A5027806173- Carbohydrate Chemistry and Synthesis
- Trypanosoma species research and implications
- Glycosylation and Glycoproteins Research
- Lysosomal Storage Disorders Research
- Microbial Metabolites in Food Biotechnology
- Enzyme Production and Characterization
- Biochemical and Molecular Research
- Enzyme Catalysis and Immobilization
- Research on Leishmaniasis Studies
- Diet, Metabolism, and Disease
- Polyamine Metabolism and Applications
- Synthetic Organic Chemistry Methods
- Amino Acid Enzymes and Metabolism
- Synthesis of Organic Compounds
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Polysaccharides and Plant Cell Walls
- Toxin Mechanisms and Immunotoxins
- Fluorine in Organic Chemistry
- Lipid metabolism and biosynthesis
- Fungal Biology and Applications
- Oxidative Organic Chemistry Reactions
- Chemical synthesis and alkaloids
- Legume Nitrogen Fixing Symbiosis
- Traditional and Medicinal Uses of Annonaceae
Fundación Ciencias Exactas y Naturales
2011-2022
University of Buenos Aires
2010-2022
Consejo Nacional de Investigaciones Científicas y Técnicas
2008-2021
Institute of Astronomy and Space Physics
2012-2019
National University of General San Martín
2011
Universidad Nacional de La Plata
1999
Université Claude Bernard Lyon 1
1989
Centre National de la Recherche Scientifique
1989
Université Paris-Sud
1987
Universidade de São Paulo
1976
for this molecule has been reported (Previato,
Lipopeptidophosphoglycan, extracted from whole cells of epimastigote forms Trypanosoma cruzi , has now been shown to contain 12.6% fatty acids in addition the previously identified content neutral sugars (60%), glucosamine (0.8%), peptide (9.5%) and acid‐hydrolyzable phosphate (2%). The main are palmitic (6.9%) lignoceric (4.6%) acids. Stearic (0.55%), oleic (0.15%) myristic (0.18%) were also found. One third bound lipopeptidophosphoglycan as esters (14 mmol%) two thirds amides (28 mmol%)....
The protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, has a large number mucin molecules on its surface, whose expression is regulated during life cycle. These mucins are main acceptors sialic acid, monosaccharide that required by to infect and survive in mammalian host. A mucin-like gene family named TcMUC containing about 500 members been identified previously T. cruzi. can be divided into two subfamilies according presence or absence tandem repeats central region genes....
The lipopeptidophosphoglycan from Trypanosoma cruzi is a glycosylated inositol‐phosphoceramide isolated epimastigotes at the stationary phase of growth (4–5 days). We have now purified two similar glycoinositolphospholipids (glycoinositolphospholipid A and glycoinositolphospholipid B) after second day culture growth. [ 3 H]Palmitic acid was incorporated into 1‐ O ‐hexadecyl‐2‐ ‐palmitoylglycerol in ceramide B. lipids were released by incubation with glycosylphosphatidylinositol‐specific...
Trypanosoma cruzi, the agent of Chagas disease, is a protozoan parasite transmitted to humans by blood-sucking triatomine vectors. However, and despite its utmost biological epidemiological relevance, T. cruzi development inside digestive tract insect remains poorly understood process.Here we showed that Gp35/50 kDa mucins, major surface glycoproteins from insect-dwelling forms, are involved in attachment internal cuticle rectal ampoule, critical step leading differentiation into...
Beta-D-galactofuranosidase is a good chemotherapeutic target for the design of inhibitors, since beta-D-galactofuranose constituent important parasite glycoconjugates but not present in host mammals. With this aim, we have synthesized first time alkyl, benzyl and aryl 1-thio-beta-D-galactofuranosides by condensation penta-O-benzoyl-alpha,beta-D-galactofuranose with corresponding thiols, presence SnCl4as catalyst. The complete chemical spectroscopical characterization these compounds showed...
The trans-sialidase from the trypomastigote stage of Trypanosoma cruzi was metabolically labeled with [ 3 H]-palmitic acid and purified by immunoprecipitation a monodonal antibody. action PI-PLC on immunoprecipitate released lipid that analyzed TLC. Lyso-1- O -hexadecylglycerol N-palmitoyl-sphinganine were obtained in 1:3 ratio. A comparison GPI anchors present different stages T.cruzi made.
ABSTRACT Differentiation of Trypanosoma cruzi trypomastigotes to amastigotes inside myoblasts or in vitro, at low extracellular pH, the presence [ 3 H]palmitic acid H]inositol revealed differential labeling inositolphosphoceramide and phosphatidylinositol, suggesting that a remodeling process takes place both lipids. Using H-labeled phosphatidylinositol as substrates, we demonstrated association least five enzymatic activities with membranes trypomastigotes. These included phospholipase A 1...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTFirst Synthesis of β-d-Galf(1−4)GlcNAc, a Structural Unit Attached O-Glycosidically in Glycoproteins Trypanosoma cruziCarola Gallo-Rodriguez, Oscar Varela, and Rosa M. de LederkremerView Author Information Departamento Química Orgánica, Facultad Ciencias Exactas y Naturales, Universidad Buenos Aires, Ciudad Universitaria, Pabellón II, 1428 Argentina Cite this: J. Org. Chem. 1996, 61, 5, 1886–1889Publication Date (Web):March 8, 1996Publication History...