A5069342243- Adipose Tissue and Metabolism
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Cannabis and Cannabinoid Research
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Pain Mechanisms and Treatments
- Laser-induced spectroscopy and plasma
- Cellular Mechanics and Interactions
- Muscle metabolism and nutrition
- Metabolism, Diabetes, and Cancer
- Biochemical effects in animals
- Ion Channels and Receptors
- Bariatric Surgery and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Meat and Animal Product Quality
- Diabetes Treatment and Management
- Mollusks and Parasites Studies
- Osteoarthritis Treatment and Mechanisms
- Analytical chemistry methods development
- Cell Image Analysis Techniques
- Environmental Toxicology and Ecotoxicology
- Zebrafish Biomedical Research Applications
Dana-Farber Cancer Institute
2018-2021
Harvard University
2018-2021
University of Chicago
2020
Alvernia University
2017
Bowdoin College
2016
Significance Bioactive lipids control a wide variety of physiologic processes. We have recently identified branch bioactive lipid signaling mediated by N -acyl amino acids (NAAs) and the circulating enzyme peptidase M20 domain-containing 1 (PM20D1). Here we generate characterize mice globally deficient in PM20D1. These PM20D1-KO bidirectional changes NAA levels blood tissues exhibit metabolic nociceptive phenotypes. Our findings elucidate endogenous functions for vivo suggest PM20D1...
N-Acyl amino acids directly bind mitochondria and function as endogenous uncouplers of UCP1-independent respiration. We found that administration N-acyl to mice improves glucose homeostasis increases energy expenditure, indicating this pathway might be useful for treating obesity associated disorders. report the full account synthesis mitochondrial uncoupling bioactivity lipidated their unnatural analogues. Unsaturated fatty acid chains medium length neutral head groups are required optimal...
Vertebrate forelimbs contain arrays of sensory neuron fibers that transmit signals from the skin to nervous system. We used genetic toolkit and optical clarity larval zebrafish conduct a live imaging study neurons innervating pectoral fin skin. Sensory in both hindbrain spinal cord innervate fin, with most population located hindbrain. The somas are rhombomere seven/eight, laterally dorsally displaced motor pool. anterior part cord, aligned myomere four. Single cell reconstructions were map...
In this physical chemistry laboratory, the students develop experience in using Laser-Induced Breakdown Spectroscopy (LIBS) to analyze spectral emission data from determine lifetimes of neutral and singly-ionized titanium species LIBS plasmas. is a spectroscopic technique that focuses high power laser on surface. The heats, ablates, atomizes, ionizes surface material which creates plasma. light plasma then spectrally resolved detected. For experiments, can be collected gated (using time...