A5074920226- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Antimicrobial Peptides and Activities
- Venomous Animal Envenomation and Studies
- Neuropeptides and Animal Physiology
- Biochemical and Structural Characterization
- Inhalation and Respiratory Drug Delivery
- Chemical Synthesis and Analysis
- Herpesvirus Infections and Treatments
- Neurobiology and Insect Physiology Research
- Angiogenesis and VEGF in Cancer
- Respiratory viral infections research
- Cell Adhesion Molecules Research
- Insect and Pesticide Research
- Herbal Medicine Research Studies
- Beetle Biology and Toxicology Studies
- Blood Coagulation and Thrombosis Mechanisms
- Urticaria and Related Conditions
- Protein purification and stability
- Pharmaceutical studies and practices
- Healthcare and Venom Research
Universidade Federal de Minas Gerais
2020-2024
The urgent global health challenge posed by methicillin-resistant Staphylococcus aureus (MRSA) infections demands effective solutions. Antimicrobial peptides (AMPs) represent promising tools of research new antibacterial agents and LyeTx I mn∆K, a short synthetic peptide based on the Lycosa erythrognatha spider venom, is good representative. This study focused analyzing some antimicrobial activities including minimum inhibitory bactericidal concentrations, synergy resensitization assays,...
Background and Purpose Bradykinin (BK‐(1–9)) is an endogenous nonapeptide involved in multiple physiological pathological processes. Peptide fragments of bradykinin are believed to be biologically inactive. We have now tested the two major peptide human animals. Experimental Approach BK peptides were quantified by MS male rats. NO release was from human, mouse rat cells loaded with DAF‐FM. Rat aortic rings used measure vascular reactivity. Changes BP HR measured conscious To evaluate...
Uveitis is a group of sight-threatening ocular inflammatory disorders, whose mainstay therapy associated with severe adverse events, prompting the investigation alternative treatments. The peptide melittin (MEL) major component Apis mellifera bee venom and presents anti-inflammatory antiangiogenic activities, possible application in ophthalmology. This work aims to investigate potential intravitreal MEL treatment diseases involving processes, especially uveitis. Safety was assessed retinal...
The urgent global health challenge posed by methicillin-resistant Staphylococcus aureus (MRSA) infections demands effective solutions. Antimicrobial peptides (AMPs) represent promising tools of research new antibacterial agents and LyeTx I mn∆K, a short synthetic peptide based on the Lycosa erythrognatha spider venom, is good representative. This study focused analyzing antimicrobial activities including minimum inhibitory bactericidal concentrations, synergy resensitization assays, lysis...
ABSTRACT Background and purpose Bradykinin [BK-(1-9)] is an endogenous peptide involved in many physiological pathological processes, such as cardiovascular homeostasis inflammation. The central dogma of the kallikrein-kinin system that BK-(1-9) fragments are biologically inactive. In this manuscript, we proposed to test whether these were indeed Experimental Approach Nitric oxide (NO) was quantified human, mouse rat cells loaded with DAF-FM after stimulation BK-(1-9), BK-(1-7), BK-(1-5)...
A PEGuilação, reação química de conjugação com a molécula polietilenoglicol (PEG) ou metil éter (mPEG), tem sido amplamente aplicada pelas indústrias farmacêuticas como estratégia melhoria das propriedades farmacocinéticas compostos bioativos. O PEG é um polímero que possui esqueleto poliéter quimicamente inerte e apresenta grupos hidroxilas (-OH) em suas extremidades. Assim, o para tornar-se apto reagente deve ser ativado grupo funcional seja reativo. Nesse sentido, bromoacetilação...
Background and purpose: Bradykinin [BK-(1-9)] is an endogenous nonapeptide involved in multiple physiological pathological processes. A long-held belief that peptide fragments of BK-(1-9) are biologically inactive. Here, we have tested the biological activities two major human animal systems. Experimental Approach: Levels BK peptides male Wistar rat plasma were quantified by mass spectrometric methods. Nitric oxide was human, mouse cells, loaded with DAF-FM. We used aortic rings from adult...
Objective: Bradykinin [BK-(1–9)] is an endogenous peptide involved in many physiological and pathological processes, such as cardiovascular homeostasis inflammation. The central dogma of the kallikrein-kinin system that BK-(1–9) fragments are biologically inactive. In this work, we proposed to test whether these were indeed Design method: Nitric oxide (NO) was quantified human, mouse rat cells loaded with DAF-FM after stimulation BK-(1–9), BK-(1–7), BK-(1–5) BK-(1–3). We used adult male...