A5001492783- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- Protease and Inhibitor Mechanisms
- Immune cells in cancer
- Cardiac Structural Anomalies and Repair
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Connective tissue disorders research
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
University of Nebraska Medical Center
2021-2022
East Carolina University
2019-2021
Evidence suggests the existence of an intracardiac dopaminergic system that plays a pivotal role in regulating cardiac function and fibrosis through G-protein coupled receptors, particularly mediated by dopamine receptor 3 (D3R). However, expression receptors tissue their fibroblast is unclear. In this brief report, first we determined D1R D3R both left ventricle (LV) fibroblasts. Then, explored proliferation migration cell cultures using genetic pharmaceutical approaches; specifically,...
Dopamine is a neurotransmitter heavily involved in neural pathways regulating the reward response, body movement, mood, and cognitive function. As such, much of research on dopamine its five receptor subtypes has been conducted to observe vivo function each subtype neurological disorders. However, recent studies by colleagues from our institution have suggested that D3Rs may play role cardiac‐related aging, as 2‐month old D3 knock‐out (D3KO) mice show age‐related changes cardiac similar...