A5041762374- Natural Compounds in Disease Treatment
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Biological Activity of Diterpenoids and Biflavonoids
- Essential Oils and Antimicrobial Activity
- Phytochemical compounds biological activities
- Phytochemistry and Bioactivity Studies
- Mosquito-borne diseases and control
- Plant biochemistry and biosynthesis
- X-ray Diffraction in Crystallography
- Organic Chemistry Cycloaddition Reactions
- Phytochemistry Medicinal Plant Applications
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Crystallization and Solubility Studies
- Insect Pest Control Strategies
- Sesquiterpenes and Asteraceae Studies
- Viral Infections and Vectors
- Plant Diversity and Evolution
- Research on Leishmaniasis Studies
- Phytochemistry and Bioactive Compounds
- Natural Antidiabetic Agents Studies
- Pain Mechanisms and Treatments
- Synthesis and bioactivity of alkaloids
- Heavy Metals in Plants
Universidade Federal de Minas Gerais
2016-2025
Rede de Química e Tecnologia
2015
Universidade de Itaúna
2015
Centro Universitário de Belo Horizonte
2012
Leaves of Maytenus robusta (Celastraceae) were subjected to phytochemical investigation mainly directed at the isolation pentacyclic triterpenes. The compounds friedelin (1), β-friedelinol (2), 3-oxo-21β-H-hop-22(29)-ene (7), 3,4-seco-friedelan-3,11β-olide (8), 3β-hydroxy-21β-H-hop-22(29)-ene (9), 3,4-seco-21β-H-hop-22(29)-en-3-oic acid (10), 3,4-seco-friedelan-3-oic (11), and sitosterol identified in hexane extract M. leaves. Compounds 8 9 are described herein for first time. structure...
Background Tontelea micrantha, a notable plant species, has garnered interest for its medicinal properties, including anti-inflammatory, antibacterial and antiviral effects. A vaccine Chikungunia virus is still under evaluation no specific drug been licensed to date.
The triterpene lupeol (1) and some of its esters are secondary metabolites produced by species Celastraceae family, which have being associated with cytotoxic activity. We report herein the isolation 1, semi-synthesis eight evaluation their in vitro activity against nine strains cancer cells. reaction carboxylic acids 1 DIC/DMAP was used to obtain stearate (2), palmitate (3) miristate (4), new laurate (5), caprate (6), caprilate (7), caproate (8) 3',4'-dimethoxybenzoate (9), high yields....
Utilizando a técnica de hidrodestilação, usando um adaptador Clevenger, foram extraídos óleos essenciais das espécies Pimenta dioica (folhas e frutos) Syzygium aromaticum (botões florais, talos folhas). A composição química dos foi determinada através da analise CG-EM. Os teores variaram 0,97 1,41% 2,30 15,40% nas aromaticum, respectivamente. O componente majoritário presente nessas o eugenol, variando 72,87 90,41%. forneceu maior teor óleo essencial rico em eugenol. Em quantidades menores...
Mayaro virus (MAYV) is a sublethal arbovirus transmitted by mosquitoes with possible installation of an urban cycle in the Americas. Its infection causes disabling arthralgia, and still, there no vaccine or treatment to it. We recently investigated nearly 600 compounds molecular docking identified epicatechin as potent antiviral against MAYV. The root extract Maytenus imbricata showed anti-MAYV activity two isolated from this plant were also evaluated vitro. Proanthocyanidin (PAC), dimer...
An NMR study of 3α- and 3β-friedelinol is described. In addition to conventional 1D methods, 2D shift-correlated experiments HMQC [(1J(C,H)], HMBC [nJ(C,H); n=2 3] 1H,1H-NOESY were used for 1H 13C chemical shift assignments these triterpenes. Copyright © 2000 John Wiley & Sons, Ltd.
The phytochemical study of hexane, chloroform and methanol extracts from leaves Psychotria viridis resulted in the identification of: pentacyclic triterpenes, ursolic oleanolic acid; steroids, 24-methylene-cycloartanol, stigmasterol β-sitosterol; glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; esters glycerol, 1-palmitoylglycerol triacylglycerol; mixture long chain hydrocarbons; aldehyde nonacosanal; fat acids...
