A5024540647- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Prostate Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Cancer, Hypoxia, and Metabolism
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Thyroid Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cutaneous Melanoma Detection and Management
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
The Netherlands Cancer Institute
2016-2025
Palmetto Hematology Oncology
2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2021
Universitäres Kinderwunschzentrum Lübeck
2019
Princess Margaret Cancer Centre
2017
University Health Network
2017
University Medical Center Utrecht
2016
Ålesund Hospital
2013
Innsbruck Medical University
2013
Dutch Cancer Society
2011
Surgery for locoregionally advanced head and neck squamous cell carcinoma (HNSCC) results in 30‒50% five-year overall survival. In IMCISION (NCT03003637), a non-randomized phase Ib/IIa trial, 32 HNSCC patients are treated with 2 doses (in weeks 1 3) of immune checkpoint blockade (ICB) using nivolumab (NIVO MONO, n = 6, Ib arm A) or plus single dose ipilimumab (COMBO, 26, 6 B, 20 IIa) prior to surgery. Primary endpoints feasibility resect no later than week (phase Ib) primary tumor...
Repopulation of clonogenic tumor cells is inversely correlated with radiation treatment outcome in head and neck squamous cell carcinomas. A functional imaging tool to assess the proliferative activity tumors could improve patient selection for modifications be used evaluation early response. The PET tracer 3′-deoxy-3′-<sup>18</sup>F-fluorothymidine (<sup>18</sup>F-FLT) can image proliferation before during radiotherapy, it may provide biologic information useful radiotherapy planning. In...
IntroductionThe presence of previously unnoticed bilateral macroscopic salivary gland locations in the human nasopharynx was suspected after visualization by positron emission tomography/computed tomography with prostate-specific membrane antigen ligands (PSMA PET/CT). We aimed to elucidate characteristics this unknown entity and its potential clinical implications for radiotherapy.Materials methodsThe configuration PSMA-positive area evaluated a retrospective cohort consecutively scanned...
Failure of locoregional control is the main cause recurrence in advanced head and neck cancer. This multi-center trial aims to improve outcome two ways. Firstly, by redistribution radiation dose metabolically most FDG-PET avid part tumour. Hereby, a biologically more effective distribution might be achieved while simultaneously sparing normal tissues. Secondly, improving patient selection. Both cisplatin Epidermal Growth Factor Receptor (EGFR) antibodies like Cetuximab combination with...
The determination of lesion boundaries on FDG PET is difficult due to the point-spread blurring and unknown uptake activity within a lesion. Standard threshold-based methods for volumetric quantification usually neglect any size dependence are biased by signal-to-background ratio (SBR). A novel, model-based method hypothesized provide threshold levels independent f SBR allow accurate measurement volumes down resolution scanner. background-subtracted relative-threshold level (RTL) was...
Laparoscopic evaluation of sentinel nodes is useful for staging prostate cancer, but preoperative localization deep abdominal with planar lymphoscintigraphy difficult. We evaluated the value SPECT/CT detecting and localizing in cancer.(99m)Tc-nanocolloid was injected peri- intratumorally, guided by transrectal ultrasonography, 46 patients cancer intermediate prognosis. Patients underwent imaging after 15 min 2 h, laparoscopic node lymphadenectomy on same day. SPECT fused CT analyzed using...
Response monitoring with MRI during neoadjuvant chemotherapy (NAC) in breast cancer is promising, but knowledge of subtype essential. The aim the present study was to evaluate relevance subtypes for therapy response NAC 18F-FDG PET/CT.Evaluation included 98 women stages II and III cancer. PET/CTs were performed before after six or eight weeks NAC. FDG uptake quantified using maximum standardized values (SUVmax). Tumors divided into three subtypes: HER2-positive, ER-positive/HER2-negative,...
Objective To evaluate the clinical impact of 18 F ‐fluorodeoxyglucose ( FDG )‐positron‐emission tomography/computed tomography PET / CT ) scanning, compared with conventional staging contrast‐enhanced imaging CECT ). Patients and Methods The FDG‐PET results 96 consecutive patients bladder cancer were analysed. included in this study underwent standard chest abdomen/pelvis <4 weeks before . Based on original reports recorded tumour stage after imaging, preferred treatment strategies...
The aim of this study was to assess the accuracy (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT visualize lymph node metastases before start neoadjuvant chemotherapy and determine how often visualization is sufficiently prominent allow monitoring axillary response.Thirty-eight patients with invasive breast cancer >3 cm and/or metastasis underwent FDG PET/CT chemotherapy. results were compared those from ultrasonography fine-needle aspiration (FNA) cytology or sentinel...