A5075237409- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Total Knee Arthroplasty Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Knee injuries and reconstruction techniques
- Dental materials and restorations
- Robotic Mechanisms and Dynamics
- Orthopedic Surgery and Rehabilitation
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- Corporate Finance and Governance
- Circular RNAs in diseases
- Bone fractures and treatments
- Auditing, Earnings Management, Governance
- Tendon Structure and Treatment
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Ultrasound and Hyperthermia Applications
- Cancer-related molecular mechanisms research
Sichuan University
2016-2025
Guangzhou Medical University
2025
Qingzhou City People's Hospital
2025
State Key Laboratory of Oral Diseases
2013-2024
Shantou University
2023-2024
Stomatology Hospital
2008-2024
West China Hospital of Sichuan University
2023-2024
Chung Yuan Christian University
2016-2024
The First Affiliated Hospital, Sun Yat-sen University
2019-2022
Sun Yat-sen University
2019-2022
Tissue engineering provides an important approach for bone regeneration. Calcium phosphate cement (CPC) can be injected to fill complex-shaped defects with excellent osteoconductivity. Induced pluripotent stem cells (iPSCs) are exciting regenerative medicine due their potential proliferate and differentiate into of all three germ layers. To date, there has been no report on iPSC seeding CPC scaffolds. The objectives this study were (1) obtain iPSC-derived mesenchymal (iPSC-MSCs); (2) seed...
Surgical reconstruction is generally recommended for posterior cruciate ligament (PCL) injuries; however, the use of grafts still a controversial problem. In this study, three-dimensional finite element model human tibiofemoral joint with articular cartilage layers, menisci, and four main ligaments was constructed to investigate effects graft strengths on knee kinematics in-situ forces PCL grafts. Nine different stiffness ranging from 0% (PCL rupture) 200%, in increments 25%, an intact PCL's...
Platelet-rich fibrin (PRF) is an autologous growth factor carrier that promotes bone tissue regeneration, but its effectiveness restrained by poor storage capabilities, uncontrollable concentration of factors, unstable shape, etc. Herein, we developed a photocrosslinkable composite hydrogel incorporating lyophilized PRF exudate (LPRFe) into the carboxymethyl chitosan methacryloyl (CMCSMA)/gelatin (GelMA) to effectively solve dilemma PRF. The possessed suitable physical properties and...
Abstract Despite the significance of chiral allene skeletons in catalysis, organic synthesis and medicinal chemistry et al., there is a scarcity reports on axially allenyl phosphorus compounds. Here, we disclosed an efficient straightforward cascade reaction between ethynyl ketones phosphine oxides, resulting broad array trisubstituted allenes incorporating moiety high yields with excellent stereoselectivities facilitated by peptide‐mimic phosphonium salt (PPS) Additionally, comprehensive...
Angiogenesis is a limiting factor in regenerating large bone defects. The objective of this study was to investigate angiogenic and osteogenic effects co-culture on calcium phosphate cement (CPC) scaffold using human umbilical vein endothelial cells (hUVECs) mesenchymal stem (MSCs) from different origins for the first time. hUVECs were co-cultured with four types cell: cord MSCs (hUCMSCs), marrow (hBMSCs) induced pluripotent (hiPSC-MSCs) embryonic (hESC-MSCs). Constructs implanted 8 mm...
A major challenge in repairing large bone defects with tissue-engineered constructs is the poor vascularization defect. The lack of vascular networks leads to insufficient oxygen and nutrients supply, which compromises survival seeded cells. To achieve favorable regenerative effects, prevascularization by co-culturing endothelial cells a promising strategy. aim this study was investigate effects human-induced pluripotent stem cell-derived mesenchymal (hiPSC-MSCs) co-cultured human umbilical...
Abstract Objectives The hypoxia-inducible factor 1-α (HIF1α), a key molecule in mediating bone-vessel crosstalk, has been considered promising target for treating osteoporosis caused by gonadal hormones. However, senile osteoporosis, with accumulated senescent cells aged bone, distinct pathogenesis. study aimed at revealing the unknown role of HIF1α thus broadening its practical application osteoporosis. Materials and methods Femurs tibias were collected from untreated mice various ages (2...
Tissue engineering approaches are promising to meet the increasing need for bone regeneration. Calcium phosphate cement (CPC) can be injected and self-set form a scaffold with excellent osteoconductivity. The objectives of this study were develop macroporous CPC-chitosan-fiber construct containing alginate-fibrin microbeads encapsulating human umbilical cord mesenchymal stem cells (hUCMSCs) investigate hUCMSC release from degrading proliferation inside porous CPC construct....
Calcium phosphate cement (CPC) has in situ-setting ability and excellent osteoconductivity. Human embryonic stem cells (hESCs) are exciting for regenerative medicine due to their strong proliferative multilineage differentiation capability. However, there been no report on hESC seeding with CPC. The objectives of this study were obtain hESC-derived mesenchymal (hESCd-MSCs), investigate hESCd-MSC proliferation osteogenic novel CPC chitosan immobilized RGD (CPC-chitosan-RGD). was covalently...