A5019071901- Synthesis and Biological Evaluation
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Synthesis and biological activity
- Fungal Plant Pathogen Control
- Essential Oils and Antimicrobial Activity
- Insect Pest Control Strategies
- Insect and Pesticide Research
- Antifungal resistance and susceptibility
- Metal complexes synthesis and properties
- Microbial Natural Products and Biosynthesis
- Analytical Chemistry and Chromatography
- Psidium guajava Extracts and Applications
- Biochemical and Molecular Research
- Treatment of Major Depression
- Piperaceae Chemical and Biological Studies
- Organometallic Compounds Synthesis and Characterization
- Peptidase Inhibition and Analysis
- Fungal Infections and Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Tuberculosis Research and Epidemiology
- Malaria Research and Control
- thermodynamics and calorimetric analyses
Universidade Federal de Ouro Preto
2019-2024
Universidade Federal de Minas Gerais
2013-2023
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2019
Ministry of Education
2019
Depression has a multifactorial etiology that arises from environmental, psychological, genetic, and biological factors. Environmental stress genetic factors acting through immunological endocrine responses generate structural functional changes in the brain, inducing neurogenesis neurotransmission dysfunction. Terpineol, monoterpenoid alcohol, shown immunomodulatory neuroprotective effects, but there is no report about its antidepressant potential. Herein, we used single lipopolysaccharide...
ABSTRACT The aims of this study were to synthesize a series thiosemicarbazones and their thiazole derivatives, investigate cytotoxic activity against three human cancers normal (Vero cells) cell lines, evaluate the pro-apoptotic potential most active compounds. Materials Methods: obtained by reacting an aromatic aldehyde with thiosemicarbazide (yield 71-96%), which subjected cyclization α-bromoacetophenone yield required heterocycles 63-100%). All synthesized compounds screened at 50 µM...
Abstract Quantitative nuclear magnetic resonance (qNMR) is an analytical technique that offers numerous advantages in pharmaceutical applications including minimum sample preparation and rapid data collection times with no need for response factor corrections, being a powerful tool assaying drug content both discovery early development. In the present work, we have applied qNMR, using internal standard electronic reference to access vivo concentrations 2 calibration methods, assess purity of...
Chagas disease (CD) is a worldwide public health problem, and the drugs available for its treatment have severe limitations. Red propolis natural extract known high content of phenolic compounds having activity against T. cruzi. The aim this study was to investigate trypanocidal potential red isolate, identify, indicate mode action bioactive compounds. results revealed that total 15.4 mg GAE/g, flavonoids were 7.2 QE/g. fractionated through liquid–liquid partitioning, samples evaluated using...
Opportunistic fungal infections represent a global health problem, mainly for immunocompromised individuals. New therapeutical options are needed since several strains show resistance to clinically available antifungal agents. 2-Thiazolylhydrazones well-known as potent compounds against Candida and Cryptococcus species. A scaffold-focused drug design using machine-learning models was established optimize the 2-thiazolylhydrazone skeleton obtain novel with higher potency, better solubility in...
This work describes the synthesis, anti-Candida, and molecular modeling studies of eighteen new glucosyl-1,2,3-triazoles derived from eugenol correlated phenols. The compounds were characterized by combined Fourier Transform Infrared, 1 H 13 C nuclear magnetic resonance spectroscopy high-resolution mass spectrometry. synthesized did not show significant cytotoxicity against healthy fibroblast human cells (MCR-5) providing interesting selectivity indexes (SI) to active compounds. Considering...