A5049550873- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Pneumocystis jirovecii pneumonia detection and treatment
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- Clostridium difficile and Clostridium perfringens research
- Healthcare Policy and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
St. Antonius Ziekenhuis
2018-2025
Leiden University
2021-2022
Background Adjunctive intravenous corticosteroid treatment has been shown to reduce length of stay (LOS) in adults hospitalised with community-acquired pneumonia (CAP). We aimed assess the effect oral dexamethasone on LOS and whether this is disease severity dependent. Methods In multicentre, stratified randomised, double-blind, placebo-controlled trial, immunocompetent CAP were randomly assigned (1:1 ratio) receive (6 mg once daily) or placebo for 4 days four teaching hospitals Netherlands....
Latent class analysis (LCA) has identified subgroups with meaningful treatment implications in acute respiratory distress syndrome. We performed a secondary of three studies to assess whether LCA can identify clinically distinct community-acquired pneumonia (CAP) and the effect adjunctive corticosteroids differs between subgroups.LCA was on baseline clinical biomarker data from Ovidius trial (n=304) Steroids Pneumonia (STEP) (n=727), both randomised controlled trials investigating...
Utilization of diagnostics and biomarkers are the second largest cost drivers in management patients hospitalized with community-acquired pneumonia (CAP). The present study aimed to systematically assess inter-hospital variation these relation antibiotic use CAP. Detailed resource utilization data from 300 who participated a multicenter placebo-controlled trial investigating dexamethasone as adjunctive treatment for was grouped into 3 categories: clinical chemistry testing, radiological...
Abstract Background Corticosteroids could improve outcomes in patients with community-acquired pneumonia (CAP). However, we hypothesize that corticosteroid effectiveness varies among individual patients, resulting inconsistent and unclear clinical indication. Therefore, developed validated a predictive, causal model based on baseline characteristics to predict individualized treatment effects (ITEs) of corticosteroids mortality CAP. Methods We obtained patient data from six randomized...
Latent class analysis (LCA), a statistical method to identify ‘hidden’ subgroups within population, has identified clinically distinct with treatment implications in acute respiratory distress syndrome and COVID-19 [1–3]. We recently showed that LCA could also two community-acquired pneumonia (CAP) [4]. In independent cohorts [5, 6], subgroup more excessive systemic inflammation worse prognosis (Class 2), less better 1). one of the cohorts, Ovidius cohort, we observed greater effect...
<b>Background:</b> It is unclear whether the extent of microbiological testing associated with antibiotic de-escalation in adults hospitalised community-acquired pneumonia (CAP). <b>Aims and Objectives:</b> To explore this relationship. <b>Methods:</b> We retrospectively studied 283 immunocompetent patients CAP. Patients were grouped according to number different tests performed within first two days admission (0-5 tests). De-escalation rates compared between these groups. Antimicrobial was...
<b>Background:</b> Adjunctive intravenous corticosteroid treatment has shown to reduce length of stay (LOS) in adults hospitalised with community-acquired pneumonia (CAP). However, the effect oral dexamethasone on LOS and whether this is disease severity dependent remains unclear. <b>Aims & objectives:</b> We aimed assess dependent. <b>Methods:</b> In multicentre, stratified randomised, double-blind, placebo-controlled trial, CAP were randomly assigned (1:1 ratio) receive (6 mg once...