A5037049618- Mosquito-borne diseases and control
- Research on Leishmaniasis Studies
- Viral Infections and Vectors
- Trypanosoma species research and implications
- Bacteriophages and microbial interactions
- Parasites and Host Interactions
- Malaria Research and Control
- Poxvirus research and outbreaks
- Essential Oils and Antimicrobial Activity
- Insect Pest Control Strategies
- Insect and Pesticide Research
- vaccines and immunoinformatics approaches
- Phytochemistry Medicinal Plant Applications
- Bacillus and Francisella bacterial research
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Transgenic Plants and Applications
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Plant Virus Research Studies
- Plant Pathogenic Bacteria Studies
- Healthcare Regulation
- Virus-based gene therapy research
- Fish biology, ecology, and behavior
- Education during COVID-19 pandemic
Federal University of São João del-Rei
2013-2023
Centro Nacional de Endemias
2016
Recombinant multiepitope proteins (RMPs) are a promising alternative for application in diagnostic tests and, given their wide the most diverse diseases, this review article aims to survey use of these antigens diagnosis, as well discuss main points surrounding antigens. RMPs usually consisting linear, immunodominant, and phylogenetically conserved epitopes, has been applied experimental diagnosis various human animal such leishmaniasis, brucellosis, cysticercosis, Chagas disease, hepatitis,...
Mayaro virus (MAYV) is a sublethal arbovirus transmitted by mosquitoes with possible installation of an urban cycle in the Americas. Its infection causes disabling arthralgia, and still, there no vaccine or treatment to it. We recently investigated nearly 600 compounds molecular docking identified epicatechin as potent antiviral against MAYV. The root extract Maytenus imbricata showed anti-MAYV activity two isolated from this plant were also evaluated vitro. Proanthocyanidin (PAC), dimer...
Infections caused by multidrug-resistant bacteria are a problem of public health, turning the search for natural products an alternative to antibiotics great importance. The aim this study was investigate in vitro antimicrobial activities Hymenaea courbaril and Stryphnodendron adstringens against bacterial clinical isolates. crude extracts both vegetal species showed bacteriostatic activity almost all evaluated, with minimum inhibitory concentration (MIC) ranging from 125 1250 µg/ml....
visceral leishmaniasis (VL) is a critical public health problem in over ninety countries. The control measures adopted Brazil have been insufficient when it comes to preventing the spread of this overlooked disease. In context, precise diagnosis VL dogs and humans could help reduce number cases Distinct studies for used single recombinant proteins serological assays; however, results variable, mainly relation sensitivity antigens. development multiepitope-based be relevant solving such...
Chagas disease remains a neglected that is considered to be public health problem. The early diagnosis of cases important improve the prognosis infected patients and prevent transmission. Serological tests are method choice for diagnosis. However, two serological currently recommended confirm positive cases. In this sense, more sensitive specific need developed overcome these current problems. This study aimed develop new recombinant multiepitope protein disease, hereafter named rTC. rTC was...
Abstract Objective To entomologically monitor Aedes spp. and correlate the presence of these vectors with recent epidemic dengue in Divinopolis, Minas Gerais State, Brazil. Methods Ovitraps were installed at 44 points city, covering six urban areas, from May 2011 to 2012. After collection, eggs incubated until hatching. In 4th stage development, larvae classified as Ae. aegypti or albopictus . Results total, 25 633 collected. February was month highest incidence, 5635 collected a hatching...
Background: The need to identify new antimicrobial drugs that present different mechanisms of action is urgent. variety biological properties chalcones give them a potential therapeutic compounds. Chalcones' synthetic manipulations are investigated worldwide in search more powerful and efficient several infectious diseases' treatment. Objective: purpose this work was evaluate the antibacterial, antifungal, anti-dengue virus (DENV) ten triazole chalcones. Materials Methods: Triazole were used...
Dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen and made disease a major health concern worldwide. However, specific antiviral drugs against this arbovirose or vaccines are not yet available for treatment prevention. Thus, here we aimed to study activity of hydroethanolic extract, fraction ethyl acetate subfractions leaves Bauhinia holophylla (Fabaceae:Cercideae), native plant Brazilian Cerrado, DENV-2 by methylthiazolyldiphenyl-tetrazolium bromide (MTT) method in...
Schistosomiasis is a neglected tropical parasitic disease caused by trematode worms of the genus schistosoma, which affects approximately 240 million people worldwide. diagnosis can be performed parasitological, molecular, and/or immunological methods, however, development new diagnostic methods still essential to guide policy decisions, monitor trends and assess effectiveness interventions.
ABSTRACT Background Monkeypox is a global public health issue caused by the monkeypox virus (MPXV), belonging to Orthopoxvirus genus. As of October 28 2022, total 77,115 laboratory-confirmed cases and 3,610 probable cases, including 36 deaths, were reported, with 9,070 reported in Brazil, second most affected country. The need develop national technologies for rapid diagnosis emerging diseases mass testing population evident, as observed current SARS-CoV-2 pandemic. With that mind, this...
