A5047985873- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Neurological Disorders and Treatments
- Mitochondrial Function and Pathology
- Fatty Acid Research and Health
- RNA modifications and cancer
- Congenital heart defects research
- Autism Spectrum Disorder Research
- Social Sciences and Governance
- Endoplasmic Reticulum Stress and Disease
- Neurological Disease Mechanisms and Treatments
- Alcoholism and Thiamine Deficiency
- Diet and metabolism studies
- Vagus Nerve Stimulation Research
- Biomedical Research and Pathophysiology
- Adenosine and Purinergic Signaling
- Retinoids in leukemia and cellular processes
- Regulation of Appetite and Obesity
German Institute of Human Nutrition
2018-2022
German Center for Diabetes Research
2018-2020
Heinrich Heine University Düsseldorf
2018-2020
Deutsches Diabetes-Zentrum e.V.
2018-2020
Centre National de la Recherche Scientifique
2019
Université de Lille
2011-2019
Centre Hospitalier Universitaire de Lille
2017-2019
Inserm
2011-2019
Université Côte d'Azur
2019
Institut de Pharmacologie Moléculaire et Cellulaire
2019
Alzheimer's disease is characterized by the combined presence of amyloid plaques and tau pathology, latter being correlated with progression clinical symptoms. Neuroinflammatory changes are thought to be major contributors pathophysiology, even if their precise role still remains largely debated. Notably, what extent immune responses contribute cognitive impairments promoted pathology poorly understood. To address this question, we took advantage THY-Tau22 mouse model that progressively...
The molecular pathways underlying tau pathology–induced synaptic/cognitive deficits and neurodegeneration are poorly understood. One prevalent hypothesis is that hyperphosphorylation, misfolding, fibrillization of impair synaptic plasticity cause degeneration. However, pathology may also result in the loss specific physiological functions, which largely unknown but could contribute to neuronal dysfunction. In present study, we uncovered a novel function its ability regulate brain insulin...
The τ pathology found in Alzheimer disease (AD) is crucial cognitive decline. Midlife development of obesity, a major risk factor insulin resistance and type 2 diabetes, increases the dementia AD later life. impact obesity on has been suggested to be related central resistance, secondary peripheral resistance. effects diet-induced (DIO) remain unknown. In this study, we evaluated high-fat diet, given at an early pathological stage, THY-Tau22 transgenic mouse model progressive AD-like...
While the spatiotemporal development of Tau pathology has been correlated with occurrence cognitive deficits in Alzheimer's patients, mechanisms underlying these remain unclear. Both brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor TrkB play a critical role hippocampus-dependent synaptic plasticity memory. When applied on hippocampal slices, BDNF is able to enhance AMPA receptor-dependent basal transmission through mechanism involving N-methyl-d-Aspartate receptors...
The Fragile X Mental Retardation Protein (FMRP) is a widely expressed RNA-binding protein involved in translation regulation. Since the absence of FMRP leads to Syndrome (FXS) and autism, has been extensively studied brain. functions peripheral organs on metabolic homeostasis remain elusive; therefore, we sought investigate systemic consequences its absence. Using metabolomics, vivo phenotyping Fmr1-KO FXS mouse model vitro approaches, show that induced shift towards enhanced glucose...
Overconsumption of high-fat and cholesterol-containing diets is detrimental for metabolism mitochondrial function, causes inflammatory responses impairs insulin action in peripheral tissues. Dietary fatty acids can enter the brain to mediate nutritional status, but also influence neuronal homeostasis. Yet, it unclear whether (HFDs) with different combinations exert metabolic stress impact function brain. To investigate cholesterol combination impacts C57BL/6J mice received either high...
Fragile X syndrome (FXS) is a neurodevelopmental disorder associated with intellectual disability, hyperactivity, and autism. FXS due to the silencing of X-linked FMR1 gene. Murine models FXS, knock-out (KO) for murine homolog Fmr1, have been generated, exhibiting CNS-related behavioral, neuronal anomalies reminiscent human phenotypes. As reflection almost ubiquitous expression gene, also accompanied by physical abnormalities. This suggests that FMR1-deficiency could impact skeletal...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular accumulation of amyloid deposits and intracellular neurofibrillary tangles (NFT) composed hyperphosphorylated Tau proteins. Brainderived neurotrophic factor (BDNF) playing critical role in hippocampal synaptic plasticity memory whose levels have been shown reduced AD brains. While recent data support pivotal β-amyloid peptides towards BDNF decrease, whether pathology impacts on expression remains unknown...
Brain insulin resistance represents a major health threat but its mechanisms remain still to be deciphered. We aim in this study identify novel molecular metabolites the cerebrospinal fluid (CSF) which associate with brain and test their effect on central signaling.
Tau proteins normally play an important role in microtubule polymerization and axonal transport. pathology results from the intracellular aggregation of hyperphosphorylated abnormally phosphorylated tau into filaments is encountered many neurodegenerative disorders known as tauopathies. In Alzheimer's disease (AD), leads to neurofibrillary degeneration (NFD), which appears first entorhinal cortex hippocampal formation then reaches isocortical areas. Several studies have outlined relationship...
Comment faire face à la crise en tant que chef d’entreprise ? La France a su développer une vraie pratique permettant d’accompagner les entreprises difficulté et leurs dirigeants. Afin de telles situations critiques, il est avant tout crucial savoir poser le bon diagnostic, grâce détection rapide des symptômes. Une fois cette étape passée, nécessaire d’identifier axes retournement négociations avec l’ensemble parties prenantes (entreprise, créanciers, État, salariés, etc.). Le contexte...