A5033762330- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Phytochemistry and Biological Activities
- Rural Development and Agriculture
- Traditional and Medicinal Uses of Annonaceae
- Viral Infections and Outbreaks Research
- Agricultural and Food Sciences
- vaccines and immunoinformatics approaches
- Insect Pest Control Strategies
- Virology and Viral Diseases
- Insect symbiosis and bacterial influences
- Agriculture, Land Use, Rural Development
- Natural product bioactivities and synthesis
- Soil Management and Crop Yield
- COVID-19 Clinical Research Studies
- Nanotechnology research and applications
- Alcohol Consumption and Health Effects
- Sulfur-Based Synthesis Techniques
- Protease and Inhibitor Mechanisms
- Machine Learning in Bioinformatics
- Mangiferin and Mango Extracts
- S100 Proteins and Annexins
- Plant-derived Lignans Synthesis and Bioactivity
Universidade Federal de Ouro Preto
2014-2024
Harvard University
2024
Fundação Oswaldo Cruz
2011
Universidade Federal de Minas Gerais
2005-2011
In Brazil, dengue epidemics erupt sporadically throughout the country and it is unclear if outbreaks may initiate a sustainable transmission cycle. There are few studies evaluating ability of Brazilian Aedes aegypti populations to transmit virus (DENV). The aim this study was compare DENV susceptibility field-captured Ae. from nine distinct geographic areas city Belo Horizonte in 2009 2011. Infection Rate (IR), Vector Competence (VC) Disseminated (DIR) were determined. eggs each region...
Mayaro virus (MAYV) is a neglected tropical arbovirus that causes febrile syndrome sometimes accompanied by incapacitating arthritis/arthralgia. The pathogenesis of MAYV has not been completely defined and oxidative stress mediated an increase in reactive oxygen species (ROS) and/or depletion antioxidant defences found to contribute several aspects viral disease. To investigate whether induced host cells, we monitored ROS production, markers at different time points after infection. Our...
Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity have allowed for invasion circulation of Zika (ZIKV) in the same areas. People living arbovirus-endemic regions been simultaneously infected with ≥2 arboviruses. A. mosquitoes from Manaus, capital city Amazonas State Brazil, were coinfected circulating strains DENV ZIKV. The vectors bite BALB/c mice. Manaus is highly monoinfection coinfection ZIKV capable cotransmitting both pathogens by bite....
The first outbreak of Zika virus (ZIKV) infection in the Americas, especially Brazil, was reported 2015. Fever, headache, rash, and conjunctivitis are common symptoms ZIKV infection. Unexpected clinical outcomes, such as microcephaly Guillain-Barré syndrome, have also been reported. recent spread its association with severe illness has created an urgent need to understand pathogenesis find potential therapeutic targets. Studies show that some viruses, including Flavivirus, trigger oxidative...
Oropouche virus (OROV) is the aetiological agent of fever, symptoms which are common to most arboviruses, such as headache, malaise, nausea and vomiting. More than half a million people have been infected with OROV since its isolation in 1955. Although fever classified neglected emerging disease, date, there no antiviral drugs or vaccines available against infection little known about pathogenicity. Therefore, it essential elucidate possible mechanisms involved pathogenesis. Since oxidative...
Zika disease has transformed into a serious global health problem due to the rapid spread of arbovirus and alarming severity including congenital complications, microcephaly Guillain-Barré syndrome. virus (ZIKV) is primarily transmitted humans through bite an infective mosquito, with Aedes aegypti being main vector.We successfully developed ZIKV experimental transmission model by single infectious Ae. laboratory mouse using circulating Brazilian strains both vector. Mosquitoes were orally...
Zika virus (ZIKV) has emerged as a globally important arbovirus and been reported from all states of Brazil. The is primarily transmitted to humans through the bite an infective Aedes aegypti (Linnaeus, 1762) or albopictus (Skuse, 1895). However, it know if ZIKV transmission also occurs Ae. infected eggs her offspring. Therefore, dengue (DENV) free colony was established collected in Manaus maintained until third-fourth generation order conduct vertical (VT) experiments which used infectious...
Plant extracts are complex mixtures that difficult to characterize, and mass spectrometry is one of the main techniques currently used in dereplication processes.
Abstract Fridericia formosa (Bureau) L.G. Lohmann (Bignonaceae) is a neotropical liana species found in the Cerrado biome Brazil. It has been of great interest to scientific community due its potential as source new antivirals, including xanthones derived from mangiferin. In this context, present study aimed characterize and quantify ethanol extract using high performance liquid chromatography. Additionally, antiviral activity against Chikungunya, Zika, Mayaro viruses was evaluated. The...
Background: Diabetes Mellitus (DM) is an important chronic disease that occurs worldwide. Aims: This study aims to investigate how the use of FreeStyle® Libre system in Unified Health System (SUS) patients impacts diabetes parameters who receive education on proper insulin administration and continuous monitoring device, as well this affects without any concomitant multidisciplinary support Sergipe, Brazil. Methods: We conducted a prospective randomized clinic Brazil, using flash method...
Introduction One of the markers aging is oxidative stress, a condition characterized by an increase in free radicals concomitant with reduction antioxidant defenses. Within this, resveratrol compound that has been shown to act as potent antioxidant. However, few studies highlight cellular signaling pathways are activated or inhibited during and responsible for this biological effect. Aim To verify profile (5 μM) leukocytes from donors different age groups. Methods The project was approved...
Brazil reported the majority of dengue cases in Americas during last two decades, where occurrence human is exclusively attributed to Aedes (Stegomyia) aegypti (Linnaeus). Nowadays, other recognized Dengue virus (DENV) vector Asian countries, albopictus (Skuse), has been detected more than half 5565 Brazilian municipalities. Therefore, aim present study was investigate presence of, and determine Ae. albopictus' dynamics influenced by spatiotemporal characteristics a dengue-endemic risk city...
Zika virus (ZIKV) epidemic and its association with severe neurological syndromes have raised worldwide concern. Despite the great clinical relevance of this infection, no vaccine or specific treatment is available search for antiviral compounds against ZIKV extremely necessary. Several natural compounds, such as silymarin, exhibit antioxidant, hepatoprotective, properties; however, potential compound remains partially investigated. Therefore, objective study was to evaluate in vitro...
Abstract Background Plant species from the genus Tecoma are found in tropical and subtropical regions around world. Some of them grown as ornamental plants others can be used medicinal plants. In present study, ethanolic extracts trunks leaves were tested vitro using assays against Zika virus. Methods There was a total 8 obtained different anatomical parts three species. The castaneifolia , T. garrocha stans var. angustata prepared by percolation with ethanol. antiviral activity assayed...
Abstract Background Aedes aegypti is a highly competent vector in the transmission of arboviruses, such as chikungunya, dengue, Zika, and yellow fever viruses, causes single coinfections populations tropical countries. Methods The infection rate, viral abundance (VA), competence (VC), disseminated infection, survival rate were recorded after multiple infections with 15 combinations arboviruses. Results Infection rates 100% all experiments, except 1 triple coinfection that presented 50%. VC...