A5030635214- Electron Spin Resonance Studies
- Lanthanide and Transition Metal Complexes
- X-ray Diffraction in Crystallography
- Advanced NMR Techniques and Applications
- Crystallization and Solubility Studies
- Spectroscopy and Quantum Chemical Studies
- DNA and Nucleic Acid Chemistry
- Phenothiazines and Benzothiazines Synthesis and Activities
- Various Chemistry Research Topics
- Magnetism in coordination complexes
- Radical Photochemical Reactions
- Photochemistry and Electron Transfer Studies
- Diverticular Disease and Complications
- Nuclear Physics and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Chemical Reactions and Mechanisms
- Abdominal Trauma and Injuries
- Atomic and Subatomic Physics Research
- Urological Disorders and Treatments
- Synthesis and Catalytic Reactions
- Advanced MRI Techniques and Applications
- Crystal structures of chemical compounds
University of Göttingen
1972-2024
Max Planck Institute for Multidisciplinary Sciences
2022-2024
Max Planck Institute for Biophysical Chemistry
2018-2021
Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides to deoxyribonucleotides, thereby playing a key role in DNA replication and repair. Escherichia coli class Ia RNR is an α2β2 enzyme complex that uses reversible multistep radical transfer (RT) over 32 Å across its two subunits, α β, initiate, using metallo-cofactor β2, nucleotide α2. Each step proposed involve distinct proton-coupled electron-transfer (PCET) process. An unresolved RT involving Y356(β) Y731(α) α/β...
The combination of fluorine labeling and pulsed electron-nuclear double resonance (ENDOR) is emerging as a powerful technique for obtaining structural information about proteins nucleic acids. In this work, we explored the capability Mims 19F ENDOR experiments on reporting intermolecular distances in trityl- 19F-labeled DNA duplexes at three electron paramagnetic (EPR) frequencies (34, 94, 263 GHz). For spin labeling, used hydrophobic Finland trityl radical hydrophilic OX063 radical....
Pulsed 19F ENDOR spectroscopy provides a selective method for measuring angstrom to nanometer distances in structural biology. Here, the performance of at fields 3.4 T and 9.4 is compared using model compounds containing one three atoms. CF3 groups are included two compounds, which possible occurrence uniaxial rotation might affect distance distribution. At T, pronounced asymmetric features observed many presented spectra. Data analysis by spectral simulations shows that these arise from...
ENDOR spectroscopy is a fundamental method to detect nuclear spins in the vicinity of paramagnetic centers and their mutual hyperfine interaction. Recently, site-selective introduction 19F as labels has been proposed tool for ENDOR-based distance determination biomolecules, complementing pulsed dipolar range angstrom nanometer. Nevertheless, one main challenge still consists its spectral analysis, which aggravated by large parameter space broad resonances from interactions. Additionally, at...
Photolysis of a platinum(II) azide complex in the presence styrenes enables C=C double bond cleavage upon dissociative olefin imination to aldimido (Pt
β-Peptides are an interesting new class of transmembrane model peptides based on their conformationally stable and well-defined secondary structures. Herein, we present the synthesis paramagnetic β-amino acid β3 -hTOPP (4-(3,3,5,5-tetramethyl-2,6-dioxo-4-oxylpiperazin-1-yl)-d-β3 -homophenylglycine) that enables investigations β-peptides by EPR spectroscopy. This amino adds to the, date, sparse number β-peptide spin labels. Its performance was evaluated investigating helical turn a 314...
F electron-nuclear double resonance (ENDOR) spectroscopy is emerging as a method of choice to determine molecular distances in biomolecules the angstrom nanometer range. However, line broadening mechanisms
Es wird über Messungen der Gleichstromleitfähigkeit σ und komplexen Dielektrizitätszahl ϵ = ϵ′ − j ϵ″ bei 10 GHz an Einkristallen zweier halbleitender, organischer Ladungsübertragungskomplexe berichtet. Beide Komplexe wurden aus N-Äthyl-phenothiazin (EPT) Jod hergestellt. Leitfähigkeit Realteil 20°C betragen beim EPT–Jod(I)-Komplex 1,5 (Ωcm)−1, 500, EPT–Jod(II)-Komplex 5 10−4 7 bzw. 12 (anisotrop). Beim sind die dielektrischen Verluste Temperaturen unterhalb −50°C wesentlich höher als...
Measurements of the electrical ac conductivity σac and relative dielectric number ϵ′ have been performed on single crystals semiconducting complex (N-methyl-phenothiazine)2 · (Iodine2)3 in frequency range 0.3 to 3.0 GHz. The very strong conduction anisotropy these crystals, already established by dc measurements, could be confirmed high measurements. Anisotropy ratios about 1:30:2000 observed for as well ϵ′. Because this behaviour may regarded quasi one-dimensional conductors. In temperature...
The combination of 19F-labeling and pulsed electron-nuclear double resonance (ENDOR) is a powerful method for obtaining structural information about biomolecules. In this work, we demonstrated the capability Mims 19F-ENDOR experiments on measuring intermolecular distances in trityl- 19F-labeled DNA duplexes at three electron paramagnetic frequencies (34, 94, 263 GHz).