Alexander C. Graf

ORCID: 0000-0002-5975-2819
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About
Contact & Profiles
Research Areas
  • Plasma Applications and Diagnostics
  • Antifungal resistance and susceptibility
  • Bacterial biofilms and quorum sensing
  • Polyamine Metabolism and Applications
  • Cystic Fibrosis Research Advances
  • Biosensors and Analytical Detection
  • Oral microbiology and periodontitis research
  • Microbial Community Ecology and Physiology
  • Antimicrobial Resistance in Staphylococcus

Universität Greifswald
2018-2021

Czech Academy of Sciences, Institute of Microbiology
2019

is the causative agent of various biofilm-associated infections in humans causing major healthcare problems worldwide. This type infection inherently difficult to treat because a reduced metabolic activity biofilm-embedded cells and protective nature surrounding extracellular matrix (ECM). However, little known about

10.1074/mcp.ra118.001120 article EN cc-by Molecular & Cellular Proteomics 2019-03-08

Microorganisms are predominantly organized in biofilms, where cells live dense communities and more resistant to external stresses than their planktonic counterparts. With vitro experiments, the susceptibility of Candida albicans biofilms a nonthermal plasma treatment (plasma source, kINPen09) terms growth, survival, cell viability was investigated. C. strain SC5314 (ATCC MYA-2876) treated for different time periods (30 s, 60 120 180 300 s). The results encompassing CFU, fluorescence...

10.1128/aem.01163-18 article EN Applied and Environmental Microbiology 2018-08-27

Summary The susceptibility of Candida albicans biofilms to a non‐thermal plasma treatment has been investigated in terms growth, survival and cell viability by series vitro experiments. For different time periods, the C. strain SC5314 was treated with microwave‐induced torch (MiniMIP). MiniMIP had strong effect (reduction factor (RF) = 2.97 after 50 s treatment) at distance 3 cm between nozzle superior regions biofilms. In addition, reduction 77% 20 metabolism 90% 40 were observed for ....

10.1111/1751-7915.13459 article EN cc-by Microbial Biotechnology 2019-07-01

Hallmarks of cystic fibrosis (CF) are increased viscosity mucus and impaired mucociliary clearance within the airways due to mutations conductance regulator gene. This facilitates colonization lung by microbial pathogens concomitant establishment chronic infections leading tissue damage, reduced function, decreased life expectancy. Although interplay between key CF plays a major role during disease progression, pathophysiology community in lungs remains poorly understood. Particular...

10.3389/fcimb.2021.724569 article EN cc-by Frontiers in Cellular and Infection Microbiology 2021-08-27

Abstract Microorganisms are predominantly organized in biofilms, where cells live dense communities and more resistant to external stresses compared their planktonic counterparts. With vitro experiments, the susceptibility of Candida albicans biofilms a non-thermal plasma treatment (plasma source kINP®09), terms growth, survival, cell viability was investigated. Behind that background, C. strain SC5314 (ATCC® MYA-2876™) treated for different time periods (30 s, 60 120 180 300 s). The results...

10.1101/323600 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2018-05-16
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