A5042307172- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Trypanosoma species research and implications
- Adenosine and Purinergic Signaling
- Enzyme Production and Characterization
- Synthesis and Biological Evaluation
- Microbial Metabolites in Food Biotechnology
- Click Chemistry and Applications
- Legume Nitrogen Fixing Symbiosis
- Organoselenium and organotellurium chemistry
- Receptor Mechanisms and Signaling
- Diet, Metabolism, and Disease
- Selenium in Biological Systems
- Biochemical and Molecular Research
- Calcium signaling and nucleotide metabolism
- Organophosphorus compounds synthesis
- Polyamine Metabolism and Applications
- Sulfur Compounds in Biology
- Pharmacological Receptor Mechanisms and Effects
- Lysosomal Storage Disorders Research
- Cystic Fibrosis Research Advances
- Chemical Synthesis and Analysis
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Organic Chemistry Synthesis Methods
- NF-κB Signaling Pathways
Consejo Nacional de Investigaciones Científicas y Técnicas
2006-2024
University of Buenos Aires
2007-2024
Fundación Ciencias Exactas y Naturales
2011-2024
Institute of Astronomy and Space Physics
2019
National Institutes of Health
1993-2000
National Institute of Diabetes and Digestive and Kidney Diseases
1993-1994
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-Activity Relationships of N6-Benzyladenosine-5'-uronamides as A3-Selective Adenosine AgonistsCarola Gallo-Rodriguez, Xiao-duo Ji, Neli Melman, Barry D. Siegman, Lawrence H. Sanders, Jeraldine Orlina, Bilha Fischer, Quanlong Pu, Mark E. Olah, and Cite this: J. Med. Chem. 1994, 37, 5, 636–646Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March...
An adenosine antagonist, 8‐(3‐chlorostyryl)caffeine (CSC), was shown previously to be 520‐fold selective for A 2a ‐adenosine receptors in radioligand binding assays the rat brain. In reversing agonist effects on adenylate cyclase, CSC 22‐fold pheochromocytoma cells ( K b 60 nM) vs. 1 adipocytes 1.3 μM). Administered i.p. NIH mice at a dose of mg/kg, shifted curve locomotor depression elicited by ‐selective APEC right (ED 50 value from 20 μg/kg 190 μg/kg). had no effect an ED CHA. alone 5...
The rat A3 adenosine receptor (AR) is a recently characterized AR subtype cloned from testis and brain cDNA libraries. N6-2-(4-Amino-3-[125I]iodophenyl)ethyladenosine, high affinity A1AR agonist, has served as the only radioligand available for study of A3AR. relatively low N6-2-(4-amino-3-[125I] iodophenyl)ethyladenosine A3AR its greater selectivity necessitate development more appropriate radioligands analysis. This report characterizes 125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine...
A novel adenosine receptor, the A3 has recently been cloned. We have systematically investigated hitherto largely unexplored structure-activity relationships (SARs) for binding at receptors, using 125I-N6-2-(4-aminophenyl)ethyladenosine as a radioligand and membranes from Chinese hamster ovary cells stably transfected with rat A3-cDNA. As is case A1 A2a substitutions N6 5' positions of adenosine, prototypic agonist ligand, may yield fairly potent compounds. However, highest affinity...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonistsKenneth A. Jacobson, Carola Gallo-Rodriguez, Neli Melman, Bilha Fischer, Michel Maillard, Andrew van Bergen, Philip J. M. Galen, and Yishai KartonCite this: Med. Chem. 1993, 36, 10, 1333–1342Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 1993https://doi.org/10.1021/jm00062a005RIGHTS & PERMISSIONSArticle...
The behavioral effects of a selective A 3 adenosine receptor agonist 3‐IB‐MECA ( N 6 ‐(3‐iodobenzyl)‐5'‐ ‐methylcarboxamidoadenosine) in mice and the localization radioligand binding sites mouse brain were examined. Low levels receptors detected various regions (hippocampus, cortex, cerebellum, striatum), using radioiodinated, high‐affinity ‐agonist [ 125 I]AB‐MECA ‐(3‐iodo‐4‐aminobenzyl)‐5'‐ ‐methylcarboxamidoadenosine). Scatchard analysis cerebellum showed that K d value for to was 1.39 ±...
