A5024164941- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Oral and gingival health research
- Temporomandibular Joint Disorders
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Periodontal Regeneration and Treatments
- dental development and anomalies
- Tumors and Oncological Cases
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- RNA modifications and cancer
- Bone and Dental Protein Studies
- Laser Applications in Dentistry and Medicine
- Dental Implant Techniques and Outcomes
- Oral health in cancer treatment
- Connective tissue disorders research
- Cancer-related Molecular Pathways
- Bone health and treatments
- Cancer-related gene regulation
Newcastle upon Tyne Hospitals NHS Foundation Trust
2015-2025
Newcastle University
2015-2025
Newcastle upon Tyne Hospital
1984-2024
University Dental Hospital of Manchester
1997-2023
Royal Victoria Infirmary
2010-2023
Engineering and Physical Sciences Research Council
2016-2020
Queen Elizabeth II Health Sciences Centre
2018
Emory University
2018
Dalhousie University
2018
Cleveland Clinic
2018
Abstract Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression clustered with the 10 well-known hypoxia-regulated (e.g., CA9, GLUT1, VEGF). To minimize random aggregation, strongly correlated up-regulated appearing >50% clusters defined a signature comprising 99 genes, which 27% previously known be associated. The median RNA an independent prognostic factor for...
Abstract Purpose: Human papillomavirus-16 (HPV16) is the causative agent in a biologically distinct subset of oropharyngeal squamous cell carcinoma (OPSCC) with highly favorable prognosis. In clinical trials, HPV16 status an essential inclusion or stratification parameter, highlighting importance accurate testing. Experimental Design: Fixed and fresh-frozen tissue from 108 OPSCC cases were subject to eight possible assay/assay combinations: p16 immunohistochemistry (p16 IHC); situ...
Inhibition of monocarboxylate transporter (MCT) 1-mediated lactate transport may have cytostatic and/or cytotoxic effects on tumor cells. We report results from the dose-escalation part a first-in-human trial AZD3965, first-in-class MCT1 inhibitor, in advanced cancer.
Human papillomavirus (HPV) testing in oropharyngeal squamous cell carcinoma (OPSCC) is now advocated. Demonstration of transcriptionally active high-risk HPV (HR-HPV) fresh tumour tissue considered to be the analytical 'gold standard'. Clinical has focused on formalin-fixed paraffin-embedded (FFPE) at expense sensitivity and specificity. Recently, a novel RNA situ hybridisation test (RNAscope) been developed for detection HR-HPV FFPE tissue; however, validation against standard' not...
Oncogenic human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC) is a subtype of head-and-neck cancer with distinct clinical and prognostic profile. While there are calls to undertake HPV testing for SCCs within the diagnostic setting trials, currently no internationally accepted standards.142 tonsil were tested using p16 immunohistochemistry (IHC), high-risk DNA in situ hybridisation (ISH) polymerase chain reaction (PCR; GP5+/6+ primers).There high levels...
Abstract This is the official guideline endorsed by specialty associations involved in care of head and neck cancer patients UK. There has been significant debate management oropharyngeal last decade, especially light increased incidence, clarity on role human papilloma virus this disease treatment responsiveness positive cancers. paper discusses evidence base pertaining to provides recommendations for group receiving care. Recommendations • Cross-sectional imaging required all cases...
Pericytes isolated from the bovine retinal microvasculature retain characteristic features of their in vivo counterparts, such as presence glycogen deposits, long filamentous processes, prominent microfilament bundles and ability to display two distinct reversible phenotypes. Time-lapse video-microscopy demonstrated that pericytes tend overlap aggregate, even sparse cultures. After reaching confluence, they form multilayered areas retract away each other, resulting formation multicellular...
Involvement of the cervical lymph nodes is most important prognostic factor for patients with oral/oropharyngeal squamous cell carcinoma (OSCC), and decision whether to electively treat clinically negative necks remains a controversial topic. Sentinel node biopsy (SNB) provides minimally invasive method determining disease status basin, without need formal neck dissection. This technique potentially improves accuracy histologic nodal staging avoids overtreating three-quarters this patient...