Marcela Cristina Corrêa de Freitas

ORCID: 0000-0002-6109-7059
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About
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Research Areas
  • Virus-based gene therapy research
  • Hemophilia Treatment and Research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Animal Genetics and Reproduction
  • Blood Coagulation and Thrombosis Mechanisms
  • CAR-T cell therapy research
  • Monoclonal and Polyclonal Antibodies Research
  • Blood properties and coagulation
  • Antifungal resistance and susceptibility
  • Congenital heart defects research
  • Immunodeficiency and Autoimmune Disorders
  • Prenatal Screening and Diagnostics
  • Biotin and Related Studies
  • Tissue Engineering and Regenerative Medicine
  • Genomic variations and chromosomal abnormalities
  • Biochemical and Molecular Research
  • Organ Transplantation Techniques and Outcomes
  • Mesenchymal stem cell research
  • Fungal Infections and Studies
  • Microbial Natural Products and Biosynthesis
  • Virology and Viral Diseases
  • Vitamin K Research Studies
  • Platelet Disorders and Treatments
  • Liver Disease Diagnosis and Treatment
  • Liver physiology and pathology

Universidade de São Paulo
2008-2021

Clinics Hospital of Ribeirão Preto
2017-2021

Nowadays recombinant factor VIII is produced in murine cells including Chinese hamster ovary (CHO) and baby kidney (BHK). Previous studies, using the leukemia virus-derived retroviral vector pMFG-FVIII-P140K, modified two human cell lines, HepG2 Hek293 to produce VIII. In order characterize these cells, present study aimed analyze integration pattern of pMFG-FVIII-P140K. This used ligation-mediated polymerase chain reaction locate site viral by sequencing products. The sequences were...

10.1016/j.bjhh.2014.03.002 article EN cc-by-nc-nd Revista Brasileira de Hematologia e Hemoterapia 2014-05-01
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