A5067491108- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Plant Pathogens and Fungal Diseases
- Essential Oils and Antimicrobial Activity
- Mosquito-borne diseases and control
- Microbial Natural Products and Biosynthesis
- Fungal Infections and Studies
- Chemical synthesis and alkaloids
- Phytochemicals and Medicinal Plants
- Traditional and Medicinal Uses of Annonaceae
- Plant biochemistry and biosynthesis
- Insect Pest Control Strategies
- Cannabis and Cannabinoid Research
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Venomous Animal Envenomation and Studies
- Psidium guajava Extracts and Applications
- Ethnobotanical and Medicinal Plants Studies
- Plant-Microbe Interactions and Immunity
- Medicinal Plants and Neuroprotection
- Natural product bioactivities and synthesis
- Chemical Synthesis and Analysis
- Malaria Research and Control
- Pain Mechanisms and Treatments
- Phytochemicals and Antioxidant Activities
Fundação Oswaldo Cruz
2016-2025
Universidade Federal de Ouro Preto
2024
Natura (Brazil)
2018
University of Münster
2006-2017
Ezequiel Dias Foundation
2011-2012
Multifunctional l-amino acid oxidases (LAAOs) occur widely in snake venoms. The l-AAO from Bothrops leucurus (Bl-LAAO) venom was purified using a combination of molecular exclusion and ion-exchange chromatographies. We report some biochemical features Bl-LAAO associated with its effect on platelet function cytotoxicity. is 60 kDa monomeric glycoprotein. Its N-terminal sequence shows high homology to other members the snake-venom LAAO family. catalyzes oxidative deamination acids generation...
Abstract Background The worldwide epidemics of diseases as dengue and Zika have triggered an intense effort to repurpose drugs search for novel antivirals treat patients no approved these are currently available. Our aim was screen plant-derived extracts identify isolate compounds with antiviral properties against virus (DENV) (ZIKV). Methods Seven thousand plant were screened in vitro their DENV-2 ZIKV by viral cytopathic effect reduction followed the...
BACKGROUND In a screen of extracts from plants and fungi to detect antileishmanial activity, we found that the ethyl acetate extract fungus Nectria pseudotrichia, isolated tree Caesalpinia echinata (Brazilwood), is promising source bioactive compounds. OBJECTIVES The aims this study were isolate determine chemical structures compounds responsible for activity organic N. pseudotrichia. METHODS Compounds by chromatographic fractionation using semi-preparative high-performance liquid...
Abstract BACKGROUND Using plant‐based extracts and their constituents has been suggested as an alternative tool to replace or integrate with the synthetic compounds used manage insect pests. Here, we evaluated potential of obtained from Ficus carica Linn (Moraceae) branches leaves against Neotropical brown stink bug, Euschistus heros , one most prevalent pests in soybean fields. We further isolated toxicity extracts' major components E. . Additionally, by using computational docking analysis...
Plant extracts are complex mixtures that difficult to characterize, and mass spectrometry is one of the main techniques currently used in dereplication processes.
Abstract Fridericia formosa (Bureau) L.G. Lohmann (Bignonaceae) is a neotropical liana species found in the Cerrado biome Brazil. It has been of great interest to scientific community due its potential as source new antivirals, including xanthones derived from mangiferin. In this context, present study aimed characterize and quantify ethanol extract using high performance liquid chromatography. Additionally, antiviral activity against Chikungunya, Zika, Mayaro viruses was evaluated. The...
Schinus terebinthifolius is a medicinal plant with biological in vitro activity against clinically relevant parasites such as Leishmania amazonensis and L. chagasi. Considering its antiparasitic activity, this work aimed to investigate the effects of S. fractions P. falciparum using SYBR fluorescence tests, cytotoxicity towards monkey kidney cells efficacy malaria murine model berghei infection. For first time, screening results several extracts are reported herein. Five out 16 obtained from...
Several species of Aspidosperma plants are referred to as remedies for the treatment malaria, especially nitidum. pyrifolium, also a medicinal plant, is used natural anti-inflammatory. Its fractionated extracts were assayed in vitro activity against malaria parasites and cytotoxicity. pyrifolium was evaluated Plasmodium falciparum using vitro. Toxicity towards human hepatoma cells, monkey kidney cells or monocytes freshly isolated from peripheral blood assessed. Anti-malarial selected...
