A5080993028- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- RNA and protein synthesis mechanisms
- Liver Disease Diagnosis and Treatment
- Chemical Synthesis and Analysis
- Pharmacogenetics and Drug Metabolism
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Monoclonal and Polyclonal Antibodies Research
- Drug Transport and Resistance Mechanisms
Duke University
2021-2025
Pfizer (United States)
2020
Texas A&M Health Science Center
2018
University of Connecticut
2018
University of Puerto Rico System
2018
G protein–coupled receptors (GPCRs) modulate various physiological functions by rewiring cellular gene expression in response to extracellular signals. Control of GPCRs has been studied almost exclusively at the transcriptional level, neglecting an extensive amount regulation that takes place translationally. Hence, little is known about nature and mechanisms gene-specific posttranscriptional downstream receptor activation. Here, we apply unbiased multiomics approach delineate translational...
Cannabinoid receptor 1 (CB<sub>1</sub>) is a G-protein–coupled that abundant in the central nervous system. It binds several compounds its orthosteric site, including endocannabinoids, arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol, plant-derived Δ<sup>9</sup>-tetrahydrocannabinol, one of main psychoactive components marijuana. primarily couples to G<sub>i/o</sub> proteins inhibit adenylate cyclase activity typically induces downstream signaling G<sub>i</sub>-dependent....
ABSTRACT G protein-coupled receptors (GPCRs) modulate various physiological functions by re-wiring cellular gene expression in response to extracellular signals. Control of GPCRs has been studied almost exclusively at the transcriptional level, neglecting an extensive amount regulation that takes place translationally. Hence, little is known about nature and mechanisms gene-specific post-transcriptional downstream receptor activation. Here, we apply unbiased multiomics approach delineate...
<b>Abstract ID 16887</b> <b>Poster Board 150</b> Ligand activation of G protein-coupled receptors (GPCRs) induces a plethora cellular responses that ultimately culminate in changes protein expression. Our lab and others have demonstrated certain GPCR-dependent feed into expression are biased by receptor localization. Specifically, we shown gene transcription is stimulated downstream endosomal receptors. However, represents only one layer regulation, therefore analysis steady-state RNA...
Upon activation by extracellular stimuli, G protein-coupled receptors (GPCRs) activate complex intracellular signaling networks to invoke diverse cellular responses that ultimately culminate in changes protein expression levels. Historically, standard practice for global evaluation of the downstream consequences GPCR relies on measuring RNA rather than expression. However, we know transcription is not end-game cells, and there substantial evidence a broad array contexts indicating these two...