using spectroscopic techniques by comparison the related compounds. In addition, found a...
A água é um recurso natural com alto valor econômico agregado, que nem sempre próprio para o consumo humano. Na podem ser encontradas diversas substâncias químicas, como os íons ferro e manganês que, dependendo de sua concentração, causar danos à saúde humana. Assim, no presente estudo teve-se objetivo avaliar as concentrações em amostras bruta diferentes municípios do Estado Minas Gerais. Para isso, foram analisadas 422 provenientes 85 municípios, sendo originadas fontes, poços, cisternas,...
Lupeol is a pentacyclic triterpene with known anti-inflammatory effects. However, its role in the treatment of noninfectious uveitis has not been explored. This work investigated activity lupeol ocular tissues vitro and vivo models. First, we evaluated effect (100 µM) on inflammatory response induced by lipopolysaccharide (LPS) retinal pigment epithelium cells (ARPE-19) measuring levels released interleukins (IL-6 IL-8). Then, action intravitreal rodent model panuveitis Mycobacterium bovis...
Angiogenesis is the formation of new blood vessels from preexisting vasculature. Uncontrolled angiogenesis associated with progression several ocular pathologies, such as diabetic retinopathy and macular degeneration. Thus, inhibition this process consists in an interesting therapeutic target. Corosolic acid (CA) a natural derivative ursolic acid, found many medicinal herbs exhibits numerous biological properties, including antiangiogenic activity. The present study reports production...
Ursolic acid (UA) is an abundant natural product and has shown great promise for treating diseases related to the appearance of new blood vessels. However, its clinical use limited due low solubility in aqueous media, resulting reduced bioavailability. The present study aimed synthetize poly(lactic-co-glycolic acid) nanoparticles loaded with UA by nanoprecipitation method evaluate toxicity anti-angiogenic activity using
Extratos de plantas apresentam uma grande diversidade quimica e, geralmente, requerem um tempo excessivo para o isolamento e caracterizacao compostos. Analises amostras complexas utilizando fonte ionizacao por eletrospray acoplada a espectrometria massa (ESI-MS) tandem (ESI-MS/MS) tem-se mostrado uteis na triagem inicial dessas amostras. Assim, possivel fazer identificacao moleculas conhecidas sem previo ou outras tecnicas analiticas auxiliares. Neste trabalho, os extratos secos tres...
4-Aminopyrrolo[2,1-f][1,2,4]triazine is a fundamental raw material in the synthesis of remdesivir, which demand has increased due to tests and potential repositioning this drug against Coronavirus disease 2019 (COVID-19). Here, three chemical steps route for preparation remdesivir’s nucleobase described. Particularly, highly chemoselective cyanation Klein’s successful application monochloramine prepared from commercial bleach as an N-amination reagent are presented.
Esteres do borneol tem sido considerados como promissores agentes anti-inflamatorios e antimicrobianos. Neste trabalho, oito esteres ( 1-8 ) foram sintetizados utilizando o metodo DIC/DMAP ou SOCl 2 os produtos caracterizados por meio de tecnicas espectroscopicas. Seis desses compostos sao ineditos DIC/CMAP foi mais rapido resultou em rendimentos reacao elevados. Os submetidos ao ensaio antiproliferativo in vitro linhagens celulas normais tumorais a avaliacao da atividade antiedematogenica....
Este estudo objetivou analisar o conteudo parasitologico em seis reservatorios de agua usados para irrigacao alimentos no distrito Vale Verde, Minas Gerais, Brasil, buscando ovos dos parasitas intestinais Ascaris lumbricoides e Enterobius vermiculares, alem cistos Entamoeba histolytica Giardia lamblia. De 10 a 13 novembro 2015, amostras (n = 36) foram coletadas Verde analisadas microscopio optico quanto presenca alvos do estudo. Parasitas forma ou encontrados, especialmente E. histolytica,...