A5002752313- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Pluripotent Stem Cells Research
- Protein purification and stability
- Animal Disease Management and Epidemiology
- Virology and Viral Diseases
- Epigenetics and DNA Methylation
- Renal and related cancers
- Viral Infectious Diseases and Gene Expression in Insects
- SARS-CoV-2 and COVID-19 Research
- Microfluidic and Bio-sensing Technologies
McGill University
2023-2024
Universidade de Ribeirão Preto
2020
Universidade de São Paulo
2016-2020
Abstract In the era of Biopharma 4.0, process digitalization fundamentally requires accurate and timely monitoring critical parameters (CPPs) quality attributes. Bioreactor systems are equipped with a variety sensors to ensure robustness product quality. However, during biphasic production viral vectors or replication‐competent viruses for gene cell therapies vaccination, current techniques relying on single working sensor can be affected by physiological state change cells due...
The administration of viral vectored vaccines remains one the most effective ways to respond ongoing novel coronavirus disease 2019 (COVID-19) pandemic. However, pre-existing immunity vector hinders its potency, resulting in a limited choice vectors. Moreover, basic batch mode manufacturing does not allow cost-effectively meet global demand for billions doses per year. To date, exposure humans VSV infection has been limited. Therefore, recombinant vesicular stomatitis virus (rVSV), which...
Newcastle disease (ND) remains a critical affecting poultry in sub-Saharan Africa. In some countries, repeated outbreaks have major impact on local economies and food security. Recently, we developed an adenovirus-vectored vaccine encoding the Fusion protein from Ethiopian isolate of virus (NDV). The adenoviral vector was designed, manufacturing process context Livestock Vaccine Innovation Fund initiative funded by International Development Research Centre (IDRC) Canada. industrially...
Sickle cell anemia (SCA) is a monogenic disease of high mortality, affecting millions people worldwide. There no broad, effective, and safe definitive treatment for SCA, so the palliative treatments are most used. The establishment an in vitro model allows better understanding how occurs, besides allowing development more effective tests treatments. In this context, iPSC technology powerful tool basic research modeling, promise finding screening drugs, possibility use regenerative medicine....
Newcastle Disease (ND) remains a critical disease affecting poultry in sub-Saharan Africa. In some countries, repeated outbreaks have major impact on local economies and food security. Recently, we developed an adenovirus-vectored vaccine encoding the Fusion protein from Ethiopian isolate of Virus (NDV). The adenoviral vector was designed manufacturing process context Livestock Vaccine Innovation Fund initia-tive funded by International Development Research Centre (IDRC) Canada....
Sickle cell disease (SCD) is a monogenic and it estimated that 300,000 infants are born annually with it. Most treatments available only palliative, whereas the allogeneic hematopoietic stem transplantation offers potential cure for SCD. Generation of human autologous cells, when coupled induced pluripotent (iPSC) technology, promising approach developing study models. In this study, we provide simple efficient model generating cells using iPSCs derived from sickle anemia patient an...