1. We have investigated the receptors mediating endothelin-induced contraction of rabbit isolated jugular vein (RJV) and rat thoracic aorta (RTA). 2. Endothelin-1 (ET-1) endothelin-3 (ET-3) contracted RJV preparations with similar potency (EC50 values approximately 1 nM), whereas, ET-1 (EC50:4.5 nM) was 80 fold more potent than ET-3 in contracting RTA. In addition, ETB receptor-selective agonist [Ala1,3,11,15]ET-1 (EC50:2.1 but not 3. The ETA receptor antagonist, BQ123, competitively...

Journal Article Cyclosporin for severe childhood atopic dermatitis: short course versuscontinuous therapy Get access J.I. Harper, Harper Department of Paediatric Dermatology, Great Ormond Street Hospital Children, London WC1N 3JH, U.K. J.I.Harper. Search other works by this author on: Oxford Academic Google Scholar I. Ahmed, Ahmed Walsgrave Hospital, Coventry CV2 2DX, G. Barclay, Barclay M. Lacour, Lacour P. Hoeger, Hoeger M.J. Cork, Cork Molecular and Genetic Medicine, Royal Hallamshire...

Abstract This was an open‐label, prospective, multicentre, randomised controlled study to evaluate the efficacy and safety of human fibroblast‐derived dermal substitute ( HFDS ) plus four‐layer compression therapy compared with alone in treatment venous leg ulcers. The primary outcome variable proportion patients completely healed ulcers by 12 weeks. number further summarised ulcer duration baseline size. Sixty‐four (34%) 186 group experienced healing week 56 (31%) 180 control P = 0·235)....

This study has explored the mechanism underlying long duration of action β 2 ‐adrenoceptor agonist, salmeterol. Salmeterol, salbutamol and isoprenaline caused a concentration‐related inhibition electrically‐induced contractile responses guinea‐pig superfused trachea preparation. The effects both were rapid in onset rapidly reversed upon removal agonist. In contrast, salmeterol slower could not be by superfusion tissue with agonist‐free Krebs solution even for periods up to 10 h. were,...

Bolus infusion (BI) recombinant factor VIIa (rFVIIa) administration is safe and effective in the surgical management of haemophilia patients with inhibitors but has not been compared directly continuous (CI). We conducted an open-label, randomized, multicenter trial comparing efficacy safety rFVIIa administered by BI or CI for A B to FVIII FIX. Safety was that a control group non-inhibitor receiving FIX concentrates major surgery. All inhibitor subjects received initial bolus dose 90...

We have examined the binding of 5-carboxamidotryptamine (5-CT) and GR43175 (3-(2-dimethylamino)ethyl-N-methyl-1H-indole-5-methane sulphonamide) to 5-HT1D sites labelled with [3H]-5-hydroxytryptamine [( 3H]-5-HT) in neonatal porcine caudate membranes. In competition studies, 5-CT produced shallow inhibition curves (Ki 138 nM, slope 0.31), indicating site heterogeneity, while interacted a single population 251 0.98), producing maximum only 52% [3H]-5-HT compared 100% for 5-HT or 5-CT. presence...

5‐Hydroxytryptamine (5‐HT) and 5‐carboxamidotryptamine (5‐CT) produce both smooth muscle relaxation elevation of tissue adenosine 3′: 5′‐cyclic monophosphate (cyclic AMP) levels in isolated rings neonatal porcine vena cava. We now present studies attempting to characterize more detail the 5‐HT receptor mediating these responses. Both 5‐CT relaxed cava (EC 50 values 200 n m 4 respectively) elevated cyclic AMP 1500 16 respectively). For responses was approximately 50–100 fold potent than 5‐HT....

Endothelin (ET) ETA receptors on vascular smooth muscle are believed to mediate the vasoconstrictor effects of ET isopeptides, and ETB endothelium thought vasodilator effects. This study has investigated mediating endothelin-induced contraction isolated ring preparations rat thoracic aorta (RTA) rabbit carotid artery (RCA), pulmonary (RPA), jugular vein (RJV). In RTA RCA, ET-1 (EC50 4.5 5.2 nM, respectively) was 82- 108-fold, respectively, more potent than ET-3, whereas receptor-selective...

