A5053707993- Gene expression and cancer classification
- Genetic Neurodegenerative Diseases
- Genetic Associations and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- Lymphoma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Muscle Physiology and Disorders
- Viral-associated cancers and disorders
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Genomics and Diagnostics
- Cytomegalovirus and herpesvirus research
- Menopause: Health Impacts and Treatments
- Software Engineering and Design Patterns
- Genetic and phenotypic traits in livestock
- Chronic Lymphocytic Leukemia Research
- Plant Gene Expression Analysis
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Nerve injury and regeneration
- Bioinformatics and Genomic Networks
- Neonatal Respiratory Health Research
- Air Quality Monitoring and Forecasting
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
Medidata (United States)
2018-2024
Cornell University
2007-2022
Weill Cornell Medicine
2018-2020
Icahn School of Medicine at Mount Sinai
2011-2012
Allen Institute for Brain Science
2012
Abstract Estrogen receptor‐α (ERα), estrogen receptor‐β (ERβ), and progestin receptor (PR) immunoreactivities are localized to extranuclear sites in the rat hippocampal formation. Because rats mice respond differently estradiol treatment at a cellular level, present study examined distribution of ovarian hormone receptors dorsal formation mice. For this, antibodies ERα, ERβ, PR were by light electron immunomicroscopy male female across estrous cycle. Light microscopic examination mouse...
Little is known about human club cells, dome-shaped cells with dense cytoplasmic granules and microvilli that represent the major secretory of small airways (at least sixth-generation bronchi).To define ontogeny biology airway epithelium cell.The was sampled from normal lung by bronchoscopy brushing. Single-cell transcriptome analysis air-liquid interface culture were used to assess cell biology.We identified population unbiased clustering using single-cell sequencing. Principal component...
Idiopathic multicentric Castleman disease (iMCD) is a poorly understood hematologic disorder involving cytokine-induced polyclonal lymphoproliferation, systemic inflammation, and potentially fatal multiorgan failure. Although the etiology of iMCD unknown, interleukin-6 (IL-6) an established driver in approximately one-third patients. Anti-IL-6 therapy, siltuximab, only US Food Drug Administration-approved treatment. Few options exist for siltuximab nonresponders, no validated tests are...
Here, we report the generation and characterization of a novel Huntington’s disease (HD) mouse model BAC226Q by using bacterial artificial chromosome (BAC) system, expressing full-length human HTT with ~226 CAG-CAA repeats containing endogenous promoter regulatory elements. recapitulated full-spectrum age-dependent progressive HD-like phenotypes without unwanted erroneous phenotypes. mice developed normally, gradually exhibited psychiatric cognitive at 2 months. From 3 to 4 months, showed...
Epidemiologic studies have demonstrated that exposure to particulate matter ambient pollution has adverse effects on lung health, exacerbated by cigarette smoking. Particulate less than or equal 2.5 μm in aerodynamic diameter (PM
Genome-wide expression Quantitative Trait Loci (eQTL) studies in humans have provided numerous insights into the genetics of both gene and complex diseases. While majority eQTL identified genome-wide analyses impact a single gene, that many genes are particularly valuable for network modeling disease analysis. To enable identification such broad eQTL, we introduce CONFETI: Confounding Factor Estimation Through Independent component CONFETI is designed to address two conflicting issues when...
Intravenous immunoglobulin (IVIg) is a polyclonal human IgG preparation that contains antibodies against beta amyloid (Aβ). In our Phase I immunotherapy trial involving eight patients with mild to moderate Alzheimer's disease (AD), IVIg improved cognitive function, increased Aβ levels in plasma and decreased the cerebrospinal fluid (CSF). However, magnitude of change Aβ40 Aβ42 after treatment was unexpectedly large relative known titers anti-Aβ IVIg. To clarify mechanisms responsible for...
The goal of this work is to reduce the amount manual required go from data capture regulatory submission. It will be shown that use Siamese networks allow for generation embeddings can used by traditional machine learning classifiers perform classification at much higher levels accuracy than standard approaches.
Abstract As genetic datasets increase in size, the fraction of samples with one or more close relatives grows rapidly, resulting sets mutually related individuals. We present DRUID—Deep Relatedness Utilizing Identity by Descent—a method that works inferring identical descent (IBD) sharing profile an ungenotyped ancestor a set relatives. Using this IBD profile, DRUID infers relatedness between unobserved ancestors and distant relatives, thereby combining information from multiple to remove...
e23195 Background: Clustering algorithms have identified subtypes of major cancers from analysis genome-wide gene expression (GE) and somatic mutation (SM) profiles. These almost never discover a proper subset cluster, recovered cluster that includes all the samples specific subtype. For breast cancer (BC), clustering profiles has been unable to triple negatives (TNs), TN subtypes, or other subtypes. Methods: To search for TNs, we applied new algorithm public domain GE SM data BC in The...
Abstract Here we report the generation and characterization of a novel Huntington’s disease (HD) mouse model BAC226Q by using bacterial artificial chromosome (BAC) system, expressing full-length human HTT with ∼226 CAG-CAA repeats containing endogenous promoter regulatory elements. recapitulated full-spectrum age-dependent progressive HD-like phenotypes without unwanted erroneous phenotypes. mice developed normally, gradually exhibited mood cognitive at 2 months. From 3-4 months, showed...