Trypanosoma cruzi, the agent of Chagas disease, is a protozoan parasite transmitted to humans by blood-sucking triatomine vectors. However, and despite its utmost biological epidemiological relevance, T. cruzi development inside digestive tract insect remains poorly understood process.Here we showed that Gp35/50 kDa mucins, major surface glycoproteins from insect-dwelling forms, are involved in attachment internal cuticle rectal ampoule, critical step leading differentiation into...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTFirst Synthesis of β-d-Galf(1−4)GlcNAc, a Structural Unit Attached O-Glycosidically in Glycoproteins Trypanosoma cruziCarola Gallo-Rodriguez, Oscar Varela, and Rosa M. de LederkremerView Author Information Departamento Química Orgánica, Facultad Ciencias Exactas y Naturales, Universidad Buenos Aires, Ciudad Universitaria, Pabellón II, 1428 Argentina Cite this: J. Org. Chem. 1996, 61, 5, 1886–1889Publication Date (Web):March 8, 1996Publication History...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of trifluoromethyl and other substituents on activity xanthines at adenosine receptorsKenneth A. Jacobson, Dan Shi, Carola Gallo-Rodriguez, Malcolm Manning Jr., Christa Muller, John W. Daly, L. Neumeyer, Leonidas Kiriasis, Wolfgang PfleidererCite this: J. Med. Chem. 1993, 36, 18, 2639–2644Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September...
Abstract In this article we have focused on the use of selenium in catalysis along with proposed reaction mechanisms. With increasing interest chemistry, highlighted most significant features subject, mainly last years. Selenium-containing catalysts a key role many transformations; for example, oxidation reactions that are performed under very mild and controlled conditions. addition, utilizing weak selenium–oxygen bonding interaction has proved to be useful as catalytic approach specific...
The galactofuran is a crucial constituent of the cell wall mycobacteria. An efficient synthesis two trisaccharide units galactan described. strategy relies on use substituted d-galactono-1,4-lactones as precursors for internal and reducing galactofuranoses. Dec-9-enyl β-d-Galf-(1→6)-β-d-Galf-(1→5)-β-d-Galf (2) dec-9-enyl β-d-Galf-(1→5)-β-d-Galf-(1→6)-β-d-Galf (9) so far reported convenient substrates galactofuranosyl transferase, possibly useful immunological studies, were obtained by...
Several studies indicate that hyaluronan oligosaccharides (oHA) are able to modulate growth and cell survival in solid tumors; however, no have been undertaken analyze the effect of oHA on T-lymphoid disorders. In this work we showed were induce apoptosis lymphoma lines. Since PI3-K/Akt nuclear factor-κB (NF-κB) major factors involved anti-apoptotic pathways cells, hypothesized could through inhibition these pathways. identified by a method which allows characterization length using high pH...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStimulation by Alkylxanthines of Chloride Efflux in CFPAC-1 Cells Does Not Involve A1 Adenosine ReceptorsKenneth A. Jacobson, Colleen Guay-Broder, Philip J. M. van Galen, Carola Gallo-Rodriguez, Neli Melman, Marlene Ofer Eidelman, and Harvey B. PollardCite this: Biochemistry 1995, 34, 28, 9088–9094Publication Date (Print):July 18, 1995Publication History Published online1 May 2002Published inissue 18 July...
In a continuation of our studies on the characterization glycoproteins T. cruzi new galactofuranosyl disaccharides were synthesized. β-d-Galf-(1−3)-d-GlcNAc (1) was prepared by employing trichloroacetamidate procedure for glycosylation step. The mild conditions this reaction are appropriate condensation 2,3,5,6-tetra-O-benzoyl-β-d-galactofuranosyl (6) with acid-labile benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-α-d-glucopyranoside (3). On other hand, tin(IV) chloride promoted...
The synthesis of alpha-D-Galp-(1-->3)-beta-D-Galf-(1-->3)-D-Man, present in the type-2 glycoinositolphospholipids and core lipophosphoglycan Leishmania, is described. glycosyl aldonolactone approach, followed by reduction lactone with diisoamylborane, was utilized for introduction internal galactofuranosyl unit trichloroacetimidate method O-glycosidation reaction. A high-yield beta-D-Galf-(1-3)-D-Man unit, also lipopeptidophosphoglycan Trypanosoma cruzi, reported.