A5080242106- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Exercise and Physiological Responses
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Congenital Heart Disease Studies
- Sports Performance and Training
- Cancer survivorship and care
- Cardiovascular Effects of Exercise
- Mesenchymal stem cell research
- Pharmacological Effects and Assays
- Osteoarthritis Treatment and Mechanisms
- Diabetes Treatment and Management
- Sports injuries and prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal and reproductive studies
- Pancreatic function and diabetes
- Shoulder Injury and Treatment
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Autoimmune and Inflammatory Disorders Research
- Diabetes Management and Research
- Cardiovascular Conditions and Treatments
- Knee injuries and reconstruction techniques
Arla Foods (Denmark)
2018-2024
Aarhus University
2004-2024
Bispebjerg Hospital
2007-2018
University of Copenhagen
2009-2018
Lund University
2014
Rigshospitalet
2014
Copenhagen University Hospital
2014
Karolinska University Hospital
2014
Karolinska Institutet
2014
Aarhus University Hospital
2014
The Fontan procedure has improved survival in children with functionally univentricular hearts. With time, however, complications such as reduced exercise capacity are seen more frequently. Exercise intolerance is multifactorial, but pulmonary vascular resistance probably plays a crucial role. Elevated been associated raised levels of endothelin-1, which common both before and after operations. Treatment endothelin-1 receptor antagonists could theoretically improve cardiopulmonary...
Abstract Introduction The microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order reveal changes biochemical markers of cartilage and inflammation, intraarticularly synovium, response a single bout mechanical loading. Methods Thirty-one female subjects OA were randomized non-exercise (NEx) or exercise (Ex) groups. Following acute resistance (25 sets 10 repetitions at 60% 1 Repetition Maximum) none (NEx), peripheral nerve blocks just below inguinal ligament...
Despite the widespread consumption of nonsteroidal anti-inflammatory drugs (NSAIDs), influence these on muscle satellite cells is not fully understood. The aim present study was to investigate effect a local NSAID infusion after unaccustomed eccentric exercise in vivo human skeletal muscle. Eight young healthy males performed 200 maximal contractions with each leg. An infused via microdialysis catheter into vastus lateralis one leg (NSAID leg) before, during, and for 4.5 h exercise, other...
To investigate the influence of lifelong endurance running on satellite cell pool type I and II fibres in healthy human skeletal muscle.Muscle biopsies were collected from 15 old trained men (O-Tr) who had been 43 ± 16 (mean SD) kilometres a week for 28 9 years. Twelve age-matched untrained (O-Un) group young recruited comparison. Frozen sections immunohistochemically stained Pax7, myosin laminin, which fibre area, number cells, relationship between these variables determined.In O-Un O-Tr,...
This study aimed to assess the effects of 20 wk resistance exercise training with or without protein supplementation on body composition, muscle mass, strength, physical performance, and aerobic capacity in prostate cancer patients receiving androgen deprivation therapy (ADT).Sixty ADT were randomly assigned perform 31 g whey (EX + PRO, n = 30) placebo PLA, 30), consumed immediately after every night before sleep. A separate control group (CON, 36) only received usual care. At baseline wk,...
Unaccustomed exercise leads to satellite cell proliferation and increased skeletal muscle protein turnover. Several growth factors cytokines may be involved in the adaptive responses. Non‐steroidal anti‐inflammatory drugs (NSAIDs) negatively affect regeneration adaptation animal models, inhibit exercise‐induced synthesis humans. However, cellular mechanisms eliciting these responses remain unknown. Eight healthy male volunteers performed 200 maximal eccentric contractions with each leg. To...
Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β (GSK3β) forkhead box O (FoxO) pathways, but it unknown how these pathways are regulated in critically ill human muscle. To describe factors involved regulation, we investigated the phosphorylation expression key protein synthesis breakdown thigh skeletal intensive care unit (ICU) patients compared with healthy controls.ICU were systemically...
Introduction: Rheumatoid arthritis (RA) is often associated with diminished muscle mass, reflecting an imbalance between protein synthesis and breakdown.To investigate the anabolic potential of both exercise nutritional intake we investigated rate signaling response in patients RA compared to healthy controls.Methods: Thirteen (age range 34-84 years; diagnosed for 1-32 years, median 8 years) were individually matched 13 controls gender, age, BMI activity level (CON).Plasma levels C-reactive...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat tendinopathy, but evidence for this treatment is lacking, and little known regarding effects of NSAIDs on human tendinopathic tendon. This study investigated the NSAID (ibuprofen) tendon, with changes in gene expression as primary outcome, tendon pain, function, blood flow secondary outcomes. Twenty-six adults (16 men, 10 women), diagnosed chronic Achilles were randomized 1-wk ibuprofen (600 mg ×3/day) (n = 13) or...
The relationship between fiber size and myonuclear content is poorly understood.Biopsy cross-sections from young old trained untrained healthy individuals were analyzed for area myonuclei, 2 fiber-size-dependent cluster analyses performed.When comparing fibers of similar size, no effect training or age was found domain. There a linear myonuclei per (r = 0.99; P < 0.001) non-linear domain 0.97-0.99; 0.0001), with markedly smaller in <3,000 µm(2). A higher proportion type II µm(2) observed the...
Testing of the ventilatory threshold (VT) and maximal oxygen uptake (VO2 peak) is relevant for evaluation a range training studies, clinical trials cross-sectional studies. Due to possible learning effect, familiarization test often performed increase reproducibility. However, limited research has investigated this effect reproducibility exercise testing. The most appropriate ways determine VT VO2 peak are not clear, study evaluated two approaches (V-slope combined method) determination five...
Key point Erythropoietin (Epo) treatment may induce myogenic differentiation factor (MyoD) expression and prevent apoptosis in satellite cells (SCs) murine vitro models. Endurance training stimulates SC proliferation vivo human skeletal muscle. In the present study, we show, muscle, that with an Epo‐stimulating agent (darbepoetin‐α) increases content of MyoD + SCs healthy young men. Moreover, report Epo receptor mRNA is expressed adult SCs, suggesting directly target through ligand‐receptor...
To examine whether calcium type and co-ingestion with protein alter gut hormone availability.Healthy adults aged 26 ± 7 years (mean SD) completed three randomized, double-blind, crossover studies. In all studies, arterialized blood was sampled postprandially over 120 min to determine GLP-1, GIP PYY responses, alongside appetite ratings, energy expenditure pressure. study 1 (n = 20), treatments matched for total content (1058 mg) were compared: citrate (CALCITR); milk minerals rich in (MILK...
Androgen deprivation therapy (ADT) forms the cornerstone in prostate cancer (PCa) treatment. However, ADT also lowers skeletal muscle mass.To identify impact of with and without resistance exercise training on fiber characteristics PCa patients.Twenty-one patients (72 ± 6 years) starting were included. Tissue samples from vastus lateralis assessed at baseline after 20 weeks usual care (n = 11) or 10). Type I II distribution, size, myonuclear capillary contents determined by...
Prostaglandins are known to be involved in the regulation of local blood flow within human skeletal muscles during exercise, and concentration prostaglandins increases locally systemically response exercise. The systemic release can inhibited by oral intake nonsteroidal anti-inflammatory drugs (NSAIDs). However, study role prostaglandins, formation tissue must controlled. Microdialysis enables determination concentrations water-soluble substances tissue. In present study, microdialysis...