To evaluate the antifungal activity of extracts Chamaecostus cuspidatus against Candida and Trichophyton species. Crude ethanol leaves, stems rhizomes were prepared evaluated for antimicrobial activity. Only extract (RE) showed but had no inhibitory effect bacteria (Staphylococcus aureus Escherichia coli). The RE was then submitted to liquid‐liquid partition with hexane (Hex), dichloromethane, chloroform, ethyl acetate water. Hex fraction (Hex Fr) from found have best effect. Three known...
Millingtonia hortensis L.f. and Oroxylum indicum (L.) Kurz (Bignoniaceae) are native species from the Asian continent. They popularly used in traditional medicine their extracts rich flavonoids. In this work, ethanolic of stems leaves these were evaluated against Chikungunya, Zika Mayaro virus. The subjected to analysis by ultra-efficient liquid chromatography coupled mass spectrometry. Additionally, M. extract was fractionated, leading isolation hispidulin. Anti-arboviral activity three...
Fungi of the genus Paracoccidioides are responsible for paracoccidioidomycosis. The occurrence drug toxicity and relapse in this disease justify development new antifungal agents. Compounds extracted from fungal extract have showing activity. Extracts 78 fungi isolated rocks Atacama Desert were tested a microdilution assay against brasiliensis Pb18. Approximately 18% (5) extracts showed minimum inhibitory concentration (MIC) values≤ 125.0 µg/mL. Among these, fungus UFMGCB 8030 demonstrated...
To investigate the herbicidal potential of 2,5-diketopiperazines (2,5-DKPs), we applied a known protocol to produce series 2,5-DKPs through intramolecular N-alkylation Ugi adducts. However, method was not successful for cyclization adducts presenting aromatic rings with some substituents at ortho position. Results from DFT calculations showed that presence voluminous groups position benzene ring results in destabilization transition structure. Lower activation enthalpies SN2-type were...
Mauritia flexuosa Linnaeus filius (buriti or aguage; Arecaceae) is a palm used by traditional medicine in Brazil to treat dysentery and diarrhea. Our group showed that the soluble dichloromethane (CH2 Cl2 ) fraction from EtOH extract M. stems inhibited growth of methicillin-susceptible Staphylococcus aureus (MSSA) methicillin-resistant S. (MRSA) it rich phenolic compounds. This study aimed isolate new compounds CH2 with vitro antibacterial activity. The crude was fractionated gel permeation...
Malaria, Chagas disease, and leishmaniasis are tropical diseases caused by protozoan parasites of the genera Plasmodium, Trypanosoma Leishmania, respectively. These constitute a major burden on public health in several regions worldwide, mainly affecting low-income populations economically poor countries. Severe side effects currently available drug treatments emergence resistant need to be addressed development novel candidates. Natural 2,5-Diketopiperazines (2,5-DKPs) N-heterocyclic...
Cannabidiol (CBD) is a substance that exerts several therapeutic actions, including analgesia. CBD generally administered orally, but its poor water solubility and metabolism impair bioavailability. Thus, the development of molecules with better pharmacokinetic profile from cannabidiol becomes an interesting strategy for design novel analgesic drugs relief painful conditions are difficult to manage clinically, such as neuropathic pain. In present study, unprecedented analogue (1) was...
(DC) is an important botanical source of Brazilian green propolis and have many compounds with potential antihypertensive activity. However, little known about the specific properties DC, or mechanisms involved. Here we aimed to chemically characterise ethanolic DC extract (eDC), test its involvement neurogenic using animal model salt-dependent hypertension. The chemical analysis eDC revealed presence compounds. Administering in a nanoemulsion formulation (25 50 mg/kg) effectively normalised...
Opportunistic fungal infections represent a global health problem, mainly for immunocompromised individuals. New therapeutical options are needed since several strains show resistance to clinically available antifungal agents. 2-Thiazolylhydrazones well-known as potent compounds against Candida and Cryptococcus species. A scaffold-focused drug design using machine-learning models was established optimize the 2-thiazolylhydrazone skeleton obtain novel with higher potency, better solubility in...
Mauritia flexuosa L.f. (Arecaceae), commonly known as the buriti palm, is used in traditional medicine Brazil. Oil from fruits for wound healing of skin burns and an anti rheumatic agent. The stem pith to treat dysentery diarrhea. aim this study was evaluate vitro antibacterial cytotoxic activities M. extracts fractions. Crude ethanol (EtOH) fruits, leaves, stems were submitted liquid-liquid partition yield four different soluble fractions: hexane (Hex), dichloromethane (DCM), ethyl acetate...