A5064621938- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Lung Cancer Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Brain Metastases and Treatment
- Protein purification and stability
- Epigenetics and DNA Methylation
- Multiple and Secondary Primary Cancers
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Viral Infectious Diseases and Gene Expression in Insects
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
Huashan Hospital
2015-2024
Fudan University
2015-2024
Medullary breast carcinoma is a rare with good prognosis. Although it has been established that axillary lymph node metastasis poor prognostic factor, little known about the relationship between and clinicopathological characteristics of medullary patients. The aim this study was to identify factors predict occurrence in We performed retrospective status relevant 49 triple-negative patients dissection November 2004 July 2011. A total were enrolled study. Fourteen (28.6%) had confirmed...
An increase in the detection rate of multiple primary cancers has been accompanied with declining cancer death rates over past few decades. However, synchronous tumors have gradually increased, and molecular mechanisms involved occurrence different origins are unclear. To investigate these mechanisms, we sequenced tissues by FoundationOne CDx. Data were annotated annovar , then performed pathway enrichment analysis. A total 109 genes that mutated all samples clustered into diseases,...
Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate iso-aspartate residues. Moreover, Asu plays an important role protein degradation pathways, deamidation, aspartic acid isomerization. Here, modification with a high abundance framework region (FR) of golimumab was first reported, effect denaturing buffer pH on homeostasis studied, results revealed that relatively stable over range 6.0-7.0 whereas rapid...
Abstract Background Lung cancer stands as the second most prevalent malignant neoplasm worldwide. Addressing underlying mechanisms propelling progression of non-small cell lung is paramount importance. In this study, we have elucidated pivotal role PHF12 in context. Materials and methods We harnessed clinical tissue samples lines to discern expression pattern PHF12. vitro assays probing proliferation were conducted substantiate functional impact Furthermore, an vivo Xenograft model was...
(1) Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been the first line therapy for EGFR-mutant lung adenocarcinoma (LAC) patients with brain metastases (BMs). However, role and optimal time of radiotherapy remains controversial. We aimed to investigate upfront stereotactic (SRS) impact deferral on patients’ clinical outcomes. (2) Methods: retrospectively studied 53 LAC limited synchronous BMs between 2014 2020 at our institute. The was defined one...
Although numerous measures have been used to improve the outcome of lung cancer patients, cancer, as second most common diagnosed is still main cause death. It becomes increasingly urgent for us deeply deplore molecular mechanism and discover potential therapeutic targets. In our study, we are dedicated discovering role MIB2 in development. The public databases were compare expression level non-cancer tissue. We analyzed samples by performing Rt-PCR western blot. carried out CCK8 clone...
Abstract Background: Lung cancer stands as the second most prevalent malignant neoplasm worldwide. Addressing underlying mechanisms propelling progression of non-small cell lung is paramount importance. In this study, we have elucidated pivotal role PHF12 in context. Materials and Methods: We harnessed clinical tissue samples lines to discern expression pattern PHF12. vitro assays probing proliferation were conducted substantiate functional impact Furthermore, an vivo Xenograft model was...
Driver gene-positive non-small cell lung cancer (NSCLC) patients are prone to develop leptomeningeal metastasis (LM), leading an extremely high mortality. The objective of this study was assess the efficacy and safety immune checkpoint inhibitors (ICIs) treatments for with NSCLC LM harboring targetable mutations.
Background: Although numerous measures have been used to improve the outcome of lung cancer patients, cancer, as second most common diagnosed is still main cause death. It becomes increasingly urgent for us deeply deplore molecular mechanism and discover potential therapeutic targets. In our study, we are dedicated discovering role MIB2 in development.Methods: The public databases were compare expression level non-cancer tissue. We analyzed samples by performing Rt-PCR western blot. carried...