A5049892715- Chronic Disease Management Strategies
- Health disparities and outcomes
- Birth, Development, and Health
- Family Dynamics and Relationships
- Nutritional Studies and Diet
- Assisted Reproductive Technology and Twin Pregnancy
- Health Systems, Economic Evaluations, Quality of Life
- Health Promotion and Cardiovascular Prevention
- Medical Coding and Health Information
- demographic modeling and climate adaptation
- Obesity, Physical Activity, Diet
- Geriatric Care and Nursing Homes
- Maternal Mental Health During Pregnancy and Postpartum
- Demographic Trends and Gender Preferences
- Cancer survivorship and care
- Nutrition and Health in Aging
- Global Health Care Issues
- Childhood Cancer Survivors' Quality of Life
- Frailty in Older Adults
- Gender, Labor, and Family Dynamics
- Healthcare innovation and challenges
- Intergenerational Family Dynamics and Caregiving
- Health Policy Implementation Science
- Health, Environment, Cognitive Aging
- Global Health Workforce Issues
Southampton General Hospital
2023-2025
University of Southampton
2019-2025
Purpose We have established the SAIL MELD-B electronic cohort (e-cohort SMC) and children Young adults e-cohort (SMYC) as a part of Multidisciplinary Ecosystem to study Lifecourse Determinants Prevention Early-onset Burdensome Multimorbidity (MELD-B) project. Each has been created investigate develop deeper understanding lived experience ‘burdensomeness’ multimorbidity by identifying new clusters burdensomeness concepts, exploring early life risk factors modelling hypothetical prevention...
If you work in public health or epidemiology, will be familiar with the term 'modifiable risk factors'.Searching PubMed December 2023 for titles that included risk' returned 1222 results.Expanding this search to include both and abstracts 13,958 results.The often refers behaviours such as smoking, alcohol intake, exercise, diet.However, there does not seem a specific definition of what is classed 'modifiable' context ill health.Although also used refer factors indirectly affecting health,...
Objective To investigate associations between clustered adverse neonatal events and later-life multimorbidity. Design Secondary analysis of birth cohort data. Setting Prospective study individuals born in Britain one week 1970. Population Respondents provided data at (n = 17,196), age 34 11,261), 38 9,665), 42 9,840), 46 8,580). Methods Mixed components determined included factors, ‘Birthweight’; ‘Neonatal cyanosis’; cerebral signs’; illnesses’; breathing difficulties’; ‘Prolonged duration...
Background Living with multiple long-term conditions (MLTCs) involves ‘work’. A recent qualitative synthesis identified eight patient-centred work themes: ‘learning and adapting’, ‘accumulation complexity’, ‘investigation monitoring’, ‘health service administration’ ‘symptom’, ‘emotional’, ‘medication’ ‘financial’ work. These themes may be underrepresented in electronic health records (EHRs). This study aimed to evaluate the representation of these their constituent concepts EHR data a...
Social, biological and environmental factors in early-life, defined as the period from preconception until age 18, play a role shaping risk of multiple long-term condition multimorbidity. However, there is need to conceptualise these early-life factors, how they relate each other, provide conceptual framing for future research on aetiology modelling prevention scenarios We develop framework characterise population-level domains determinants
Most people living with multiple long-term condition multimorbidity (MLTC-M) are under 65 (defined as 'early onset'). Earlier and greater accrual of conditions (LTCs) may be influenced by the timing nature exposure to key risk factors, wider determinants or other LTCs at different life stages. We have established a research collaboration titled 'MELD-B' understand how determinants, sentinel (the first LTC in lifecourse) sequence affect early-onset, burdensome MLTC-M, inform prevention...
Abstract Many studies use a reductionist approach to isolate the influence of one factor in childhood on multimorbidity rather than consider combined effect wider determinants. We explored how potential multiple early-life determinants can be characterised across three UK cohort studies. used National Child Development Study (NCDS), 1970 British Cohort (BCS70), and Aberdeen Children 1950s (ACONF) identified variables that fit into 12 domains multimorbidity. Variables were assigned domains;...
Abstract Background Obesity and hypertension are major public health problems associated with adverse outcomes. To model realistic prevention scenarios inform policy, it may be helpful to conceptualise early lifecourse domains of risk incorporate such information when predicting comorbidity We identify exposures across five pre-hypothesised childhood explore them as predictors obesity in adulthood. Methods The analytical sample included 7858 participants the 1970 British Cohort Study....
<title>Abstract</title> Background Multiple long-term conditions (MLTCs), living with two or more (LTCs), often termed multimorbidity, has a high and increasing prevalence globally earlier age of onset in people deprived communities. A holistic understanding the patient’s perspective work associated MLTCs is needed. This study aimed to synthesise qualitative evidence describing experiences develop greater effect on people’s lives. Methods Three concepts (multimorbidity, burden lived...
Abstract Background Multiple long-term conditions (MLTCs), living with two or more (LTCs), often termed multimorbidity, has a high and increasing prevalence globally earlier age of onset in people deprived communities. A holistic understanding the patient’s perspective work associated MLTCs is needed. This study aimed to synthesise qualitative evidence describing experiences (multimorbidity) develop greater effect on people’s lives ways which 'burdensome' for people. Methods Three concepts...
