A5009060375- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Otitis Media and Relapsing Polychondritis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vasculitis and related conditions
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Parasitic Infections and Diagnostics
- Heparin-Induced Thrombocytopenia and Thrombosis
- Fusion materials and technologies
- Powder Metallurgy Techniques and Materials
- Advanced materials and composites
- Clusterin in disease pathology
- Cystic Fibrosis Research Advances
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- S100 Proteins and Annexins
University of Aberdeen
2013-2024
Institute of Medical Sciences
2019
Oak Ridge National Laboratory
2003
ABSTRACT Candida albicans is a major life-threatening human fungal pathogen in the immunocompromised host. Host defense against systemic infection relies heavily on capacity of professional phagocytes innate immune system to ingest and destroy cells. A number pathogens, including C. , have evolved mechanisms that attenuate efficiency phagosome-mediated inactivation, promoting their survival replication within Here we visualize host-pathogen interactions using live-cell imaging show viable,...
Innate immunity provides essential protection against life-threatening fungal infections. However, the outcomes of individual skirmishes between immune cells and pathogens are not a foregone conclusion because some have evolved mechanisms to evade phagocytic recognition, engulfment, killing. For example,
ABSTRACT An important first line of defense against Candida albicans infections is the killing fungal cells by professional phagocytes innate immune system, such as polymorphonuclear (PMNs) and macrophages. In this study, we employed live-cell video microscopy coupled with dynamic image analysis tools to provide insights into complexity C. phagocytosis when macrophages PMNs were incubated alone both phagocyte subsets present. When only one subtype, had a lower overall phagocytic capacity...
In this study, the human immune response mechanisms against Sporothrix brasiliensis and schenckii , two causative agents of animal sporotrichosis, were investigated. The interaction S. with monocyte-derived macrophages (hMDMs) was shown to be dependent on thermolabile serum complement protein C3, which facilitated phagocytosis yeast cells through opsonization. peptidorhamnomannan (PRM) component cell walls these yeasts found one their surfaces exposed pathogen-associated molecular pattern...
Neutrophils, monocytes and the endothelium are critical to ANCA-associated vasculitis (AAV) pathogenesis. This study aimed develop a 4-dimensional (4D) live-cell imaging system that would enable investigation of spatial temporal dynamics these cells in health disease. We further validate this using autologous donor serum from AAV patients polyclonal ANCA IgG, as well exploring its potential pre-clinical testing putative therapeutic compounds. Neutrophils were isolated peripheral venous blood...
ory ting pro-1) een ses um/ plasma levels of other cytokines are less clear.The assessment IL-27 may provide a better understanding its pathophysiology, and circulating act as biomarkers disease activity.Therefore, the aim study was to investigate utility serum in order assess activity patients with TA.Methods: 34 TA (32 female, 2 male) healthy controls male; mean age 29.3AE4.1 years) were enrolled this study.Patients divided into active inactive groups according Kerr scores.Twenty-one stage...