A5028977824- Virology and Viral Diseases
- Amyotrophic Lateral Sclerosis Research
- Viral Infections and Vectors
- Cholinesterase and Neurodegenerative Diseases
- Animal Virus Infections Studies
- Autophagy in Disease and Therapy
- Melanoma and MAPK Pathways
- Research on Leishmaniasis Studies
- Neurogenetic and Muscular Disorders Research
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Alzheimer's disease research and treatments
- Animal Disease Management and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Calcium signaling and nucleotide metabolism
- SARS-CoV-2 and COVID-19 Research
- Microbial infections and disease research
- Cancer Mechanisms and Therapy
- Vector-Borne Animal Diseases
Max Planck Institute for Biology of Ageing
2022-2024
Jilin University
2015-2018
Suppression of target rapamycin complex 1 (TORC1) by ameliorates aging in diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are unclear. Here we show that activation S6K specifically Drosophila fat-body blocked extension lifespan rapamycin, induced accumulation multilamellar lysosomes and age-associated hyperactivation NF-κB-like immune deficiency (IMD) pathway, indicative reduced inflammaging. Syntaxin 13 mediated effects TORC1-S6K signaling on lysosome...
Newcastle disease (ND), caused by infections with virulent strains of virus (NDV), is one the most important infectious affecting wild, peridomestic, and domestic birds worldwide. Vaccines constructed from live, low-virulence (lentogenic) viruses are accepted prevention control strategies for combating ND in poultry across globe. Avian macrophages first cell lines defense against microbial infection, responding to signals microenvironment. Although considered be main target cells NDV...
Avian paramyxovirus serotype 4 (APMV-4) is found sporadically in wild birds worldwide, and it an economically important poultry pathogen. Despite the existence of several published strains, very little known about distribution, host species, transmission APMV-4 strains. To better understand relationships among these factors, we conducted surveillance domestic six provinces China suspected being intercontinental flyways sites interspecies transmission. was 9,160 representing seven 1,461 live...
Newcastle disease (ND), caused by the virulent virus (NDV), is one of most important viral diseases birds globally, but little currently known regarding enzootic trends NDV in northeastern China, especially for class I viruses. Thus, we performed a surveillance study China from 2013 to 2015. A total 755 samples wild and domestic wetlands live bird markets (LBMs) were collected, 10 isolates identified. Genetic phylogenetic analyses showed that five LBMs belong subgenotype 1b, two (one LBMs)...
Hexanucleotide repeat expansions in the C9orf72 gene are most prevalent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Transcripts translated into toxic dipeptide (DPR) proteins. Most preclinical studies cell animal models have used protein-tagged polyDPR constructs to investigate DPR toxicity but effects tags on not been systematically explored. Here, we Drosophila assess influence protein toxicity. Tagging 36 100 arginine-rich DPRs with mCherry increased...
Abstract G 4 C 2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are most common cause familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). insertion length is variable, patients can carry up to several thousand repeats. Dipeptide proteins (DPRs) translated from transcripts thought be main driver toxicity. Experiments model organisms with relatively short DPRs have shown that arginine-rich toxic, while polyGlycine–Alanine (GA) only mild...
Newcastle disease virus (NDV) causes a severe and economically significant affecting almost the entire poultry industry worldwide. However, factors that affect NDV replication in host cells are poorly understood. Raf kinase inhibitory protein (RKIP) is physiological inhibitor of c-RAF NF-κB signalling, known for their functions control immune response as well tumour invasion metastasis. In present study, we investigated consequences overexpression RKIP during viral infection. We demonstrate...
Abstract The nutrient-sensing Target of Rapamycin complex 1 (TORC1) is an evolutionarily conserved regulator longevity and healthspan. S6 kinase (S6K) essential downstream mediator for the effect TORC1 on longevity. However, mechanistic insights how TORC1-S6K signalling promotes lifespan healthspan are still limited. Here we show that activity S6K in Drosophila fat body rapamycin-mediated Fat-body-specific activation blocked extension upon rapamycin feeding induced accumulation multilamellar...