A5060221413- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Amyotrophic Lateral Sclerosis Research
- Barrier Structure and Function Studies
- Neurological diseases and metabolism
- Sphingolipid Metabolism and Signaling
- Cellular transport and secretion
- Nicotinic Acetylcholine Receptors Study
- Vascular Malformations Diagnosis and Treatment
Institut des Maladies Neurodégénératives
2015-2017
Centre National de la Recherche Scientifique
2015-2017
Inserm
2016-2017
Sorbonne Université
2016-2017
Institut du Cerveau
2016-2017
Université Paris Cité
2016
Université de Bordeaux
2015
Alzheimer's disease is characterized by the combined presence of amyloid plaques and tau pathology, latter being correlated with progression clinical symptoms. Neuroinflammatory changes are thought to be major contributors pathophysiology, even if their precise role still remains largely debated. Notably, what extent immune responses contribute cognitive impairments promoted pathology poorly understood. To address this question, we took advantage THY-Tau22 mouse model that progressively...
Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral hippocampus physiopathology, its behavior during Parkinson's disease remains undetected. In this study, we show an upregulation inducible nitric oxide synthase a downregulation 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced mouse model disease. Moreover, stimulation activity with vitamin...
Today a large number of studies are focused on clarifying the complexity and diversity pathogenetic mechanisms inducing Parkinson disease. We used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), neurotoxin that induces disease, to evaluate change midbrain structure behavior anti-inflammatory factor e-cadherin, interleukin-6, tyrosine hydroxylase, phosphatase tensin homolog, caveolin-1. The results showed strong expression variation length thickness heavy neurofilaments, increase...