A5102883734- Oral Health Pathology and Treatment
- Bone Tissue Engineering Materials
- Oral microbiology and periodontitis research
- Orthopaedic implants and arthroplasty
- Obsessive-Compulsive Spectrum Disorders
- Dental Implant Techniques and Outcomes
- Streptococcal Infections and Treatments
- Celiac Disease Research and Management
- Autism Spectrum Disorder Research
- Immune Response and Inflammation
- Oil and Gas Production Techniques
- Drilling and Well Engineering
- Salivary Gland Disorders and Functions
- Health Systems, Economic Evaluations, Quality of Life
- Tissue Engineering and Regenerative Medicine
- Titanium Alloys Microstructure and Properties
- Genetic factors in colorectal cancer
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- BIM and Construction Integration
- Genetics and Neurodevelopmental Disorders
- Health and Medical Research Impacts
- Lipoproteins and Cardiovascular Health
- Autoimmune and Inflammatory Disorders Research
- dental development and anomalies
Commonwealth Cancer Center
2023
The University of Notre Dame Australia
2020-2021
Eastman Dental Hospital
2007-2019
University College London
2008-2019
University of Surrey
2019
Gray's Inn
1998-2016
UConn Health
2007
University of Leeds
2006
Cancer Research UK
2006
St James's University Hospital
2006
Severe periodontitis is associated with elevated inflammatory markers in otherwise healthy populations. However, the nature of this association has not been determined. Our aim was to assess whether degree response periodontal therapy changes serological systemic inflammation. Ninety-four systemically subjects severe generalized participated a prospective six-month blind intervention trial. Periodontal parameters and [C-reactive Protein (CRP) Interleukin-6 (IL-6)] were evaluated prior 2 6...
There is strong evidence that genetic as well environmental factors affect the development of periodontitis, and some suggestion aggressive chronic forms disease share same predisposition. This study addresses hypothesis there are both shared unique associations in these periodontitis. A sample 51 patients with disease, 57 100 healthy controls was recruited for this study. Ten functional polymorphisms 7 candidate genes were genotyped. The results show statistically significant (p ≤ 0.05)...
Abstract Objectives: The aim of this study was to assess the systemic effects treating severe widespread periodontitis in a population otherwise healthy individuals by examining treatment associated changes markers inflammation that are also implicated cardiovascular atherosclerotic diseases. potential impact specific polymorphisms cytokine genes known influence both and diseases examined. Materials Methods: A convenience sample patients affected with generalised enrolled into prospective...
Growing evidence suggests that individual genetic susceptibility may influence the host’s response to infections. The aim of this project was study whether gene polymorphisms inflammatory markers are associated with presence viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adults diagnosed generalized aggressive periodontitis Fc receptors, formyl peptide receptor, Interleukin-6, tumor necrosis factor-α, and vitamin D receptor polymorphisms. numbers Actinobacillus...
The etiology of the reduced marginal bone loss observed around platform-switched implant-abutment connections is not clear but could be related to release variable amounts corrosion products. present study evaluated effect different concentrations metal ions released from implant abutment couples on osteoblastic cell viability, apoptosis and expression genes resorption.Osteoblastic cells were exposed five conditions culture media prepared containing (titanium, aluminum, vanadium, cobalt,...
We have previously reported that loss-of-function mutations in the cathepsin C gene (CTSC) result Papillon-Lefèvre syndrome, an autosomal recessive condition characterized by palmoplantar keratosis and early-onset, severe periodontitis. Others also CTSC patients with prepubertal periodontitis, but without any skin manifestations. The possible role of variants more common types non-mendelian, periodontitis ("aggressive periodontitis") has not been investigated. In this study, we investigated...
The susceptibility to develop coeliac disease (CD) has a strong genetic component, which is not entirely explained by HLA associations. Two previous genome wide linkage studies have been performed identify additional loci outside this region. These both used sib‐pair design and produced conflicting results. Our aim non‐MHC contributing using family based study. We search in 16 highly informative multiply affected pedigrees 400 microsatellite markers with an average spacing of 10 cM. Linkage...
