A5102893077- Axon Guidance and Neuronal Signaling
- Amyotrophic Lateral Sclerosis Research
- Neurogenesis and neuroplasticity mechanisms
- Hedgehog Signaling Pathway Studies
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Autophagy in Disease and Therapy
- Calpain Protease Function and Regulation
- Pharmacological Effects of Natural Compounds
- Ion channel regulation and function
- Organ Transplantation Techniques and Outcomes
- ATP Synthase and ATPases Research
- biodegradable polymer synthesis and properties
- Angiogenesis and VEGF in Cancer
- Muscle Physiology and Disorders
- Barrier Structure and Function Studies
- Herpesvirus Infections and Treatments
- Nerve injury and regeneration
- Fatty Acid Research and Health
- Anesthesia and Neurotoxicity Research
- Neurogenetic and Muscular Disorders Research
- Cardiac Ischemia and Reperfusion
- Genetic and Kidney Cyst Diseases
- Alcohol Consumption and Health Effects
First Affiliated Hospital of Xi'an Jiaotong University
2024
The University of Queensland
2021-2022
Beijing Ditan Hospital
2022
Capital Medical University
2022
The First Affiliated Hospital, Sun Yat-sen University
2014-2017
Sun Yat-sen University
2012-2017
Secondary impairment of blood-brain barrier (BBB) occurs in the remote thalamus after ischemic stroke. Netrin-1, an axonal guidance molecule, presents bifunctional effects on blood vessels through receptor-dependent pathways. This study investigates whether netrin-1 protects BBB against secondary injury. Netrin-1 (600 ng/d for 7 days) was intracerebroventricularly infused 24 h middle cerebral artery occlusion (MCAO) hypertensive rats. Neurological function assessed 8 and 14 days MCAO,...
Amyotrophic Lateral Sclerosis (ALS) is characterized by degeneration of motor neurons in the brain and spinal cord. Cytoplasmic inclusions TDP-43 are frequently reported ALS patients. has also been shown to associate with stress granules (SGs), a complex proteins mRNAs formed response stimuli that temporarily sequester mRNA translation. The effect pathogenic mutations within glycine-rich regions (where majority ALS-causing occur) on SG dynamics poorly understood. To address this issue, we...
Abstract A central event in the pathogenesis of motor neuron disease (MND) is loss neuromuscular junctions (NMJs), yet mechanisms that lead to this MND remain be fully elucidated. Maintenance NMJ relies upon neural agrin ( n -agrin) which, when released from nerve terminal, activates postsynaptic Muscle Specific Kinase (MuSK) signaling complex stabilize clusters acetylcholine receptors. Here, we report muscle patients has an increased proportion slow fibers and with smaller diameter. cells...
This study investigated the role of mitochondrial dynamics in postoperative cognitive dysfunction (POCD) and assessed therapeutic potential modulation, particularly through inhibition dynamin-related protein 1 (DRP1) with Mdivi-1. Our findings indicated that DRP1 substantially mitigated neuroinflammation mediated by microglial cells, contributing to improved function POCD models. The administration Mdivi-1 led a notable decrease fission, reduced reactive oxygen species (ROS) production,...
A clear association between diabetes and cognitive impairment has been demonstrated in past studies, increasing the incidence of neurodegenerative diseases accelerating onset Alzheimer's disease (AD) other types dementia. Many hypothesized mechanisms leading to exist, mechanism insulin resistance demonstrated. Transnasal administration improves recall spatial memory healthy subjects addition verbal working memory, visuospatial delayed performance cognitively impaired patients. No safety...
Objectives: Coronary endothelial dysfunction has been described as a potential side effect of brain death. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage. Protective effects α-1-antitrypsin (AAT), human neutrophil serine protease inhibitor, against IR have demonstrated. We hypothesized that physiological saline-supplemented AAT would protect brain-dead (BD) rats' vascular grafts from injury.