A5003113973- Parasites and Host Interactions
- Drug Transport and Resistance Mechanisms
- Helminth infection and control
- Photodynamic Therapy Research Studies
- Power Systems Fault Detection
- Trypanosoma species research and implications
- Natural product bioactivities and synthesis
- Parasite Biology and Host Interactions
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Pharmaceutical Economics and Policy
- Genomics, phytochemicals, and oxidative stress
- Systemic Lupus Erythematosus Research
- Congenital Diaphragmatic Hernia Studies
- Research on Leishmaniasis Studies
- Trace Elements in Health
- Preterm Birth and Chorioamnionitis
- Public Health in Brazil
- Islanding Detection in Power Systems
- Reproductive Health and Contraception
- Protein Tyrosine Phosphatases
- Enzyme-mediated dye degradation
- Pregnancy and Medication Impact
- Phytochemical compounds biological activities
- Phytochemistry and Bioactivity Studies
Indiana University School of Medicine
2021-2023
Indiana University – Purdue University Indianapolis
2021-2023
Universidade Estadual de Maringá
2011-2019
Fundação Oswaldo Cruz
2011
Abstract Background Schistosomiasis remains an important parasitic disease and a major economic problem in many countries. The Schistosoma mansoni genome predicted proteome sequences were recently published providing the opportunity to identify new drug candidates. Eukaryotic protein kinases (ePKs) play central role mediating signal transduction through complex networks are considered druggable targets from medical chemical viewpoints. Our work aimed at analyzing S. order classify all ePKs...
Aims Physiologically based pharmacokinetic (PBPK) models have been previously developed for betamethasone and buprenorphine pregnant women. The goal of this work was to replicate reassess these using data from recently completed studies. Methods Betamethasone PBPK were in Simcyp V19 on prior publications V17 V15. Ability verified by comparing predictions those published. Once replication verified, reassessed observed additional studies Model performance upon visual inspection concentration...
The pharmacokinetic properties of a new molecular entity are important aspects in evaluating the viability compound as pharmacological agent. sesquiterpene lactone lychnopholide exhibits biological activities. objective this study was to characterize pharmacokinetics after intravenous administration 1.65 mg/kg (n = 5) and oral 3.3 3) rats (0.2 ± 0.02 kg weight) through nonlinear mixed effects modeling non-compartmental analysis. A highly sensitive analytical method used quantify plasma...
Trichilia catigua A. Juss., Meliaceae, known as catuaba in Brazil, is traditionally used for the treatment of stress, sexual impotence and memory deficits. To our knowledge, there no analytical method described literature simultaneous quantification extract marker substances biological matrices. The aim this study was to develop validate a bioanalytical by LC–MS/MS quantify epicatechin procyanidin B2 rat plasma after administration standardized T. catigua. Chromatographic separation achieved...
The IMPROVE study (NCT02408315) compared the efficacy and safety of vaginal buccal administration misoprostol for full-term, uncomplicated labor induction. This report compares pharmacokinetics between routes. Women greater than or equal to 14 years age undergoing induction 37 weeks gestation without significant complications were randomized 25 μg followed by 50 doses every 4 h. Misoprostol acid concentrations determined using liquid chromatography-tandem mass spectrometry first 8 h in a...
Lychnopholide is a sesquiterpene lactone usually obtained from Lychnophora and Eremanthus species has pharmacological activities that include anti-inflammatory anti-tumor. isolated matogrossenssis was analyzed in this study. The aims of study were to develop validate an analytical methodology by LC-MS/MS quantify lychnopholide rat plasma. Chromatographic separation achieved on C18 column using isocratic elution with the mobile phase consisting methanol water (containing 0.1% formic acid) at...
Abstract APX3330 ((2E)‐2‐[(4,5‐dimethoxy‐2‐methyl‐3,6‐dioxo‐1,4‐cyclohexadien‐1‐yl)methylene]‐undecanoic acid), a selective inhibitor of APE1/Ref‐1, has been investigated in treatment hepatitis, cancer, diabetic retinopathy, and macular edema. is administered orally as quinone but rapidly converted to the hydroquinone form. This study describes pharmacokinetics explores effect food on absorption. Total plasma concentrations were obtained following oral administration from studies healthy...
Abstract Background Recent evidence including GWAS and differential gene expression comparing normal to affected Alzheimer’s brain tissue have identified risk protective variants in genes such as TREM2, PLCG2 INPP5D that are essential microglia function. encodes SHIP1, a multi‐domain protein with phosphatase converts PI(3,4,5)P 3 PI(3,4)P 2 , SH2 domain interacts receptor ITAMs competes SYK, proline rich region binds many other proteins. SHIP1 therefore limits activation multiple ways....
Betamethasone (BMZ) is used to accelerate fetal lung maturation in women with threatened preterm birth, but its efficacy variable and limited by the lack of patient individualization dosing administration. To determine sources variability potential opportunities for therapy, objective this study was evaluate maternal factors associated development neonatal respiratory distress syndrome (RDS) a cohort who received betamethasone.This prospectively enrolled women, gestational ages 23-34 weeks,...
A leishmaniose tegumentar americana é considerada uma das cinco doenças infectaparasitáriasendêmicas de maior relevância. É comum que o conhecimento acerca destadoença restrinja-se às vítimas da infecção ou àquelas já tiveram casos na família,dificultando estabelecimento medidas efetivas controle. Este trabalho teve porobjetivo analisar relacionando-o com a epidemiologia porLeishmania sp, em indivíduos residentes cidade Mandaguaçu-PR. Trata-se umestudo descritivo, analítico realizado 42...
Faults during transmission line operations are prone to occur, which reinforces the need for protection instruments ensure safety of facilities involved and, in case power outages, restore energy supply least amount time as possible. In this context, two terminal impedance-based fault locators widely used real installations, since they overcome limitations single-terminal approaches. paper, a study is carried out evaluate performance four classical location methods system subjected...
In this paper, the impacts of fixed series-compensated transmission lines (TL) on classical phasor-based fault location techniques are evaluated, in order to identify typical challenges faced by such methods. To do so, several Alternative Transients Program (ATP) simulations were carried out a 500 kV/60 Hz system, which is modeled considering parameters taken from real Brazilian network. Comparative analyses performed with uncompensated TL. From obtained results, low frequencies superimposed...