Diabetes mellitus (DM) is a significant risk factor for the development of cardiovascular complications. This study was undertaken to investigate effect chronic administration ethanolic extract Eryngium carlinae on glucose, creatinine, uric acid, total cholesterol, and triglycerides levels in serum streptozotocin- (STZ-) induced diabetic rats. Triglycerides, acid increased from The treatment with E. prevented these changes. reduced triglycerides. Thus able reduce hyperlipidemia related...

In the present study, we used a by-product from Agave lechuguilla (guishe) to test its antidiabetic effect, hypolipidemic activity, and capacity mitigate oxidative stress in kidney mitochondria streptozotocin-induced diabetic rats. Orally, crude aqueous extract lyophilized guishe was administered over 5 weeks at different doses. Blood glucose body weight were monitored. Also, blood chemistry, bilirubin, alanine aminotransferase assayed. Furthermore, activity of catalase, thiobarbituric acid...

Turnera diffusa (damiana) grows wild in Baja California Sur (BCS), Mexico. It is traditionally used for its aphrodisiac effects and diabetes treatment. Two varieties (var.) have been identified: aphrodisiaca. To evaluate the of water-ethanol extracts from both varieties, measurements on blood glucose, body weight, biochemical parameters, cell counts were performed a diabetic rat model. Oxidative stress was also evaluated when var. administered. No significant reductions glucose levels, or...

Turnera diffusa Will (damiana) is used in Mexican traditional medicine for treatment of various disorders including diabetes mellitus (DM). Not with standing, there not a study that proves this effect on DM‐STZ long period. Also, are reports about the effects damiana over oxidative stress; marker damage DM, kidney mitochondria. By reason, we set main aim work evaluate antioxidant ability important medicinal plant worldwide pathology DM. To achieve purpose use STZ‐DM rats (65mg/kg body...

Hypertension is a major risk factor for cardiovascular, Reno vascular disease. Reduction of elevated blood pressure significantly reduces the cardiovascular events. Kidney synthesizes reactive oxygen species (ROS), which under pathological conditions play an important role in renal dysfunction. Evidence indicates that increased oxidative and nitrosative stress are mediators injury pathologies. Herbal medicines being used by about 80% world population primary health care including...

Diabetic nephropathy is an important microvascular complication and the major cause of end‐stage kidney disease. E. carlinae a plant used by diabetic patients to treat complications this disease, which have been attributed diuretic anti‐inflammatory properties. This study was conducted explore changes in stress oxidative antioxidant activity mitochondria rats treated with . Were realized measurements thiobarbituric acid reactive substances (TBARS), nitric oxide (NO), dismutase superoxide...

Hypertension remains, despite major advances in understanding its pathophysiology and therapeutic approach. One condition carries high morbidity mortality worldwide herbal medicine has gained ground this area of medicine. In our group we are interested some plants used Mexico as alternative therapies for their possible antihypertensive properties. Previously, tested four extracts from Justicia spicigera (hexane, chloroform, methanol aqueous) known Muicle region the results shown that...

Diabetes mellitus is a significant risk factor for the development of cardiovascular complications. This study was undertaken to investigate effect chronic administration ethanolic extract Eryngium carlinae on glucose, creatinine, uric acid, total cholesterol, and triglycerides levels in serum streptozotocin (STZ)‐ induced diabetic rats. Triglycerides, acid increased from The treatment with E. prevented these changes. reduced triglycerides. Thus, able reduce hyperlipidemia related diabetes...

Mitochondria contribute to intracellular redox status and Ca 2+ homeostasis. Intramitochondrial concentration are regulated via an electrophoretic uniporter that is driven by the transmembrane potential. Several abnormalities have been observed in metabolism of spontaneously hypertensive rats (SHR). We studied whether mitochondrial membrane potential (mΔΨ), complex IV activity, were altered brain mitochondria 1‐month 7‐month SHR. used safranine probe determinate Complex activity was...

Mitochondria are an energetic source of cells by means the formation ATP synthesis. synthesis is regulated different mechanisms and molecules as nitric oxide (NO). NO its derivatives inhibit mitochondrial respiration in a reversibly fashion binuclear O2 binding site cytochrome c oxidase. In aging hypertension associated with dysfunction. We performed experiments to investigate if activity oxidase affected presence mitochondria three organs (brain, liver, kidney) spontaneously hypertensive...

During pathological conditions, uncontrolled amounts of free radicals are produced in mitochondria. Polyunsaturated fatty acids from mitochondrial membranes lipids the main targets ROS attack. Susceptibility (FA) to peroxidation depends on number unsaturations its hydrophobic tail. Consequently, we hypothesize that increase unsaturation degree FA will augment sensitivity function oxidative inactivation due lipid stimulation, which may lead accelerated cell death. We used S. cerevisiae yeast...

In diabetes mellitus it is found diabetic encephalopathy. Chronic hyperglycemia induces an increment in glycemia oxidation when oxidized the mitochondrial respiratory chain generate superoxide and oxidative stress. Aconitase possess a particular characteristic susceptible to damage. this study was analyzed roles of mtNO, radical peroxynitrite generation under on aconitase activity. We used streptozotocin-induced rats different ages brain mitochondria were isolated. Brain NO levels 13 14...

Diabetes mellitus (DM) is a heterogeneous metabolic disorder characterized by hyperglycemia resulting from defective insulin secretion, resistance to action or both. Oxidative damage due contributes the microvascular pathology of diabetes that occurs in renal glomerulus. The long-term complications DM include diabetic nephropathy. Veelken et al. (2000) tested vasodilatation mediated nitric oxide (NO) endothelial constitutive synthase (eNOS) activity and contributed hyperfiltration injury...

Agastache mexicana (Kunth) Lint & Epling (toronjil) is a medicinal plant distributed in the Michoacan state Mexico and used traditional medicine for gastrointestinal disorders, anxiety, cardiovascular alterations efficiently as an anti‐inflammatory analgesic among others. Ethnobotanical, pharmacological phytochemical studies have been carry out, however there are currently no scientific relevance that support their therapeutic properties. Toronjil mainly volatile oils (camphene,...

Guishe from Agave lechuguilla was used to test the capacity mitigate oxidative stress in kidney mitochondria streptozotocin-induced diabetic rats. Orally, a crude aqueous extract lyophilized guishe administered over 5 weeks at different doses (150, 300 y 600 mg/kg). Blood glucose and body weight were monitored. The activity of catalase, thiobarbituric acid reactive species, mitochondrial superoxide dismutase, glutathione peroxidase determined isolated mitochondria. Our results show that...