A5089899014- Neurological diseases and metabolism
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Microbial Metabolism and Applications
- Vector-borne infectious diseases
- Plant Virus Research Studies
- Mosquito-borne diseases and control
- Microbial Natural Products and Biosynthesis
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- RNA regulation and disease
- Porphyrin Metabolism and Disorders
- Biochemical and Molecular Research
Yale University
2021-2024
Babesiosis is a malaria-like disease in humans and animals that caused by Babesia species, which are tick-transmitted apicomplexan pathogens. duncani causes severe to lethal infection humans, but despite the risk this parasite poses as an emerging pathogen, little known about its biology, metabolic requirements or pathogenesis. Unlike other parasites infect red blood cells, B. can be continuously cultured vitro human erythrocytes mice resulting fulminant babesiosis death. We report...
Abstract Key Points Using an antigen capture assay to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike S1 protein, we found that the protein is present in urine of 25% patients with disease 2019 (COVID-19). Further, 24% and 21% adult COVID-19 have high levels albumin cystatin C, respectively. The presence SARS-CoV-2 suggests renal abnormalities resulting from COVID-19. Background infection has, as April 2021, affected >133 million people worldwide, causing >2.5...
Summary Fungal infections, a leading cause of mortality among eukaryotic pathogens, pose growing global health threat due to the rise drug-resistant strains. New therapeutic strategies are urgently needed combat this challenge. The PCA pathway for biosynthesis Co-enzyme A (CoA) and Acetyl-CoA (AcCoA) from vitamin B5 (pantothenic acid) has been validated as an excellent target development new antimicrobials against fungi protozoa. regulates key cellular processes including metabolism fatty...
ABSTRACT SARS-CoV-2 infection has so far affected over 42 million people worldwide, causing 1.1 deaths. With the large majority of infected individuals being asymptomatic, major concerns have been raised about possible long-term consequences infection. We developed an antigen capture assay to detect spike protein in urine samples from COVID-19 patients whose diagnosis was confirmed by PCR nasopharyngeal swabs (NP-PCR+). The study used a collection 233 132 participants Yale New Haven Hospital...
SUMMARY Fungal infections, a leading cause of mortality among eukaryotic pathogens, pose growing global health threat due to the rise drug-resistant strains. New therapeutic strategies are urgently needed combat this challenge. The PCA pathway for biosynthesis Co-enzyme A (CoA) and Acetyl-CoA (AcCoA) from vitamin B5 (pantothenic acid) has been validated as an excellent target development new antimicrobials against fungi protozoa. regulates key cellular processes including metabolism fatty...
Abstract Babesia species are tick-transmitted apicomplexan pathogens and the causative agents of babesiosis, a malaria-like disease major medical veterinary importance. Of different reported so far, duncani causes severe to lethal infection in patients. Despite highly virulent nature this parasite risk it may pose as an emerging pathogen, little is known about its biology, metabolic requirements, pathogenesis. B. unique among parasites that infect red blood cells can be continuously cultured...