Michel Degueldre

ORCID: 0000-0002-6034-0539
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About
Contact & Profiles
Research Areas
  • Reproductive Biology and Fertility
  • Reproductive Health and Technologies
  • Venomous Animal Envenomation and Studies
  • Uterine Myomas and Treatments
  • Minimally Invasive Surgical Techniques
  • Surgical Simulation and Training
  • Mass Spectrometry Techniques and Applications
  • Assisted Reproductive Technology and Twin Pregnancy
  • Endometrial and Cervical Cancer Treatments
  • Healthcare and Venom Research
  • Biochemical and Structural Characterization
  • Sperm and Testicular Function
  • Growth Hormone and Insulin-like Growth Factors
  • Ovarian function and disorders
  • Pelvic floor disorders treatments
  • Insect and Pesticide Research
  • Advanced Proteomics Techniques and Applications
  • Reproductive Health and Contraception
  • Anatomy and Medical Technology
  • Receptor Mechanisms and Signaling
  • Gynecological conditions and treatments
  • Nicotinic Acetylcholine Receptors Study
  • Anorectal Disease Treatments and Outcomes
  • Antimicrobial Peptides and Activities
  • Monoclonal and Polyclonal Antibodies Research

University of Liège
2012-2020

UCB Pharma (Belgium)
2019-2020

Centre Hospitalier Universitaire de Saint-Pierre
1988-2017

ORSI Academy
2017

Ghent University Hospital
2002

Hospital Garcia de Orta
1996

ZNA Middelheim Hospital
1996

Queen Elizabeth Hospital King's Lynn NHS Foundation Trust
1996

What is the effect of a legal limitation number embryos that can be transferred in an assisted reproductive technology (ART) cycle on multiple delivery rate?The Belgian national register shows introduction reimbursement ART laboratory costs July 2003, and imposition same year, were associated with >50% reduction pregnancy rate from 27 to 11% between 2003 last assessment 2010, without any per cycle.Individual IVF centres have published their results since implementation law, these show...

10.1093/humrep/det269 article EN Human Reproduction 2013-07-02

To set forth experiences in the context of SERGS Pilot Curriculum—the first standardized educational program for robotic use gynecological surgery—in terms feasibility, effectiveness and potential certification. The Society European Robotic Gynecological Surgery (SERGS) outlined a Curriculum education robot-assisted laparoscopic surgery. Its feasibility acceptance were checked form fellowship pilot conducted at four Centers Excellence Results conclusions derived from this are presented....

10.1007/s00404-017-4612-5 article EN cc-by Archives of Gynecology and Obstetrics 2017-12-13

Background: Tityus serrulatus venom (Ts venom) is a complex mixture of several compounds with biotechnological and therapeutical potentials, which highlights the importance identification characterization these components. Although considerable number studies have been dedicated to this cocktail, there still limitation knowledge concerning its composition. Most Ts aim isolate characterize their neurotoxins, are small, basic proteins eluted high buffer concentrations on cation exchange...

10.1590/1678-9199-jvatitd-1482-18 article EN cc-by ˜The œJournal of venomous animals and toxins including tropical diseases 2019-01-01

Four-hundred-and-ninety-one oocytes were collected from 142 successive patients attending for in-vitro fertilization. The systematic observation of pronuclei between 14 and 18 h after insemination revealed 27 cases tripronucleate eggs among 391 fertilized (6.9%), which corresponds to rates generally reported in the literature. following parameters analysed relation incidence these eggs: aetiology infertility, follicular response hormonal stimulation, type ovulatory stimulus, sperm count...

10.1093/oxfordjournals.humrep.a136354 article EN Human Reproduction 1986-02-01

FIGO classification is commonly used for staging of locally advanced cervical cancer. Laparoscopic para-aortic lymphadenectomy currently as a diagnostic tool, since we know that presence lymph node metastases identifies patients with poor prognosis. The application robotics during this procedure needs to be investigated.Retrospective multi-center study.Three centers participated in building one database.Thirty-seven cancer underwent robot-assisted laparoscopic lymphadenectomy.Patients were...

10.1111/aogs.12150 article EN Acta Obstetricia Et Gynecologica Scandinavica 2013-04-16

Journal Article Early pregnancy loss and obstetrical risk after in-vitro fertilization embryo replacement Get access P. Barlow, Barlow IVF Clinic, St Pierre Hospital, Free University of Brussels322 rue Haute, 1000 Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Lejeune, Lejeune F. Puissant, Puissant Y. Englert, Englert M. Van Rysselberge, Rysselberge Degueldre, Degueldre Vekemans, Vekemans Leroy Human Reproduction, Volume 3, Issue 5, 1 July 1988,...

10.1093/oxfordjournals.humrep.a136765 article EN Human Reproduction 1988-07-01

Disulfide bonds are post-translationnal modifications that can be crucial for the stability and biological activities of natural peptides. Considering importance these disulfide bond-containing peptides, development new techniques in order to characterize is great interest. For this purpose, collision cross cections (CCS) a large data set 118 peptides (displaying various sequences) bearing zero, one, two, or three bond(s) have been measured study at different charge states using ion...

10.1007/s13361-016-1443-8 article EN Journal of the American Society for Mass Spectrometry 2016-08-03

Animal venoms are rich in hundreds of toxins with extraordinary biological activities. Their exploitation is difficult due to their complexity and the small quantities venom available from most venomous species. We developed a Venomics approach combining transcriptomic proteomic characterization 191 species identified 20,206 toxin sequences. Two complementary production strategies based on solid-phase synthesis recombinant expression Escherichia coli generated physical bank 3597 toxins....

10.1021/acs.jmedchem.0c00485 article EN Journal of Medicinal Chemistry 2020-06-30

Two hundred and forty-seven patients with uterine fibroids were randomized to surgery alone or 3 months' Zoladex® (Zeneca, Macclesfield, Ches., UK) followed by surgery. Zoladex significantly reduced fibroid volumes (p = 0.0001). There was a 0.002) greater mean rise in haemoglobin from entry preoperation the group (1 g/dl) compared surgery-alone (0.3 as well tendency towards easier surgery, operative blood loss. Zoladex-treated had 0.016) shorter hospital stay pelvic pain abdominal pressure...

10.1159/000184806 article EN Hormone Research 1996-01-01

Confocal laser endomicroscopy (CLE) enables in-vivo, real-time, imaging of tissues with a micron-scale resolution through fiber optic probe. CLE could be valuable tool for the detection and characterization suspicious (dysplastic) areas on uterine cervix in minimally invasive manner. This study evaluates technical feasibility safety cervix. The also aims to create preliminary iconography normal dysplastic squamous columnar cervical epithelium. In-vivo was performed nine patients scheduled...

10.1097/cej.0000000000000188 article EN European Journal of Cancer Prevention 2015-08-19

(2002). Return to fertility in nulliparous and parous women after removal of the GyneFix® intrauterine contraceptive system. The European Journal Contraception & Reproductive Health Care: Vol. 7, No. 1, pp. 24-30.

10.1080/ejc.7.1.24.30 article EN The European Journal of Contraception & Reproductive Health Care 2002-01-01

Animal venoms represent a valuable source of bioactive peptides that can be derived into useful pharmacological tools, or even innovative drugs. In this way, the venom Dendroaspis angusticeps (DA), Eastern Green Mamba, has been intensively studied during recent years. It mainly contains hundreds large toxins from 6 to 9 kDa, each displaying several disulfide bridges. These are main target venom-based studies due their activities obtained by selectively targeting membrane receptors, such as...

10.3390/ijms18112453 article EN International Journal of Molecular Sciences 2017-11-18
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