A5101729765- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Sulfur Compounds in Biology
- MicroRNA in disease regulation
- Neuroscience of respiration and sleep
- Fatty Acid Research and Health
- Traumatic Brain Injury Research
- Genomics, phytochemicals, and oxidative stress
- Anesthesia and Neurotoxicity Research
- Neurobiology and Insect Physiology Research
- Cancer, Hypoxia, and Metabolism
- Photochromic and Fluorescence Chemistry
- Alzheimer's disease research and treatments
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Hepatitis C virus research
- High Altitude and Hypoxia
- Phytochemical Studies and Bioactivities
- Photoreceptor and optogenetics research
- Neurological Disease Mechanisms and Treatments
- Visual perception and processing mechanisms
- Curcumin's Biomedical Applications
Yuhuangding Hospital
2015-2024
Qingdao University
2017-2021
The present study aimed to investigate the protective effects of docosahexaenoic acid (DHA) on traumatic brain injury (TBI) in rats. A model TBI was induced by lateral fluid percussion adult rats and were randomly divided into TBI-model group, TBI-low DHA group TBI-high while other healthy assigned sham-operated group. Motor recovery tested with beam-walking trials at 2, 7 15 days post-TBI. Cognitive Morris water maze expression levels caspase-3, B-cell lymphoma 2 (Bcl-2) Bcl-2-associated X...
Abstract Docosahexaenoic acid (DHA) is verified to have neuroprotective effects on traumatic brain injury (TBI) rats by activating Nrf2 signaling pathway, but the role of NOX 2 in this effect has not been illuminated. So study explored TBI models treated with DHA, aiming complete mechanism DHA. rat were constructed or without DHA treatment, and H O -induced hippocampal neurons pretreated alone combination inhibitor brusatol. The neurological function, cognitive ability, cerebral edema degree...
Transient receptor potential ankyrin 1 (TRPA1) channel, as a nonselective ligand-gated cation channel robustly in dorsal root ganglion sensory neurons, is implicated sensing noxious stimuli and nociceptive signaling. However, small-molecule tools targeting TRPA1 lack temporal spatial resolution, limiting their use for validation of therapeutic target pain. In our previous work, we found that 4,4′-(diazene-1,2-diyl)dianiline (AB1) photoswitchable agonist, but the poor water solubility...
The purpose of our study was to explore the effects edaravone on rats with traumatic brain injury (TBI) and investigate underlying mechanism.All were separated randomly into 3 groups as follows: sham group (n = 25), TBI + 25). Edaravone administered intraperitoneally (i.p.) at a dose mg/kg 30 min, 12 h, 24 h after TBI. neurological impairment spatial cognitive function assessed by neurologic severity score (NSS) Morris water maze (MWM), respectively. Western blot reverse transcription...
Motivation: Most fMRI column studies don’t consider the potentially different laminar responses along cortical depth. Goal(s): In this work, we demonstrate feasibility of mapping ocular dominance columns (ODCs) at multiple depths in cat visual cortex using CBV-weighted fMRI. Approach: To enable monocular input to either eye a cat, customized goggle that can avoid light leakage and switch eyes easily. Results: By employing mesoscopic ultrahigh magnetic field (9.4 Tesla), observed...
Abstract Background: The goal of this investigation was to examine the expression changes H 2 S, IGF-1, and GH after TBI detect their roles TBI. Methods: In study, we first collected cerebrospinal fluid (CSF) plasma from patients at different times injury evaluated concentrations GH. vitro conditions were stimulated by using HT22 hippocampal neurons LPS-induced BV2 microglia cells. Models established controlled cortical impact (CCI) in vivo . CCK-8 assay, qRT-PCR ELISA used. Western blot...