A5049903843- Estrogen and related hormone effects
- Healthcare Policy and Management
- Stress Responses and Cortisol
- Menopause: Health Impacts and Treatments
- Schizophrenia research and treatment
- Patient Satisfaction in Healthcare
- Neuroscience and Neuropharmacology Research
- Emergency and Acute Care Studies
- Memory and Neural Mechanisms
- demographic modeling and climate adaptation
- Neuroinflammation and Neurodegeneration Mechanisms
- Social and Intergroup Psychology
- Cancer, Stress, Anesthesia, and Immune Response
- Traumatic Brain Injury Research
- Psychology of Moral and Emotional Judgment
- Global Health Workforce Issues
- Health Systems, Economic Evaluations, Quality of Life
- Phosphodiesterase function and regulation
- Retinoids in leukemia and cellular processes
- Public Health in Brazil
- Evolutionary Psychology and Human Behavior
- Genomic variations and chromosomal abnormalities
- Adolescent and Pediatric Healthcare
- Medieval and Classical Philosophy
- Anesthesia and Neurotoxicity Research
RAND Corporation
2018-2019
University of Scranton
2016-2018
Geisinger Health System
2012-2014
Autism & Developmental Medicine Institute
2014
Yale University
2008-2013
Bucknell University
2012
Royal Victoria Hospital
2003
University of Ulster
2003
<h3>Context</h3>Research has implicated an addictive process in the development and maintenance of obesity. Although parallels neural functioning between obesity substance dependence have been found, to our knowledge, no studies examined correlates addictive-like eating behavior.<h3>Objective</h3>To test hypothesis that elevated“food addiction” scores are associated with similar patterns activation as dependence.<h3>Design</h3>Between-subjects functional magnetic resonance imaging...
The extracellular signal-regulated kinase (ERK) pathway is critical for various forms of learning and memory, activated by the potent estrogen 17β-estradiol (E 2 ). Here, we asked whether E modulates memory via ERK activation putative membrane-bound receptors (ERs). Using ovariectomized mice, first demonstrate that intraperitoneal injection 0.2 mg/kg significantly increases dorsal hippocampal levels phosphorylated protein 1 h after injection. Second, show administered intraperitoneally (0.2...
We previously demonstrated that dorsal hippocampal extracellular signal-regulated kinase (ERK) activation is necessary for 17β-estradiol (E 2 ) to enhance novel object recognition in young ovariectomized mice (Fernandez et al., 2008). Here, we asked whether E has similar memory-enhancing effects middle-aged and aged mice, these depend on ERK phosphatidylinositol 3-kinase (PI3K)/Akt activation. first intracerebroventricular or intrahippocampal infusion immediately after training enhanced...
The mammalian target of rapamycin (mTOR) signaling pathway is an important regulator protein synthesis and essential for various forms hippocampal memory. Here, we asked whether the enhancement object recognition memory consolidation produced by dorsal infusion 17β-estradiol (E 2 ) dependent on mTOR in hippocampus, E -induced phosphatidylinositol 3-kinase (PI3K) extracellular signal-regulated kinase (ERK) activation. We first demonstrated that induced was blocked inhibition ERK, PI3K, or...
This study examined the role of dorsal hippocampal NMDA receptors and PKA activation in 17βestradiol (E 2 )-induced enhancement object memory consolidation.Mice explored two identical objects during training, after which they immediately received intraperitoneal injections 0.2 mg/ kg E , bilateral infusions Vehicle, receptor antagonist APV (2.5 μg/side), or cAMP inhibitor Rp-cAMPS (18.0 μg/side).Retention was tested 48 hours later.The enhanced increased ERK phosphorylation observed with...
In this paper, we assess what neuroscience theory and method have contributed to the study of group processes intergroup relations see as potential future contributions discipline. We briefly review historical relation between social psychology, identify issues that may limit value relations, then argue indeed holds significant promise for understanding many key elements relations. Both problems benefits bridging psychology are considered in terms theoretical considerations, empirical...
This study examines the links between human perceptions, cognitive biases and neural processing of symmetrical stimuli. While preferences for symmetry have largely been examined in context disorders such as obsessive-compulsive disorder autism spectrum disorders, we examine various these phenomena non-clinical subjects suggest that are distributed throughout typical population part our architecture. In Experiment 1, 82 young adults reported on frequency their behaviors. Subjects also...
Aim Duration of untreated psychosis in early schizophrenia impacts long‐term outcomes. Because long‐acting injectable (LAI) antipsychotic drugs improve adherence early‐stage patients, they could reduce additional time uncontrolled (TUP) during the critical period illness. However, benefit LAI use over oral formulations has not been quantified. This study explores potential magnitude with a simulation approach. Methods A microsimulation models effects 11 treatment pathways reflecting...
The Centers for Medicare & Medicaid Services recently launched its Quality Payment Program (QPP), which changes how physicians are paid under Medicare. Significant concerns have been raised about the ability of small rural medical practices to successfully participate in QPP. RAND researchers interviewed on initial implementation QPP understand flexibility provisions and inform future federal rulemaking.
Abstract The impact of initiatives aimed at reducing time in untreated psychosis during early-stage schizophrenia will be unknown for many years. Thus, we simulate the effect earlier treatment entry and better antipsychotic drug adherence on schizophrenia-related hospitalizations, receipt disability benefits, competitive employment, independent/family living over a ten-year horizon. We predict that reduces hospitalizations by 12.6–14.4% benefit 7.0–8.5%, while increasing 41.5–46% employment...