A5101788817- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Neuroscience and Neuropharmacology Research
- HIV-related health complications and treatments
- Toxin Mechanisms and Immunotoxins
- Lipid Membrane Structure and Behavior
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Plant-based Medicinal Research
Shanghai University of Traditional Chinese Medicine
2017-2021
In part because of their high drug loading, nanocrystals (NCs) have seen extensive use in delivery, particularly for insoluble or poorly soluble drugs. It remains a challenge, however, to prepare stable with tumor-targeting capability. Here, we designed novel preparation paclitaxel (PTX) efficient active properties. PTX NC was prepared using bottom-up method and modified both poly(ethylene glycol) (PEG) folic acid (FA) derivatives film hydration. The resulting NC@lipid–PEG–FA had rodlike...
To enhance the immunogenicity of model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a saponin adjuvant. reduce toxicity PD, OVA, and adjuvant were loaded together into liposomes before being incorporated dissolving microneedle array.OVA- PD-loaded (OVA-PD-Lipos) prepared using film dispersion method. Their uptake behavior, to mouse bone marrow dendritic cells (BMDCs), hemolytic activity rabbit red blood (RBCs) evaluated. The OVA-PD-Lipos array. chemical stability OVA...
In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine (TMP) is enhanced when combined with borneol (BN) in a microemulsion-based transdermal therapeutic system (ME-TTS). The formulation TMP BN microemulsion (TEM-BN-ME) was optimized skin permeation studies vitro following uniform experimental design. Male Sprague-Dawley rats were used for vivo pharmacokinetic tissue TMP-BN-ME-TTS. TMP-BN-ME-TTS treated had significantly higher (P < 0.05) Cmax...