A5078844770- Synthetic Organic Chemistry Methods
- Receptor Mechanisms and Signaling
- Asymmetric Synthesis and Catalysis
- Renin-Angiotensin System Studies
- Synthesis and Biological Evaluation
- Catalytic Alkyne Reactions
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Protein Kinase Regulation and GTPase Signaling
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Coordination Chemistry and Organometallics
- Phagocytosis and Immune Regulation
- Neuroendocrine regulation and behavior
- Chemical Synthesis and Reactions
- Quinazolinone synthesis and applications
- Carbohydrate Chemistry and Synthesis
- Enzyme function and inhibition
- Synthesis of Organic Compounds
- Organometallic Complex Synthesis and Catalysis
- Cyclization and Aryne Chemistry
- Neuropeptides and Animal Physiology
- Glycosylation and Glycoproteins Research
- Neuroscience and Neuropharmacology Research
- Carbon dioxide utilization in catalysis
Sunovion (United States)
2016-2020
Vion Pharmaceuticals (United States)
2016-2020
Biogen (United States)
2015-2016
Pfizer (United States)
2004-2012
Ann Arbor Center for Independent Living
2002-2010
University of Michigan
2001-2004
University of California, Irvine
1996-2003
Irvine University
1993-1999
Central College
1994
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn improved method for the synthesis of enantiomerically pure amino acid ester isocyanatesJames S. Nowick, Noel A. Powell, Tram M. Nguyen, and Glenn NoronhaCite this: J. Org. Chem. 1992, 57, 26, 7364–7366Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/jo00052a069https://doi.org/10.1021/jo00052a069research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular scaffolds. I. Intramolecular hydrogen bonding in a family of di- and triureasJames S. Nowick, Noel A. Powell, Eduardo J. Martinez, Eric M. Smith, Glenn NoronhaCite this: Org. Chem. 1992, 57, 14, 3763–3765Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/jo00040a007https://doi.org/10.1021/jo00040a007research-articleACS PublicationsRequest reuse...
The nuclear hormone receptor RORγ regulates transcriptional genes involved in the production of pro-inflammatory interleukin IL-17 which has been linked to autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. This activity is modulated through a protein-protein interaction involving activation function 2 (AF2) helix on ligand binding domain conserved LXXLL motif coactivator proteins. Our goal was develop specific inverse agonist that would help...
The enantioselective total synthesis of the cytotoxic plecomacrolide natural product formamicin (1) is described. Key aspects this include efficient transacetalation reactions MOM ethers 28 and 38 to form seven-membered formyl acetals 29 39, a late-stage Suzuki cross-coupling reaction highly functionalized vinyl boronic acid 6 iodide 7, β-selective glycosidation β-hydroxy ketone 4 with 2,6-dideoxy-2-iodoglucopyranosyl fluoride 3, global desilylation penultimate intermediate 77 mediated by in...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDialkylzinc Additions to 4-Acetoxy-1,3-dioxanes: A Highly Stereoselective Route Protected anti-1,3-DiolsScott D. Rychnovsky and Noel A. PowellView Author Information Department of Chemistry, University California, Irvine, California 92697-2025Cite this: J. Org. Chem. 1997, 62, 19, 6460–6461Publication Date (Web):September 1997Publication History Received2 July 1997Published online19 September inissue 1...
Propargylic 1,2-anti-diol derivatives 2 and 10 are prepared in high yield excellent diastereoselectivity by addition of α-alkoxypropargylstannanes 4a 4b to aldehydes the presence BuSnCl3. We also introduce use KF on Celite as a convenient mild reagent for removal organotin waste products these reactions.
An efficient and highly concise synthesis of 6, corresponding to the C(1)−C(11) fragment formamicin (1), has been accomplished by a route utilizing diastereoselective lactate aldol reaction set C(6) tertiary ether TES−OTf mediated transketalization methoxymethyl C(25) PMB seven-membered methylene acetal unit (see 37 → 38).
Dialkylzincs couple with 4-acetoxy-6-alkyl-1,3-dioxanes in the presence of trimethylsilyl triflate (TMSOTf) to form trans-4,6-dialkyl-1,3-dioxanes excellent diastereoselectivities. These dioxanes could be deprotected yield anti-1,3-diols. A variety functional groups are tolerated dialkylzinc, although silyl and benzyl ethers led diminished Substituents at C5-position dioxane ring have little effect on selectivity, while small C2 (acetal) substituents slightly reduced diastereoselectivity....
[reaction: see text] Chiral 1-aryl-6-(hydroxymethyl)-2-ketopiperazines can be prepared via an operationally simple, 6-exo epoxide ring-opening cyclization to form the ketopiperazine C6-N1 bond in high yields and with excellent enantiomeric purity.
A mouse-based assay (SmartCube) was used for both screening and lead optimization of a novel antipsychotic.