A5039273887- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Antimicrobial Peptides and Activities
- Fungal Plant Pathogen Control
Universidade Federal de Minas Gerais
2021-2025
Cryptococcosis is a severe fungal infection primarily caused by two encapsulated yeasts: Cryptococcus neoformans and C. gattii. The most significant complication cryptococcal meningitis, where the fungus crosses blood-brain barrier, leading to brain infection. Current treatments, which include amphotericin B flucytosine or fluconazole, are often toxic not very effective. Therefore, there pressing need for new antifungal agents. This study screened 30 thiazole derivatives their activity...
Opportunistic fungal infections represent a global health problem, mainly for immunocompromised individuals. New therapeutical options are needed since several strains show resistance to clinically available antifungal agents. 2-Thiazolylhydrazones well-known as potent compounds against Candida and Cryptococcus species. A scaffold-focused drug design using machine-learning models was established optimize the 2-thiazolylhydrazone skeleton obtain novel with higher potency, better solubility in...
Abstract Dermatophytosis is the most common human skin infection worldwide caused by dermatophytes, such as Trichophyton interdigitale and rubrum. Itraconazole (ITZ) one of main antifungals used to treat these infections. However, especially for onychomycosis, treatment requires long-term regimens, increasing possibility drug resistance. We evaluated effects ITZ in physiology, virulence, interaction T. with phagocytes mice cutaneous infection. In a screening test, fungal growth presence led...
Abstract Microorganisms that cause pneumonia and translocate to the central nervous system (CNS) are responsible for high mortality worldwide. The fungus Cryptococcus gattii (Cg) bacteria Streptococcus pneumoniae (Sp) target same infection organs. This study aimed investigate consequences of secondary Sp during murine cryptococcosis. Mice infected with after Cg showed significantly increased lethality a drop in scores motor behaviour, neuropsychiatric status autonomous function. Previous...
Cryptococcosis affects more than 220,000 patients/year, with high mortality even when the standard treatment [amphotericin B (AMB), 5-flucytosin (5-FC) and fluconazole] is used. AMB presents toxicity 5-FC not currently available in Brazil. In a pre-clinical study, pioglitazone (PIO - an antidiabetic drug) decreased lead to increased mice survival, reduced morbidity fungal burden brain lungs. The aim of this trial evaluate efficacy safety PIO combined antifungal for human cryptococcosis.A...