The phytochemical investigation on the aereal parts of Lychnophora pinaster Mart., Asteraceae, was carried to isolation triterpenes. 3-O-Acetyl-lupeol (1), 3-O-acetyl-pseudotaraxasterol (2), and 3-O-acetyl-α-amyrin (3) were isolated from hexanic extract 4,4-dimethyl-cholesta-22,24-dien-5-ol (4), α-amyrin (5), lupeol (6) hexanic/dichlorometanic leaves. Compounds Δ7-bauerenyl acetate (7), friedelin (8), stigmasterol (9), sitosterol (10) stems. steroids 9 10 also flowers. Triterpenes 1, 3, 4, 7...
A new series of glucosides modified in their saccharide units were synthesized, evaluated against Candida sp., and compared to prototype 1, an eugenol tetracetyl glucoside previously synthesized shown be active glabrata. Among the glucosides, benzyl derivative 5 was most promising, showing fungistatic activity at IC50 18.1 μm glabrata (threefold higher than fluconazole) fungicidal with a low IC90 value 36.2 μm. Moreover, cytotoxic compound (CC50 : 580.9 μm), tested peripheral blood...
Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue included among the neglected diseases in several underdeveloped developing countries, with urgent demand for new drugs. Considering antidiarrheal potential of species Maytenus genus, a phytochemical investigation followed antibacterial activity test extracts branches heartwood bark roots from gonoclada were conducted. Moreover, due frequency isolation lupeol genus antiviral against Dengue virus...
Substances derived from plants play an important role in the development of new analgesic drugs, among them, triterpenoids. The connection between participation L-arginine/NO/cGMP pathway and activation ATP-sensitive K(+) channels (KATP) has been established on peripheral antinociception induced by various drugs. study assessed involvement L-arginine/NO/cGMP/KATP antinociceptive effect tingenone, Maytenus imbricata, against hyperalgesia evoked prostaglandin E2 (PGE2) pathway. paw pressure...
The phytochemical study of hexane/ethyl ether (1:1) extract the roots M. imbricata, Celastraceae, resulted in isolation and characterization six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone 6-oxo-tingenol. chemical structures these triterpenes were established by spectrometric data (IR, ¹H 13C NMR) through comparison with literature data. (1:1),...
Seventeen borneol esters (1-17) were synthesised by conventional and microwave-assisted methodology using DIC/DMAP, seven are described for the first time (8, 9, 10, 12, 13, 16 17). The was carried out without use of solvents, displayed short reaction times, showed equal or higher yields all long-chain three aromatic compounds (11, 12 14) when compared to approach. All evaluated against bacteria Streptococcus sanguinis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa fungus...
Infections caused by microorganisms are a major cause of morbidity and mortality worldwide, natural products continue to be important sources for the discovery new antimicrobial agents. Ursolic acid is triterpene with known antibacterial action, being naturally found in plants, such as Jaracanda oxyphylla Jacaranda caroba (Bignoniaceae). derivative esters have revealed potential biological activities, antitumor, antiviral, activity. In this study, sixteen (1-16) were synthesized from ursolic...
Friedelin molecular conformers were obtained by Density Functional Theory (DFT) and ab initio structure determination from powder X-ray diffraction. Their with the five rings in chair-chair-chair-boat-boat, all chair, are energy degenerated gas-phase according to DFT results. The diffraction data reveals that A, B C of friedelin D E boat-boat, conformation. high correlation values among data, reported single-crystal indicate use conventional diffractometer can be applied routine laboratory...
Six pentacyclic triterpenes were isolated from hexane extract of stems Maytenus salicifolia Reissek, Celastraceae: 30-hydroxyfriedelan-3-one (1), 3,16-dioxofriedelane (2), friedeline (3), lupeol (4), betuline (5) and lup-20(29)-en-3,30-diol (6). The structure each one was established on the basis detailed ¹H 13C NMR spectral investigation by comparison with respective literature values. For compound 1, complete 2D (HMBC, HMQC NOESY) data herein reported for first time. Compounds 2, 5 6 time...