A5042997434- Parasites and Host Interactions
- Helminth infection and control
- Clostridium difficile and Clostridium perfringens research
- Parasite Biology and Host Interactions
- Gut microbiota and health
- Bacterial Identification and Susceptibility Testing
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Insect Utilization and Effects
New York University
2019-2023
McGill University
2019
Parasitic helminths cause significant damage as they migrate through host tissues to complete their life cycle. While chronic helminth infections are characterized by a well-described Type 2 immune response, the early, tissue-invasive stages not well understood. Here we investigate pathways activated during early of Heligmosomoides polygyrus bakeri (Hpb), natural parasitic roundworm mice. In contrast response present at later infection, robust 1 signature including IFNg production was...
The bacterial microbiota promotes the life cycle of intestine-dwelling whipworm Trichuris by mediating hatching parasite eggs ingested mammalian host. Despite enormous disease burden associated with colonization, mechanisms underlying this transkingdom interaction have been obscure. Here, we used a multiscale microscopy approach to define structural events bacteria-mediated for murine model muris . Through combination scanning electron (SEM) and serial block face SEM (SBFSEM), visualized...
The bacterial microbiota promotes the life cycle of intestine-dwelling whipworm
Journal Article Optimization Of Scanning Electron Microscopy and Serial Block Face – for Investigating Bacteria Whipworm Egg Interactions Get access Amicha Robertson, Robertson Kimmel Center Biology Medicine at the Skirball Institute, New York University Grossman School of Medicine, York, NY, USADepartment Microbiology, USA Corresponding author: amicha.robertson@nyulangone.org Search other works by this author on: Oxford Academic Google Scholar Joseph Sall, Sall The Laboratory, Chris...
Abstract Intestinal helminths infect over two billion people worldwide and can cause significant morbidity. In many cases, however, individuals fail to develop resistance these tissue-invasive pathogens, indicating that mammalian hosts have evolved unknown strategies tolerate infection. To investigate the mechanisms underlying host tolerance helminth infection, we examined initial tissue invasive stage of Heligmosomoides polygyrus bakeri (Hpb), a natural parasitic roundworm infection mice....
Abstract Soil transmitted intestinal worms known as helminths colonize over 1.5 billion people worldwide. Although helminth colonization has been associated with altered composition of the gut microbiota, such increases in Clostridia, individual species have not isolated and characterized. Here, we sequenced genome 13 Clostridia from Orang Asli, an indigenous population Malaysia high prevalence infections. Metagenomic analysis 650 fecal samples urban rural Malaysians revealed higher...