Growing evidence suggests that individual genetic susceptibility may influence the host's response to infections. Previously, we showed a common variation in interleukin (IL)-6 gene was associated with increased odds of detection periodontal pathogens from individuals aggressive periodontitis. The aim this study investigate association between IL-6 polymorphisms and periodontopathogenic bacteria larger, ethnically mixed population subjects periodontitis.Genomic DNA extracted 107 diagnosed...
Interleukin-6 (IL-6) polymorphisms have been shown to affect IL-6 promoter activity. This study investigated the possible role of genetic and haplotypes in predisposition aggressive periodontitis (AgP).A case-control association on 224 AgP patients 231 healthy controls was performed order detect differences genotype distributions five single nucleotide (SNPs) located region gene.The -1363 polymorphism associated with a diagnosis subjects all ethnicities (p=0.006, adjusted logistic...
The aim of this analysis was to investigate the relationship between a vitamin D receptor (VDR) polymorphism and diagnosis progression periodontitis.Data were derived from two different studies, including 231 subjects with healthy periodontium, 224 aggressive periodontitis 79 chronic (CP) patients in case-control investigation. Sixty-one these CP also took part an observational study 1-year follow-up, which determined at subject level. All 534 provided blood sample genomic DNA extracted VDR...
Objectives: Previous studies of the interleukin-1 receptor antagonist (IL-1 RN) have found an increased frequency associated variable number tandem repeat (VNTR) allele 2 for ulcerative colitis (UC) and further evidence has been reported that this is with severity several other inflammatory conditions. The HLA type UC patients also implicated in extent disease as presence perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA). We therefore decided to test hypothesis p-ANCA, or IL-1 RN...
Recent reports of cytogenetic abnormalities linked to psychiatric illness and the localisations genes for dopamine (D2) receptor tyrosinase on long arm chromosome 11 have suggested that susceptibility loci schizophrenia manic depression might be situated in this region. We could find no evidence linkage five Icelandic pedigrees between markers region, we excluded candidate coding D2 tyrosinase. conclude mutations at region are not a common cause population studied.
Abstract Introduction: Neutrophils (PMN) in aggressive periodontitis (AgP) patients have been reported to be hyperactive especially with regards superoxide production. Polymorphisms genes influencing PMN function proposed as candidate risk factors for AgP. The aim of this study was test the association specific gene polymorphisms affecting functions Material and Methods: Two hundred twenty‐four confirmed diagnosis AgP 231 subjects healthy periodontium took part study. A blood sample...
Abstract The current gold standard material for orthopedic applications is titanium (Ti), however, other materials such as cobalt–chromium–molybdenum (CoCrMo) are often preferred due to their wear resistance and mechanical strength. This study investigates if the bioactivity of CoCrMo can be enhanced by coating surface with oxide (TiO 2 ) atmospheric pressure chemical vapor deposition (CVD), thereby replicating layer found on Ti. CoCrMo, TiO ‐coated (CCMT) Ti substrates were used this study....
Previous studies have demonstrated a relationship between obsessive-compulsive disorder or behavior and Gilles de la Tourette syndrome. It has been hypothesized that the serotonergic system is implicated in etiology of disorder. Therefore, authors investigated whether genetic variation receptor modifying enzyme were associated with Tourette's syndrome.A linkage analysis using DNA blood group markers was carried out large British kindred multiply affected syndrome, chronic motor tics,...
Objectives To localize genes influencing the susceptibility to Gilles de la Tourette syndrome (GTS) and associated chronic multiple tics (CMT). Method A single, large, affected pedigree containing 35 subjects diagnosed with GTS a further 14 CMT was genotyped for markers spanning autosomes. Linkage analysis carried out using classical lod score model-free analysis. All were subjected two-point analysis, producing result significant at P<0.005 three-point adjacent markers. Results The...