A5051882396- Mycotoxins in Agriculture and Food
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Amino Acid Enzymes and Metabolism
- Fungal Biology and Applications
- Probiotics and Fermented Foods
- Acute Myeloid Leukemia Research
- Plant Pathogens and Fungal Diseases
- Microtubule and mitosis dynamics
- Advanced Breast Cancer Therapies
- Mycorrhizal Fungi and Plant Interactions
- Lymphoma Diagnosis and Treatment
- Milk Quality and Mastitis in Dairy Cows
- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Genomics and Chromatin Dynamics
- Food Safety and Hygiene
- Ion Channels and Receptors
- Diverse academic and cultural studies
- Angiogenesis and VEGF in Cancer
- RNA and protein synthesis mechanisms
- Potato Plant Research
- SARS-CoV-2 and COVID-19 Research
- Nail Diseases and Treatments
- Organic Food and Agriculture
Cancer Research UK
2019-2024
University of Milan
1975-2011
Cancer Research Horizons
2009
The University of Melbourne
2006
Novartis (Switzerland)
2002-2005
Novartis (United Kingdom)
2004
Vita-Salute San Raffaele University
1998
Patients with neuroblastoma infused GD2-directed CAR-T cells experienced immune activation and transient tumor regressions without neurotoxicity.
Inhibition of monocarboxylate transporter (MCT) 1-mediated lactate transport may have cytostatic and/or cytotoxic effects on tumor cells. We report results from the dose-escalation part a first-in-human trial AZD3965, first-in-class MCT1 inhibitor, in advanced cancer.
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown. In this study, we demonstrate that translocates from nucleoli interphase spindle mitosis as an RNA–protein complex includes 18S ribosomal RNA. Functionally, depletion of caused multiple mitotic defects, including formation unstructured spindles, multipolar and...
Here we focus on discrimination problems where the number of predictors substantially exceeds sample size and propose a Bayesian variable selection approach to multinomial probit models. Our method makes use mixture priors Markov chain Monte Carlo techniques select sets variables that differ among classes. We apply our methodology problem in functional genomics using gene expression profiling data. The aim analysis is identify molecular signatures characterize two different stages rheumatoid...
Abstract Background We evaluated the therapeutic potential of combining monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 with mitochondrial respiratory Complex I IACS-010759, for treatment diffuse large B-cell lymphoma (DLBCL), a clinically actionable strategy to target tumour metabolism. Methods and IACS-010759 sensitivity were determined in DLBCL cell lines xenograft models. Lactate concentrations, oxygen consumption rate metabolomics examined as mechanistic endpoints. In vivo plasma...
3115 Background: Tumours rely on lactate transporters (MCT1-4) to maintain glycolytic flux and avoid intracellular acidification. In haematological tumours the MCT1 transporter acts as a pyruvate exporter. AZD3965 is potent specific inhibitor of causing accumulation. vivo efficacy was observed in xenografts DLBCL BL, expressing high levels no or low MCT4. phase I (NCT01791595) dose-escalation an oral recommended 2 dose (RP2D) 10mg twice-daily (bd) determined. Pharmacokinetic (PK) showed...
We have investigated the glycosylation, disulfide bonding, and subunit structure of mouse TRPM8. To do this, amino-terminal c-myc or hemagglutinin epitope-tagged proteins were incorporated expressed in Chinese hamster ovary cells. These modifications had no obvious effects on channel function intracellular calcium imaging assays upon application agonists, icilin menthol, cold temperatures. Unmodified TRPM8 migrates with an apparent mass 129 kDa can be glycosylated cells to give glycoproteins...
Despite the effectiveness of endocrine therapies to treat estrogen receptor-positive (ER+) breast tumours, two thirds patients will eventually relapse due de novo or acquired resistance these agents. Cancer Stem-like Cells (CSCs), a rare cell population within tumour, accumulate after anti-estrogen treatments and are likely contribute their failure. Here we studied role p21-activated kinase 4 (PAK4) as promising target overcome disease progression in ER + cancers. PAK4 predicts for tamoxifen...
Endothelial cell differentiation is a crucial step in angiogenesis. Here we report the identification of EDF-1, novel gene product that down-regulated when endothelial cells are induced to differentiate vitro. The cDNA encoding EDF-1 was isolated by RNA fingerprinting from human exposed immunodeficiency virus type 1 Tat, viral protein known be angiogenic. deduced amino acid sequence encodes basic intracellular 148 acids homologous MBF1 (multiprotein-bridging factor 1) silkworm Bombyx mori...
We describe the properties of a novel nonpeptide kinin B 1 receptor antagonist, NVP‐SAA164, and demonstrate its in vivo activity models inflammatory pain transgenic mice expressing human receptor. NVP‐SAA164 showed high affinity for expressed HEK293 cells ( K i 8 n M ), inhibited increases intracellular calcium induced by desArg 10 kallidin (desArg KD) (IC 50 33 ). While similar was observed monkey fibroblasts 7.7 no rat Cos‐7 cells. In which native deleted gene encoding inserted (hB...
Mice, rats, guineapigs and rabbits that were apparently healthy did not present skin lesions examined for the presence of dermatophytes. A small proportion them found to be carriers Trichophyton mentagrophytes, rubrum, Microsporum canis (8/140 = 5·7% mice; 2/185 1·1% rats; 1/70 1·4% guineapigs; 1/215 0·5% rabbits).
The essential oils are well known for their antibacteric, antomycotic and insecticide effects. In this research the activity of Rosemary oil has been tested in vitro versus different moulds, common contaminants food feed, as Aspergillus flavus, ochraceus, niger, ustus, Penicillium expansum, aurantio-griseum, Fusarium moniliforme. (produced Sardegna, Italy) shows a efficacy against various moulds his seems to be produced by borneol, α-pinene, eucalyptol, camphor limonene. genus showing an...
Abstract Background In the COVID-19 pandemic, a number of phase II and III randomized trials were launched to evaluate effectiveness camostat, an orally administered TMPRSS2 inhibitor previously approved for other indications, treating SARS-CoV-2 infections. Owing rapidly changing landscape during many these unable reach completion. Further, methods synthesizing data that not completed critical. Methods This study aimed consolidate global evidence by identifying placebo-controlled, camostat...