The development of mucilage in the epidermal cells canola seeds (Brassica campestris L. cv. Candle) was studied with light and electron microscopy from 5 days after pollination to maturity. During first 17 starch deposited amyloplasts. At or near 17th day appeared between plasmalemma outer tangential wall cells. As volume increased, grains disappeared were totally absent by 25 days. Membrane-bound structures Golgi bodies visible within cytoplasm adjacent site deposition. maturity seed devoid...

1. 5-Hydroxytryptamine (5-HT) relaxes rings of neonatal porcine isolated vena cava by both an endothelium-dependent and endothelium-independent mechanism. The receptor mediating the latter response has been shown to be a 5-HT1-like (positively coupled adenylyl cyclase) located on vascular smooth muscle. features 5-HT in this preparation are now described. 2. In ring preparations contracted with stable thromboxane-A2-mimetic, U-46619 (10 nM), presence 5-HT2 antagonist ketanserin (1 microM),...

Summary. This study sought to identify attributes of treatment important haematologists in making their decisions regarding optimal care for inhibitor patients the United States. A conjoint analysis using a discrete choice experiment was conducted elicit factors that are most haematologists. Twelve product were chosen based on published literature and expert opinion: risk human viral infections, possibility titre may rise, reduction likelihood dose‐related thromboembolic events, number...

<h2>Abstract</h2><h3>Purpose</h3> Sublingual buprenorphine and combination buprenorphine/naloxone (BNX) are effective options for the treatment of opioid dependence. A BNX sublingual tablet approved by US Food Drug Administration induction maintenance opioid-dependence in adults was developed as a higher-bioavailability formulation, allowing 30% lesser dose with bioequivalent systemic exposure compared another formulation. No data were previously available comparing to generic or film; we...

In an effort to reduce medication discrepancies during transitions of care and improve accuracy the patient's list, AU Health conducted a study identify comprehensive set issues related electronic health record (EHR) reconciliation (MedRec) from perspective practitioners directly involved in EHR MedRec process.An exploratory mixed-method design was used. The 2-round included 15 individual interviews, followed by survey 200 (ie, physicians, nurses, pharmacists) based outpatient inpatient...

We have investigated the mechanism of smooth muscle contraction evoked by activation 5‐HT 1 ‐like receptors in dog isolated saphenous vein. In presence 2 receptor antagonist, ritanserin (0.1 μ m ), concentration‐effect curves (10 n ‐300 ) for 5‐hydroxytryptamine (5‐HT)‐induced were biphasic. This could be attributed to a direct action on at low concentrations ‐10 and an indirect (through release noradrenaline from sympathetic neurones) postjunctional α‐adrenoceptors higher concentrations....

(1998). The role of lignification as a resistance mechanism in wheat to toxin-producing isolate Pyrenophora tritici-repentis. Canadian Journal Plant Pathology: Vol. 20, No. 1, pp. 35-47.

The egg apparatus of Brassica campestris L. cv. Candle (canola-rapeseed) is composed an and two synergids juxtaposed at the extreme micropylar end megagametophyte with cell displaced in a chalazal direction. walls are uniformly PAS PA–TCH–SP-positive, but contained β-linked glucans only region. number development cytoplasmic organelles suggested that relatively inactive metabolically while synergid cells active. contain large numbers dictyosomes PA–TCH–SP-positive vesicles maturing face....

The aim of the study was to evaluate treatment retention, efficacy, and preference ratings among opioid-dependent patients transitioning between a buprenorphine/naloxone rapidly dissolving sublingual tablet formulation (BNX-RDT) BNX film.

This prospective, randomized, active-controlled, non-inferiority study evaluated the efficacy and safety of a sublingual buprenorphine/naloxone rapidly dissolving tablet (Zubsolv®; tablet) versus generic buprenorphine for induction opioid maintenance among dependent adults. The study, conducted at 13 sites from June 2013 to January 2014, included 2-day blinded phase 27-day open-label stabilization/maintenance phase. During induction, patients received fixed doses tablets or buprenorphine....

A 1 year, prospective multicentre study was performed to investigate the efficacy and safety of intermittent treatment with cyclosporin in psoriasis vulgaris. Subjects received (Neoral(r)) 5mg/kg per day until achieving 90% reduction area affected, or for a maximum 12 weeks. Those failing demonstrate satisfactory response were withdrawn. When further required, recommenced. This cycle repeated up three times. Psoriasis activity recorded using affected sign scores erythema, scaling...