ObjectivePersonalised care requires the identification of modifiable risk factors so that interventions can be implemented rapidly following a gynaecological cancer diagnosis. Our objective was to determine what pre-treatment are associated with quality life (QOL) at baseline (pre-treatment) and 12 months.Methods1222 women confirmed diagnosis endometrial, ovarian, cervical or vulvar from 82 UK NHS hospitals agreed complete questionnaires baseline, three months. Questionnaires included...
The prevalence of multiple long-term condition (LTC) multimorbidity is increasing with younger onset among socioeconomically deprived populations. Research on life course trajectories towards limited and early-onset poorly characterised. Understanding sentinel conditions (the first LTC occurring in the course), sequence accrual permanency reporting LTCs may help identify time points for prevention efforts. We used a longitudinal birth cohort to estimate common three-condition (multiple...
Background Previous research indicated that birth order was associated with physical health outcomes in adulthood. However, evidence on its association mental lacking. The aim of this study to investigate if wellbeing and psychological distress at mid-life, stratified by gender, taking into account confounding factors childhood Method sample consisted 9,354 participants the 1970 British Cohort Study (BCS70). Warwick Edinburgh Mental Wellbeing Scale (WEMWBS), Malaise Index attending a...
Abstract Social life course determinants of adult hypertension are relatively unknown. This paper examines how parental separation before age 10 relates to at 46. Adjusting for confounders and considering the role mediators, we aim quantify unexplored mediating pathways in childhood using prospectively collected data. Data from 1970 British Birth Cohort Study utilised. Hypertension is measured by health care professionals Potential include body mass index (BMI), systolic diastolic blood...
Abstract Purpose We have established the SAIL MELD-B electronic cohort (e-cohort SMC) and children Young adults e-cohort (SMYC) as a part of Multidisciplinary Ecosystem to study Lifecourse Determinants Prevention Early-onset Burdensome Multimorbidity (MELD-B) project. Each has been created investigate develop deeper understanding lived experience ‘burdensomeness’ multimorbidity by identifying new clusters burdensomeness indicators, exploring early life risk factors modelling hypothetical...
Abstract Recent demographic changes in Western countries have resulted higher rates of partnership dissolution and serial partnering, an increase childbearing across multiple partnerships. This has given rise to more complex family dynamics including multi-partner fertility (MPF), defined as having biological children with two or partners. Yet estimates MPF the UK not previously been available. paper describes ‘indirect approach’ estimate prevalence UK, for men women, different assumptions....
ObjectivesMany studies use a reductionist approach to isolate the influence of one factor in childhood on multimorbidity rather than consider combined effect wider determinants. We aimed explore how potential multiple early-life determinants can be audited and characterised across three UK cohort studies. ApproachWe used 1958 National Child Development Study (NCDS), 1970 British Cohort (BCS70), Aberdeen Children 1950s (ACONF) identify categorise variables that fit into 12 previously...
ObjectivesThrough the Multidisciplinary Ecosystem to study Lifecourse Determinants and Prevention of Early-onset Burdensome Multimorbidity (MELD-B) project, we established SAIL MELD-B e-cohort (SMC) Young adults (SMYC), with aim enhance understanding ‘burdensomeness’ in individuals living multimorbidity, including identifying new clusters burdensome indicators, exploring early life risk factors modelling potential preventative scenarios. ApproachWe use routinely-collected anonymised linked...
Abstract Background Interactions with secondary care, including multiple outpatient appointments and hospital admissions, represents a common often burdensome aspect of healthcare utilisation for people living long-term conditions. Lifecourse factors such as education academic ability may play role in shaping the risk later adulthood. We explored association between childhood both admissions adulthood, accounting mediating adult factors, Method The analytical sample consisted 7183...
Abstract Background For outcomes such as obesity and hypertension, determinants are likely to be complex multidimensional. Therefore, design realistic interventions, epidemiological research should incorporate information from multiple risk exposure domains assess the effect on health. In this paper we explore scores for five early life odds of hypertension comorbidity. Methods We used data 17,196 participants in 1970 British Cohort Study. The outcome was (BMI ≥ 30) (blood...
Abstract Background Early life exposures can increase the risk of both obesity and hypertension in adulthood. In this paper we identify across five pre-hypothesised childhood domains, explore them as predictors comorbidity using 1958 National Child Development Study (NCDS), discuss these results comparison to a similar approach another birth cohort (the 1970 British Cohort (BCS70)). Methods The analytical sample included 9150 participants. outcome was (BMI ≥30) (blood pressure>140/90mm...
Whilst research has demonstrated an intergenerational transmission of partnership dissolution, there is limited evidence as to the early life course pathways through which these associations operate, and whether differ by gender. Many studies have not considered prospective data from childhood, thus potentially neglecting importance childhood period in explaining this transmission. Given that serial partnering become increasingly commonplace it important considers those who experience...