A5007666488- Vascular Malformations and Hemangiomas
- Dermatology and Skin Diseases
- Tumors and Oncological Cases
- Neonatal skin health care
- Skin and Cellular Biology Research
- Vascular Malformations Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Histiocytic Disorders and Treatments
- Vascular Tumors and Angiosarcomas
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Erythrocyte Function and Pathophysiology
- Autoimmune and Inflammatory Disorders Research
- Fungal Infections and Studies
- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Teratomas and Epidermoid Cysts
- Psoriasis: Treatment and Pathogenesis
- Urologic and reproductive health conditions
- Medicine and Dermatology Studies History
- Advancements in Transdermal Drug Delivery
Katholisches Kinderkrankenhaus Wilhelmstift
2016-2025
Universität Hamburg
2002-2024
Kinderkrebs-Zentrum Hamburg
1995-2019
Boston Children's Hospital
1994-2015
Charité - Universitätsmedizin Berlin
2009
Helios Klinikum Emil von Behring
2009
University College London
1998-2004
Great Ormond Street Hospital
1998-2004
University Medical Center Hamburg-Eppendorf
2001-2003
Freie Universität Berlin
2000
Oral propranolol has been used to treat complicated infantile hemangiomas, although data from randomized, controlled trials inform its use are limited.
BackgroundSafe and effective therapies are needed for pediatric patients with psoriasis.ObjectiveThe purpose of this study was to evaluate ustekinumab in age 12 17 years who had moderate-to-severe psoriasis.MethodsPatients (n = 110) were randomly assigned standard dosing (SD; 0.75 mg/kg [≤60 kg], 45 mg [>60-≤100 90 [>100 kg]) or half-standard (HSD; 0.375 22.5 at weeks 0 4 every placebo crossover SD HSD week 12. Clinical assessments included the proportion achieving a Physician's Global...
Journal Article Cyclosporin for severe childhood atopic dermatitis: short course versuscontinuous therapy Get access J.I. Harper, Harper Department of Paediatric Dermatology, Great Ormond Street Hospital Children, London WC1N 3JH, U.K. J.I.Harper. Search other works by this author on: Oxford Academic Google Scholar I. Ahmed, Ahmed Walsgrave Hospital, Coventry CV2 2DX, G. Barclay, Barclay M. Lacour, Lacour P. Hoeger, Hoeger M.J. Cork, Cork Molecular and Genetic Medicine, Royal Hallamshire...
Although neonatal and adult epidermis are similar with respect to thickness lipid composition, skin development is not complete at birth. Previous studies indicate that the undergoes a process of adaptation maturation postnatally. Postnatal physiology has yet been evaluated comprehensively in prospective study. We assessed function parameters prospectively cohort 202 healthy term neonates (98 boys) Caucasian descent. Measurements were performed 3 days, 4 weeks, 12 weeks age four different...
Staphylococcal skin colonization is a common feature of atopic dermatitis (AD) in adults. Little known about prevalence and persistence staphylococci children. Forty-one AD children (mean age, 70 months) 41 age-matched controls were studied. S. aureus was isolated from 38 patients (93%;32% controls, P < .001) 37% ofAD (5% harbored toxigenic (enterotoxins, toxic shock syndrome toxin) strains. No individual biotype prevailed. On follow-up interval, 9 months), 70% strains reisolated. Nasal...
Oral propranolol is widely prescribed as first-line treatment for infantile haemangiomas (IHs). Anecdotally, prescribing practice differs between centres.The Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce was founded to establish patterns use in IHs.Participating centres entered data on all their patients who had completed with oral IHs, using an online capture tool.The study cohort comprised 1097 children from 39 eight European countries. 76·1% were female and...
Epidermolysis bullosa (EB) is a rare genetic disorder manifesting with skin and mucosal membrane blistering in different degrees of severity.Epidemiological data from countries have been published, but none are available Germany.In this population-based cross-sectional study, people living EB Germany were identified using the following sources: academic hospitals, diagnostic laboratories patient organization.Our study indicates an overall incidence 45 per million live births Germany. With...
We have previously reported that loss-of-function mutations in the cathepsin C gene (CTSC) result Papillon-Lefèvre syndrome, an autosomal recessive condition characterized by palmoplantar keratosis and early-onset, severe periodontitis. Others also CTSC patients with prepubertal periodontitis, but without any skin manifestations. The possible role of variants more common types non-mendelian, periodontitis ("aggressive periodontitis") has not been investigated. In this study, we investigated...
We report a 2-year-old boy with an unusual autosomal recessively inherited skin disease comprising trauma-induced fragility and congenital ectodermal dysplasia affecting hair, nails sweat glands. Skin biopsy showed widening of intercellular spaces between keratinocytes ultrastructural findings small, poorly formed desmosomes reduced connections to the keratin filament cytoskeleton. Immunohistochemical analysis revealed complete absence staining for accessory desmosomal plaque protein...
Journal Article Epidermal barrier lipids in human vernix caseosa: corresponding ceramide pattern and fetal skin Get access P.H. Hoeger, Hoeger Departments of Dermatology Dr Peter H.Hoeger. E‐mail: hoeger@uke.uni‐hamburg.de Search for other works by this author on: Oxford Academic Google Scholar V. Schreiner, Schreiner Paul‐Gerson‐Unna Skin Research Center, Beiersdorf Inc., Hamburg, Germany I.A. Klaassen, Klaassen C.C. Enzmann, Enzmann K. Friedrichs, Friedrichs Obstetrics/Gynaecology,...
Summary Background: Psoriasis, an inflammatory disorder of the skin, can significantly impact on a patient's quality life, affecting their daily activities and families. The onset psoriasis in childhood is quite common; however, treatment moderate‐to‐severe disease this population challenging, with paucity data reported few licensed agents available. Methods: A Delphi survey was conducted among panel European expert dermatologists physicians particular interest pediatric disorders. covered...
Adalimumab (ADA) (Humira® , AbbVie Inc., U.S.A.) is approved by the European Medicines Agency for children aged ≥ 4 years with severe plaque psoriasis.To evaluate long-term efficacy and safety of ADA in psoriasis.Results are presented from 52-week extension (LTE) randomized, double-blind, double-dummy, phase III trial, psoriasis (results prior periods have been published). Patients < 18 were randomized 1 : to 0·8 mg kg-1 (40 maximum) or 0·4 (20 every other week methotrexate (MTX) 0·1-0·4 (25...
Abstract Deoxyspergualin (DSG) is a novel immunosuppressive agent recently shown to bind the constitutive heat shock protein 70, which involved in binding and intracellular transport of antigenic peptides. In this study, we show that DSG inhibits proliferation PBMCs Ags tetanus toxoid diphtheria toxoid, but not mitogens PHA PMA/ionomycin, nor superantigens toxic syndrome toxin-1 staphylococcal enterotoxin A. DSG's effect was specific for monocytes as preincubation T cells with did inhibit...