A5089036657- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Oral health in cancer treatment
- Lung Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Voice and Speech Disorders
- Radiation Dose and Imaging
- Speech Recognition and Synthesis
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Colorectal and Anal Carcinomas
- Oral Health Pathology and Treatment
- Effects of Radiation Exposure
- Infectious Diseases and Mycology
The Christie NHS Foundation Trust
2013-2023
The Christie Hospital
2007-2023
University of Manchester
2010-2023
Royal Marsden NHS Foundation Trust
2009-2020
Queen Elizabeth Hospital Birmingham
2020
NIHR Surgical Reconstruction and Microbiology Research Centre
2020
King's College London
2020
Manchester Academic Health Science Centre
2014-2019
Centre Hospitalier Universitaire de Lille
2018
Cancer Research UK Manchester Institute
1991-2011
Abstract Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression clustered with the 10 well-known hypoxia-regulated (e.g., CA9, GLUT1, VEGF). To minimize random aggregation, strongly correlated up-regulated appearing >50% clusters defined a signature comprising 99 genes, which 27% previously known be associated. The median RNA an independent prognostic factor for...
Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than those HPV-negative tumours. There is interest in de-escalating their treatment but strategies are needed for risk stratification to identify subsets poor prognosis. This study investigated tumour-infiltrating lymphocytes (TILs) relation HPV tumour status and patient survival.
Failure of locoregional control is the main cause recurrence in advanced head and neck cancer. This multi-center trial aims to improve outcome two ways. Firstly, by redistribution radiation dose metabolically most FDG-PET avid part tumour. Hereby, a biologically more effective distribution might be achieved while simultaneously sparing normal tissues. Secondly, improving patient selection. Both cisplatin Epidermal Growth Factor Receptor (EGFR) antibodies like Cetuximab combination with...
Abstract Mucosal melanoma is rare and traditionally treated by radical surgery. A retrospective survey was made of 28 cases malignant mucosal the nasal cavity paranasal sinuses definitive radiotherapy. Initial complete regression observed in 22 out (79%). Absolute local control radiotherapy alone achieved 17 (61%) but follow-up limited many early death due to metastatic disease; actuarial disease-free survival 49% at 3 years. The approach for this site can be justified on basis achieved, low...
One hundred and three patients with primary parotid cancer treated surgically at the Christie Hospital, Manchester (1952-1992), were analysed to assess influence on survival of prognostic treatment-related factors. Thirty-seven by surgery alone (SG), 66 received post-operative radiation (SG+RT). Median follow-up was 12 years, minimum 5 years. The 10-year disease-specific rates for stage I, II III/IV 96%, 61% 17% respectively (P < 0.0001). various histological types segregated into patterns:...
Abstract Background There is a need to improve the systemic treatment of advanced adenoid cystic carcinoma (ACC). Response rates chemotherapy are poor and preliminary investigations molecularly targeted agents have been disappointing. In this study, we evaluate sorafenib, an oral multikinase inhibitor, which has attractive targeting profile for disease. Methods single‐arm phase II trial, patients with unresectable locally recurrent and/or metastatic ACC were treated sorafenib 400 mg bid....
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The accurate definition of organs at risk (OARs) is required to fully exploit the benefits intensity-modulated radiotherapy (IMRT) for head and neck cancer. However, manual delineation time-consuming there considerable inter-observer variability. This pertinent as function-sparing adaptive IMRT have increased number frequency OARs. We evaluated accuracy potential time-saving Smart Probabilistic Image Contouring Engine (SPICE) automatic segmentation define OARs salivary-, swallowing-...