A5053239136- Suicide and Self-Harm Studies
- Mental Health Treatment and Access
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Fungal and yeast genetics research
- Homicide, Infanticide, and Child Abuse
- Health and Wellbeing Research
- Psychosomatic Disorders and Their Treatments
- Biofuel production and bioconversion
- Genetic Associations and Epidemiology
- Neurobiology and Insect Physiology Research
- Ion Channels and Receptors
- Child and Adolescent Psychosocial and Emotional Development
- Hormonal Regulation and Hypertension
- Tryptophan and brain disorders
- Ion channel regulation and function
- Cardiac Health and Mental Health
- Opioid Use Disorder Treatment
- Emotion and Mood Recognition
- Traumatic Brain Injury Research
- Mental Health via Writing
- Advanced Cellulose Research Studies
- Reproductive Health and Technologies
- Child Abuse and Trauma
- Reproductive Health and Contraception
Seoul National University
2004-2025
Seoul National University Hospital
2019-2024
New Generation University College
2009-2023
Weatherford College
2022
Maria Fertility Hospital
2018
Federation of Busan Science and Technology
2016
Both minor and major depression have high prevalence are important causes of social burden worldwide; however, there is still no objective indicator to detect depression. This study aimed examine if voice could be used as a biomarker Ninety-three subjects were classified into three groups: the not depressed group (n = 33), depressive episode 26), 34), based on current status dimension. Twenty-one features extracted from semi-structured interview recordings. A three-group comparison was...
Abstract Background The incidence and burden of depressive disorders are increasing in South Korea. There many differences between pharmaceutically treated depression (PTD) treatment-resistant (TRD), including the economic consequences; however, to our knowledge, is understudied Therefore, objective present study was calculate different costs PTD TRD Korea, specifically by comparing several aspects medical care. Methods This comprised patients aged 18 over who were newly prescribed...
Depression and suicide are critical social problems worldwide, but tools to objectively diagnose them lacking. Therefore, this study aimed depression through machine learning determine whether it is possible identify groups at high risk of words spoken by the participants in a semi-structured interview.A total 83 healthy depressed patients were recruited. All recorded during Mini-International Neuropsychiatric Interview. Through assessment from interview items, with classified into...
Abstract Although depression is an emerging disorder affecting many people worldwide, most genetic studies have been performed in European descent populations. Herein, a genome-wide association study (GWAS) was conducted Korean population to elucidate the genomic loci associated with depressive symptoms. Two independent cohorts were used as discovery datasets, which consisted of 6474 (1484 cases and 4990 controls) 1654 (557 1097 participants, respectively. The participants divided into case...
Despite previous efforts to build statistical models for predicting the risk of suicidal behavior using machine-learning analysis, a high-accuracy model can lead overfitting. Furthermore, internal validation cannot completely address this problem. In study, we created occurrence suicide attempts among Koreans at high suicide, and verified these in an independent cohort. We performed logistic penalized regression within 6 months ideators attempters The Korean Cohort Model Predicting Suicide...
Assessing a patient's suicide risk is challenging for health professionals because it depends on voluntary disclosure by the patient and often has limited resources. The application of novel machine learning approaches to determine clinical utility.This study aimed investigate cross-sectional longitudinal assess suicidality based acoustic voice features psychiatric patients using artificial intelligence.We collected 348 recordings during interviews 104 diagnosed with mood disorders at...
Suicide is a complex phenomenon; therefore, it should be approached in light of sociocultural perspectives and the general attitude toward suicide. This study aimed to extract factors from Attitude Toward Scale (ATTS) investigate relationship between attitudes suicide suicidal behavior (i.e., idea, plan, attempt) by using representative sample Korean adults.Three thousand Koreans aged 19 75 years were surveyed cross-sectionally 2013 2018. The data collected subjected exploratory factor...
This study aimed to identify underlying demographic and clinical characteristics among individuals who had previously attempted suicide, utilizing the comprehensive Health Insurance Review Assessment Service (HIRA) database. Data of patients aged 18 above suicide between January 1 December 31, 2014, recorded in HIRA, were extracted. The index date was identified when a attempt made within year 2014. medical history three years before seven follow-up data after analyzed. Kaplan-Meier estimate...
Plant and fruit extracts exhibit fewer side effects than pharmaceuticals can display therapeutic qualities. Consequently, they have attracted increased attention among health-conscious individuals, many studies related to their health-promoting are being actively conducted. Vitis coignetiae is well-known for its antioxidant, anti-inflammatory, anticancer properties. However, the immune-enhancing of not yet been studied. In this study, extract (VCE) immune-related activity in Wistar rat...
Despite a plethora of research on the topic, there is still no solid evidence that pharmacological treatment actually reduces risk suicide in patients with mental illness. In this study, we aimed to assess effect psychotropic medications suicidal ideation major depressive disorder (MDD) and bipolar (BPD) two age groups: less than 25 years older. We analyzed 312 mood disorders current thoughts or recent attempts. followed participants from baseline for 6 months assessed changes...
Background Attitudes toward suicide are essential in prevention, as is socio-culturally nuanced. Although the relationship between individual attitudes and suicidal behavior has been extensively studied, effect of community attitudes—aggregated by region—on mortality remains ambiguous. This study explored association real-world mortality. Methods Data on from 2018 Korea National Suicide Survey (N = 1500) data MicroData Integrated System were obtained. Confirmatory factor analysis supported a...
Suicide is a leading cause of death worldwide, presenting serious public health problem. We aimed to investigate the biological basis suicide completion using proteomics on postmortem brain tissue. Thirty-six samples (23 completers and 13 controls) were collected. evaluated proteomic profile in prefrontal cortex (Broadmann area 9, 10) tandem mass tag-based quantification with liquid chromatography-tandem spectrometry. Bioinformatics tools used elucidate mechanisms related suicide. Subgroup...
For the prolonged, controlled delivery of systemic drugs, we propose an implantable drug-delivery chip (DDC) embedded with pairs a microchannel and drug-reservoir serving as drug diffusion barrier depot, respectively. We pursued DDC for dual drugs: main-purpose drug, diclofenac (DF), exposure, antifibrotic tranilast (TR), local delivery. Thus, problematic fibrotic tissue formation around implanted device could be diminished, thereby less hindrance in exposure DF released from DDC. First,...
The classical type of transient receptor potential (TRPC) channel is a molecular candidate for Ca(2+)-permeable cation channels in mammalian cells. Because TRPC4 and TRPC5 belong to the same subfamily TRPC, they have been assumed physiological properties. However, we found that had its own functional characteristics different from those TRPC5. no constitutive activity were activated by muscarinic stimulation only when was co-expressed with human embryonic kidney (HEK) Endogenous appeared not...
uvi31+ is a sequence homolog of Escherichia coli bolA gene in Schizosaccharomyces pombe, identified as UV-inducible gene. Here, the cellular function was investigated by null mutant analysis. Deletion led to delayed germination spore and defects subsequent cell division. However, uvi31 proliferated faster with smaller size than wild-type during vegetative growth. In addition, sensitive UV-light. It showed normal cycle delay after UV-irradiation but displayed aberrant septum formation...