A5086254960- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- MicroRNA in disease regulation
- Luminescence and Fluorescent Materials
- Oral microbiology and periodontitis research
- Mesenchymal stem cell research
- Endodontics and Root Canal Treatments
- Cancer, Hypoxia, and Metabolism
- Graphene and Nanomaterials Applications
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Telomeres, Telomerase, and Senescence
- Dental Health and Care Utilization
- Bone and Dental Protein Studies
- Underwater Vehicles and Communication Systems
- Fluid Dynamics Simulations and Interactions
- Dynamics and Control of Mechanical Systems
- Circular RNAs in diseases
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Probiotics and Fermented Foods
- Photodynamic Therapy Research Studies
- Laser Applications in Dentistry and Medicine
State Key Laboratory of Oral Diseases
2022-2024
Sichuan University
2022-2024
Stomatology Hospital
2022
Platelet-rich fibrin (PRF) is an autologous growth factor carrier that promotes bone tissue regeneration, but its effectiveness restrained by poor storage capabilities, uncontrollable concentration of factors, unstable shape, etc. Herein, we developed a photocrosslinkable composite hydrogel incorporating lyophilized PRF exudate (LPRFe) into the carboxymethyl chitosan methacryloyl (CMCSMA)/gelatin (GelMA) to effectively solve dilemma PRF. The possessed suitable physical properties and...
Abstract Objectives The hypoxia-inducible factor 1-α (HIF1α), a key molecule in mediating bone-vessel crosstalk, has been considered promising target for treating osteoporosis caused by gonadal hormones. However, senile osteoporosis, with accumulated senescent cells aged bone, distinct pathogenesis. study aimed at revealing the unknown role of HIF1α thus broadening its practical application osteoporosis. Materials and methods Femurs tibias were collected from untreated mice various ages (2...
Non-thermal atmospheric plasma (NTAP) modification to induce a hydrophilic titanium (Ti) surface with less carbon contamination, has been demonstrated boost the osteogenic responses. In this study, we investigated underlying bone formation mechanism of NTAP-Ti, and involvement PI3K/Akt signaling pathway in regulating activities on NTAP-Ti surfaces. NTAP was employed for Ti activation, PI3K inhibitor, LY294002, applied suppression pathway. We systematically quantitatively detected cell...
Using the GelMA hydrogel as a carrier and adenovirus-mediated transfection of overexpressing circRNAs (hsa-circ-0003376, named circ-CTTN), osteogenic efficiency human umbilical cord mesenchymal stem cells (hUCMSCs) can be significantly enhanced.
Osteoporosis is a metabolic disease characterized by bone density and trabecular loss. Bone loss may affect dental implant osseointegration in patients with osteoporosis. To promote osteoporotic patients, we further used nonthermal atmospheric plasma (NTAP) treatment device previously developed our research group. After the titanium (Ti) placed into device, working gas flow electrode switches are turned on, completed 30 s. Previous studies showed that this NTAP can remove carbon...
Human umbilical cord mesenchymal stem cells (hUCMSCs) are attractive therapeutic for tissue engineering to treat bone defects. However, how the can differentiate into remains unclear. Long non-coding RNAs (lncRNAs) that participate in many biological processes, including cell differentiation. In this study, we investigated profiles and functions of lncRNAs osteogenic differentiation hUCMSCs. We identified 343 differentially expressed during differentiation, which 115 were upregulated 228...
Background: Hydrophilic dental implants are gaining increasing interest for their ability to accelerate bone formation. However, commercially available hydrophilic implants, such as SLActive™, have some major limitations due time-dependent biological aging and lower cost-effectiveness. The non-thermal atmospheric plasma (NTAP) treatment is a reliable way gain surface enhance osseointegration. few studies been carried out compare the osseointegration of NTAP-functionalized titanium implants....
The integrin-mediated immunomodulatory effects of hydrophilic titanium modified by non-thermal atmospheric plasma (NTAP), and improved osteogenic responses under this NTAP-created immune microenvironment.