A5039846129- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Inflammatory mediators and NSAID effects
- Knee injuries and reconstruction techniques
- Veterinary Equine Medical Research
- Shoulder Injury and Treatment
- Muscle metabolism and nutrition
- Sports injuries and prevention
University of Copenhagen
2010-2015
Bispebjerg Hospital
2010
Abstract Introduction The microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order reveal changes biochemical markers of cartilage and inflammation, intraarticularly synovium, response a single bout mechanical loading. Methods Thirty-one female subjects OA were randomized non-exercise (NEx) or exercise (Ex) groups. Following acute resistance (25 sets 10 repetitions at 60% 1 Repetition Maximum) none (NEx), peripheral nerve blocks just below inguinal ligament...
Brown adipose tissue is a promising therapeutic target for opposing obesity, glucose intolerance and insulin resistance. The ability to modulate gene expression in mature brown adipocytes important understand adipocyte function delineate novel regulatory mechanisms of non-shivering thermogenesis. aim this study was optimize lipofection-based small interfering RNA (siRNA) transfection protocol efficient silencing adipocytes. We determined that critical parameter deliver the siRNA by reverse...
Background Achilles tendinopathy is a painful inflammatory condition characterized by swelling, stiffness and reduced function of the tendon. Kager's fat pad an adipose tissue located in area anterior to Observations reveal close physical interplay between its surrounding structures during movement ankle, suggesting that may stabilize protect mechanical ankle joint. Aim The aim this study was characterize whether accompanied changes expression markers metabolic enzymes pad. Methods A biopsy...
Abstract Objective: Estrogen‐related receptors (ERRs) are important regulators of energy metabolism. Here we investigated the hypothesis that ERRγ impacts on differentiation and function brown adipocytes. Design Methods: We characterize expression in adipose tissues cell models investigate effects modulating ERR? activity UCP1 gene metabolic features white Results: was preferentially expressed compared to fat depots, induced during cold‐induced browning subcutaneous tissue adipogenesis....