Stryphnodendron adstringens e Hymenaea courbaril são duas espécies vegetais comuns na região do cerrado brasileiro, tradicionalmente empregadas medicina popular). Neste estudo, foi demonstrada a atividade dos extratos hidroetanólicos brutos, obtidos das cascas destas plantas, contra o isolado clínico meticiclina-resistente Staphylococcus aureus (MRSA). A concentração inibitória mínima (CIM) determinada pelo método de microdiluição em caldo (CLSI) fracional (CIF) pela técnica checkerboard...
Background: Dengue fever has become a worldwide public health concern, threatening an estimated 40% of the world's population. However, most resource and focus are still put on malaria in Africa. statuses poorly recognized many African countries. Methods & Materials: This serological survey demonstrated dengue virus (DENV) transmission with serum samples collected from 78 pregnant women Democratic Republic Sao Tome Principe (DRSTP) during 2003 to 2004. Results: Immunofluorescence assay was...
Em 2010, foram notificados 268.440 casos de dengue em Minas Gerais, sendo mais de5 mil somente no município Divinópolis, MG. Logo, o monitoramento do vetor Dengue virus (DENV) é extrema importância para prevenir surgimento novos casos. Para isto, ovitrampas instaladas 26 domicílios distribuídos 19 setores censitários, agrupados três divisões: Classes “Baixa” (B), “Média” (M) e “Alta” (A). Os ovos coletados contados e, posteriormente, as larvas identificadas Aedes aegypti ou A. albopictus....
A Dengue é uma das mais importantes arboviroses causada pelo virus, e causa problemas de saúde pública mundial. É transmitida aos seres humanos por picadas fêmeas infectadas do mosquito Aedes aegypti albopictus. Atualmente, cerca 50 milhões pessoas são anualmente. Diante disso, a busca agentes antivirais contra o vírus extrema importância, vez que não existem ou vacinas tetravalentes para tratamento da doença. Sendo assim, objetivo deste trabalho avaliar citotoxicidade compostos tetrazólicos...
A COVID-19 é uma infecção altamente contagiosa e rapidamente se tornou pandemia. Um dos desafios enfrentados o diagnóstico, visto que os métodos utilizados possuem limitações, como a dependência de insumos importados. O objetivo desse estudo foi divulgar ações estratégias universidades institutos pesquisa para diagnóstico da no Brasil. Deste modo, realizada busca patentes INPI notícias em sites oficiais período 25 fevereiro 10 maio 2020. Além disso, análise comparativa das iniciativas...
Background: Visceral leishmaniasis (VL) is s critical public health problem in over ninety countries. The control measures adopted Brazil have been insufficient when it comes to preventing the spread of this neglected disease. In context, a precise diagnosis VL dogs and humans could help reduce number cases Distinct studies for used single recombinant proteins serological assays; however, results variable, mainly sensitivity antigens. development multiepitope-based be relevant solving such...
Background: Chagas disease is still a neglected considered public health problem. Early diagnosis of cases important to improve the prognosis infected patients and prevent transmission. Serological tests are method choice for diagnosis. However, two serological currently recommended confirm positive cases. In this sense, more sensitive specific need be developed overcome problems faced. This study aimed develop new recombinant multiepitope protein disease, hereafter named rTC. Methods: The...
O A. aegypti é o principal vetor do DENV. Em 2010, Divinópolis notificou mais de 5 mil casos da doença. Devido a escassez dados relacionados ao DENV, este trabalho tem como objetivo fazer um monitoramento Aedes sp. partir ovitrampas georreferenciadas. As foram distribuídas por 6 regiões em 44 pontos. Os ovos coletados contados, as larvas eclodidas, identificadas e os geoprocessados. Foram 25.633 ovos. Onde fevereiro/2012 obteve maior número (5.635). A taxa ecolsão foi 47%, sendo 72.3% 27.7%...
Atualmente, a bactéria Staphylococcus aureus tem se tornado resistente aos principais antibióticos disponíveis, sendo necessária descoberta de novos medicamentos. Assim, o objetivo deste trabalho foi avaliar atividade bacteriostática, através do método diluição em caldo, e bactericida vinte dois compostos glicídicos sintetizados frente à aureus. Os resultados obtidos demonstraram que compostos, denominados CABN (derivado beta- naftol) PROP benzamidina), apresentam bacteriostática na...
Tendo em vista que a dengue tornou-se um sério problema de saúde pública e, por isto, necessidade se conhecer os diferentes aspectos epidemiológicos do vetor e vírus, diversos estudos estão sendo desenvolvidos com o objetivo esclarecer fatores influenciam na quantidade mosquitos compõem uma população vetora. As características socioeconômicas culturais têm sido alvos buscam estabelecer correlações entre as mesmas epidemiologia da doença. Este é dos objetivos presente trabalho, compara ovos...
Introdução: A COVID-19 é uma doença de interesse mundial. Diante disso, há um esforço globalizado no desenvolvimentode produtos/soluções que possam apoiar a sociedade neste momento. Objetivo: O objetivo desse trabalho foi relatar as ações e iniciativas algumas startups brasileiras, destinadas ao combate da COVID-19. Método: Para isso, pesquisa assistemática em plataformas sites notícias realizada, entre 1 março 5 junho 2020, 71 foram identificadas diferentes categorias: antipropagação...