William Gustavo Lima

ORCID: 0000-0001-8946-9363
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About
Contact & Profiles
Research Areas
  • Antibiotic Resistance in Bacteria
  • Mosquito-borne diseases and control
  • Essential Oils and Antimicrobial Activity
  • Antimicrobial Peptides and Activities
  • Insect and Pesticide Research
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Bee Products Chemical Analysis
  • Phytochemistry Medicinal Plant Applications
  • Antifungal resistance and susceptibility
  • Antibiotic Use and Resistance
  • Biochemical and Structural Characterization
  • Regulation of Appetite and Obesity
  • Bacterial biofilms and quorum sensing
  • Malaria Research and Control
  • Synthesis and Biological Evaluation
  • Vibrio bacteria research studies
  • Viral Infections and Vectors
  • Healthcare and Venom Research
  • Antimicrobial agents and applications
  • Antimicrobial Resistance in Staphylococcus
  • Synthesis and biological activity
  • Neuropeptides and Animal Physiology
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Microbial Natural Products and Biosynthesis
  • Phytochemistry and Biological Activities

Universidade Federal de Minas Gerais
2019-2024

Grupo Santa Casa de Belo Horizonte
2023-2024

Santa Casa Hospital
2023

Federal University of São João del-Rei
2013-2022

National Council for Scientific and Technological Development
2020-2022

ORCID
2020

Universidade do Estado de Minas Gerais
2019

Rede de Química e Tecnologia
2016

Kawasaki Hospital
2001

Cochlospermum regium is a shrub used in folk medicine to treat infection diseases. However, limited information are available regarding the antimicrobial mechanism of action, synergic effect major phytochemical components this specie, and it spectrum activity. Here, we aimed investigate activity its ethyl acetate fraction (EtOAc) from roots together with some constituents previously isolated commercially available, understand possible pharmacological interactions between these components....

10.1016/j.sajb.2017.11.010 article EN cc-by South African Journal of Botany 2017-11-26

Introduction: COVID-19 is a viral disease that has affected almost 21 million people worldwide. The lethality and considerable morbidity, high contagion lack of specific drugs against COVID-19, generated fear enhancing the habit self-medication by Brazilian people. Objectives: This review aims to address critical issues related irrational use medicines medicinal plants infection caused novel coronavirus. Results: placement fake news on social media, dissemination preliminary scientific...

10.29327/226760.2.3-5 article EN cc-by Brazilian Journal of Health and Pharmacy 2020-01-01

The medical importance of intra-abdominal candidiasis (IAC) contrasts with the limited number pharmacological treatment options available and increasing rate resistance to antifungal drugs. Thus, repositioning compounds in clinical use can contribute broadening possibilities for this infection. Statins, a class drugs used reduce cardiovascular event risk, have shown antiparasitic, antibacterial, antiviral activities; however, their effects remain poorly studied. In context, present study...

10.1016/j.biopha.2018.12.076 article EN Biomedicine & Pharmacotherapy 2018-12-24

The NS2B-NS3 protease has been identified as an attractive target for drug development against Zika virus (ZIKV) and combined repurposing structure-based virtual screening improved the of antiviral drugs. In this study, we performed a 1861 Food Administration (FDA) approved drugs available in DrugBank by selection docking validation crystal structure ZIKV (PDB ID 5H4I ) using Glide DOCK 6 software. antihistaminic chlorcyclizine (Grid score -24.8 kcal/mol) exhibited most promising interaction...

10.1021/acs.jcim.9b00933 article EN Journal of Chemical Information and Modeling 2019-12-18

The urgent global health challenge posed by methicillin-resistant Staphylococcus aureus (MRSA) infections demands effective solutions. Antimicrobial peptides (AMPs) represent promising tools of research new antibacterial agents and LyeTx I mn∆K, a short synthetic peptide based on the Lycosa erythrognatha spider venom, is good representative. This study focused analyzing some antimicrobial activities including minimum inhibitory bactericidal concentrations, synergy resensitization assays,...

10.20944/preprints202401.2063.v1 preprint EN 2024-01-30
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